A5101875483- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Protease and Inhibitor Mechanisms
- S100 Proteins and Annexins
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Magnetic confinement fusion research
- Hippo pathway signaling and YAP/TAZ
- interferon and immune responses
- Solar and Space Plasma Dynamics
- Cancer Genomics and Diagnostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Geophysics and Gravity Measurements
- Nanopore and Nanochannel Transport Studies
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
Tongji University
2013-2021
Tongji Hospital
2021
Anhui Medical University
2017-2020
Shanghai Jiao Tong University
2015-2019
First Hospital of Jilin University
2017-2019
Jilin University
2017-2019
Tianjin Medical University Cancer Institute and Hospital
2018
Anhui Provincial Hospital
2017
AstraZeneca (United Kingdom)
2014
Shanghai Innovative Research Center of Traditional Chinese Medicine
2013-2014
Tumor relapse after radiotherapy is a significant challenge to oncologists, even recent the advances in technologies. Here, we showed that cancer-associated fibroblasts (CAFs), major component of cancer stromal cells, promoted irradiated cell recovery and tumor radiotherapy. We provided evidence CAFs-produced IGF1/2, CXCL12 β-hydroxybutyrate were capable inducing autophagy cells post-radiation promoting from radiation-induced damage vitro vivo mice. These CAF-derived molecules increased...
Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump reduce the intracellular concentration drug(s). Thus, inhibiting P-gp expression might assist overcoming MDR chemotherapy. MiRNAome profiling using next-generation sequencing identified differentially expressed microRNAs (miRs) between parental K562 cells (K562/ADM) induced adriamycin...
Activation of the PI3K/AKT pathway is a common phenomenon in cancer due to multiple mechanisms, including mutation PI3KCA, loss or PTEN, over-expression receptor tyrosine kinases. We recently developed novel AKT kinase inhibitor, AZD5363, and demonstrated that HGC27, cell line harboring both PI3KCA PTEN loss, displayed greatest sensitivity this inhibitor vitro vivo.To further elucidate correlation between AZD5363 response genetic alterations gastric (GC) identify GC patients with mutations...
This study aimed to explore the regulatory mechanism of hsa-miR-143-3p and lncRNA RP11-363N22.3-functioning upstream KRAS-in exosomes derived from human mesenchymal stem cells (hMSCs) in pancreatic cancer.Western blotting quantitative PCR were used determine gene expression. In vitro, cell proliferation, apoptosis, cycle invasion evaluated using CCK-8 assay, flow cytometry, transwell assays, respectively. vivo, effect hsa-miR143-3p was investigated a tumorigenesis test nude mice. The...
The development of metastases involves the dissociation cells from primary tumor, penetrating basement membrane, invasion and exiting vasculature to seed, finally colonizing in distant tissues. formation brain metastasis (BM) lung adenocarcinoma remains poorly understood. We examined differential microRNA (miRNA) expression profiles 5 3 metastatic samples by Agilent miRNA Microarrays. Five upregulated miRNAs (miRs-9*, -1471, 718, 3656, 720) downregulated (miRs-214, -145 -23a) were detected....
Traf2- and Nck-interacting kinase (TNIK) is one of the germinal center family members involved in cytoskeleton organization neuronal dendrite extension. Emerging evidence supports that TNIK essential for activation WNT signaling pathway colon cancer growth. To search novel genetic aberrations drive carcinogenesis, we performed microarray-based comparative hybridization assay gene copy number variations primary tumor samples. Our data showed was amplified 7% (8/106) Chinese gastric patients....
Purpose The prognosis for colorectal cancer (CRC) patients is drastically impacted by the presence of lymph node or liver metastases at diagnosis resection. On this basis it sought to identify novel proteins as biomarkers and determinants CRC metastasis. Experimental Design Proteomic analyses are undertaken using primary tissues from ten Chinese presenting with without immunohistochemistry used validate selected in an independent patient cohort. Results Comparing against paired normal...
COPS3 encodes the third subunit of COP9 signalosome and its aberrant expression is associated with many RITE ("Region Increased Tumor Expression") genes in lung cancer tissues.To elucidate specific role cancer, we examined tissues by immunohistochemical staining.We found that was overexpressed most samples examined, particularly small cell carcinoma squamous carcinoma.The protein positively correlated level Ki-67 proliferation index (p=0.001)and negatively related to degree tumor...
Liver metastasis is the most common form of metastatic colorectal cancers during course disease. The global change in protein abundance liver and its role establishment have not been comprehensively analyzed. In present study, fresh-frozen tissue samples including normal colon/localized/liver CRCs from each recruited patient were analyzed by quantitative proteomics using a multiplexed TMT labeling strategy. Around 5000 groups quantified all samples. proteomic profile localized/metastatic...
The aim of this study was to identify an improved delivery scheme for intracellular and anticancer therapy. Novel gold nanorods (GNRs) bioconjugates were prepared by using GNRs as nonviral vectors conjugated with thiol-modified antisense oligodeoxynucleotides (ASODNs). We then investigated the possibility carriers nucleus ASODNs genes confocal microscopy cell transmission electron microscope imaging. Our results demonstrate that GNRs-ASODNs entered into increased apoptosis. Therefore, could...