A5101755482- Catalytic C–H Functionalization Methods
- Pharmacological Effects of Natural Compounds
- Catalytic Cross-Coupling Reactions
- Zeolite Catalysis and Synthesis
- Asymmetric Hydrogenation and Catalysis
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Cyclopropane Reaction Mechanisms
- Alkaloids: synthesis and pharmacology
- Radical Photochemical Reactions
- Mesoporous Materials and Catalysis
- Catalysis and Oxidation Reactions
- Genomics and Phylogenetic Studies
- Plant-based Medicinal Research
- Sulfur-Based Synthesis Techniques
- Catalytic Processes in Materials Science
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Phytochemistry and Biological Activities
- Metal-Organic Frameworks: Synthesis and Applications
- Lepidoptera: Biology and Taxonomy
- Organoboron and organosilicon chemistry
- Advanced Nanomaterials in Catalysis
- Food Quality and Safety Studies
Air Force Medical University
2024-2025
Xijing Hospital
2025
Nanjing University of Chinese Medicine
2024
National Medical Products Administration
2024
Tianjin Normal University
2021-2024
Qiqihar University
2007-2024
Guangdong University of Technology
2024
Ji Hua Laboratory
2024
Anhui Xinhua University
2023
Nanjing University
2022
Enantioselective three-component difunctionalization of alkenes with boron reagents represents an attractive strategy for assembling three-dimensional chiral organoboron compounds. However, regio- and enantiocontrol comprise the pivot challenges in these transformations, which predominantly require use activated conjugated alkenes. Herein, by utilizing various carbonyl directing groups, including amides, sulfinamides, ketones, esters, we succeed realizing a nickel-catalyzed...
Cardiac fibrosis plays a critical role in the progression of various forms heart disease, significantly increasing risk sudden cardiac death. However, currently, there are no therapeutic strategies available to prevent onset fibrosis. Here, biomimetic ATP-responsive nanozymes based on genetically engineered cell membranes adapted specifically recognize activated fibroblasts (CFs) for treatment By fusing anti-FAP CAR membrane zeolitic imidazole frameworks-90 (zif-90) cores loaded with...
A mild and efficient Rh(III)-catalyzed C-H activation/esterification reaction for the synthesis of isocoumarins has been developed. This procedure uses readily available benzoic acids cyclic diazo-1,3-diketones as starting materials involves domino intermolecular activation in combination with intramolecular esterification to give corresponding moderate excellent yields. process provides a facile approach construction containing various functional groups that does not require any additives.
Palladium-catalyzed activation of remote meta-C-H bonds in arenes containing tethered alcohols was achieved with high regioselectivity by using a nitrile template. Computational studies on the macrocyclic transition state regioselectivity-determining C-H steps revealed that both C-N-Ag angles and gauche comformations phenyl ether play an extremely important role meta selectivity.
Few methods have been reported for intermolecular arylamination of alkenes, which could provide direct access to important arylethylamine scaffolds. Herein, we report an syn-1,2-arylamination unactivated alkenes with arylboronic acids and O-benzoylhydroxylamine electrophiles Ni(II) catalyst. The cleavable bidentate picolinamide directing group facilitates formation stabilized 4-, 5- or 6-membered nickelacycles enables the difunctionalization diverse alkenyl amines high levels regio-, chemo-...
A hierarchical ZSM-5 zeolite with a thinner dimension morphology has been synthesized in fluoride medium, and presents superior performance MTP reaction.
Catalytic difunctionalization of alkenes has been a prominent research theme in recent years. Here, we develop removable bidentate picolinamide-assisted regioselective dicarbofunctionalization homoallylic amines with organohalides and arylboronic acids. The catalytic system, using cost-effective air-stable Ni(II) precatalyst, which could be activated by acids, provides access to the diarylation arylalkylation unactivated alkenes. This reaction is compatible α- or β-substituted terminal...
A facile and eco-friendly approach for the synthesis of mesopore-containing ZSM-5 zeolite with small crystal size was proposed by subtly making use a coke-deposited spent catalyst. When used in methanol to propylene reaction again, refabricated catalyst exhibited much higher selectivity longer catalytic lifetime.
We disclose herein an electrochemical allylation of unactivated aldehydes and ketones with allylic alcohols. Various homoallylic alcohols can be obtained by treatment aldehydes/ketones allyl in a simple undivided cell.
Context: The buds of Coreopsis tinctoria Nutt (Compositae) are used in the treatment hypertension Uyghur folk medicine China.
Obesity is a serious medical problem worldwide. As holistic therapy, traditional Chinese medicine (TCM) may have potential in obesity management. In this controlled trial, we evaluated the safety and effectiveness of Xin-Ju-Xiao-Gao-Fang (XJXGF), TCM herbal formulation, 140 obese subjects over 24-week period. The XJXGF formula mainly consists rhubarb, coptis, semen cassia, citrus aurantium. Subjects with body mass index (BMI) 28–40 kg/m 2 were recruited at 5 centers China. We assessed...
We report herein an intermolecular syn-arylalkylation and alkenylalkylation of alkenyl amines with two different organohalides (iodides bromides) using Ni(II) catalyst. The cleavable bidentate quinolinamide is utilized after extensive directing group screening to enable olefin difunctionalization high levels regio-, chemo-, diastereocontrol. This general practical protocol compatible α- or β-substituted terminal alkenes internal alkenes, providing rapid access branched aliphatic bearing...
Angelica dahurica(BZ) and dahurica var. formosana(HBZ) are two plant sources of Angelicae dahuricae Radix. Although BZ HBZ commonly used herbal medicines with great medicinal dietary values, study on their phytochemicals bioactive compositions is limited.To compare the chemical find makers for discrimination quality evaluation botanical origins Radix.A high-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry method was established profiling HBZ. Then, a...
We report herein a three-component 1,2-arylboration of alkenyl amines bearing cleavable picolinamide directing group. With aryl halides as electrophiles and B2Pin2 nucleophiles, wide range alkenes could be converted into valuable boryl-functionalized aliphatic amines. The reaction proceeds with high levels chemo- regiocontrol exhibits functional group tolerance. In addition, the pinacol boronic ester undergo various transformations, indicating that protocol potentially provide platform for...
A removable bidentate picolinamide assisted regioselective 1,2-carbosulfenylation of unactivated alkenes with aryl/alkenylboronic acids and disulfide electrophiles has been developed a cost-effective air-stable Ni( ii ) precatalyst.
Memory loss and aberrant neuronal network activity are part of the earliest hallmarks Alzheimer’s disease (AD). Electroacupuncture (EA) has been recognized as a cognitive stimulation for its effects on memory disorder, but whether different brain regions or neural circuits contribute to recovery in AD remains unknown. Here, we found that deficit was ameliorated 3×Tg-AD mice with EA-treatment, shown by increased number exploring time spent novel object. In addition, reduced locomotor observed...
A NiH-catalyzed migratory and non-migratory multisite-selective gem -difluoroallylation of alkenyl amines with trifluoromethyl alkenes has been developed by judicious choice directing groups high levels chemo- regioselectivity.