A5044535814- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Advanced Fluorescence Microscopy Techniques
- Wound Healing and Treatments
- interferon and immune responses
- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Muscle Physiology and Disorders
- Aortic Disease and Treatment Approaches
- Image Processing Techniques and Applications
- Adipose Tissue and Metabolism
- Cancer-related Molecular Pathways
- Dermatological diseases and infestations
- Infective Endocarditis Diagnosis and Management
- Parasitic Infections and Diagnostics
- Insects and Parasite Interactions
- Parasites and Host Interactions
- Dermatologic Treatments and Research
- Cellular transport and secretion
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Lipid metabolism and biosynthesis
- Cellular Mechanics and Interactions
The Ohio State University Wexner Medical Center
2017-2022
The Ohio State University
2014-2021
Lung Institute
2014-2019
Auburn University
2013-2014
MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show present in blood circulation acts as myokine to facilitate tissue injury-repair and regeneration. Transgenic mice with sustained elevation of bloodstream (tPA-MG53) have healthier longer life-span when compared littermate wild type mice. The tPA-MG53 normal glucose handling insulin signaling skeletal muscle, does not deleterious impact on db/db More importantly, display...
Abstract TRIM family proteins play integral roles in the innate immune response to virus infection. MG53 (TRIM72) is essential for cell membrane repair and believed be a muscle-specific protein. Here we show human macrophages express MG53, protein expression reduced following Knockdown of leads increases type I interferon (IFN) upon knockout mice infected with influenza comparable titres wild mice, but display increased morbidity accompanied by more accumulation CD45+ cells elevation IFNβ...
Ischemic injury to the heart induces mitochondrial dysfunction due increasing oxidative stress. MG53, also known as TRIM72, is highly expressed in striated muscle, secreted a myokine after exercise, and essential for repairing damaged plasma membrane of many tissues by interacting with lipid phosphatidylserine (PS). We hypothesized MG53 could preserve integrity an ischemic event binding mitochondrial-specific lipid, cardiolipin (CL), mitochondria protection prevent mitophagy. Fluorescent...
A controlled, blind study was conducted to define the initial inflammatory response and lung damage associated with death of precardiac stages Dirofilaria immitis in cats as compared adult heartworm infections normal cats. Three groups six each were used: UU: uninfected untreated controls; PreS I: infected 100 D. L3 by subcutaneous injection treated topically selamectin 32 2 days pre-infection once monthly for 8 months); IU: left untreated. Peripheral blood, serum, bronchial lavage, thoracic...
This study presents clinical findings after oral ingestion of Toxocara cati eggs which resulted in rapid pulmonary lung migration and parenchymal disease, noted on clinically relevant diagnostic methods. Further, the investigated efficacy pre-infection applications preventative medication larval through lungs. A third aim was to determine if adult cats infected with T. developed disease. Cats groups were administered five doses L3 larvae. Four-month-old specific pathogen free (SPF) kittens...
Background The aortic valve of the heart experiences constant mechanical stress under physiological conditions. Maladaptive injury responses contribute to development valvular disease. Here, we test hypothesis that MG 53 (mitsugumin 53), an essential cell membrane repair protein, can protect cells from and fibrocalcific remodeling processes associated with Methods Results We found is expressed in pig human patient valves observed disease aged Mg53-/- mice. Aortic mice showed compromised...
One key factor that limits resolution of single-molecule superresolution microscopy relates to the localization accuracy activated emitters, which is usually deteriorated by two factors. originates from background noise due out-of-focus signals, sample auto-fluorescence, and camera acquisition noise; other low photon count emitters at a single frame. With fast rate, can last multiple frames before they transiently switch off or permanently bleach. Effectively incorporating temporal...
Abstract Ischemic injury to the heart causes a loss of mitochondria function due an increase in oxidative stress. MG53, also known as TRIM72, is highly expressed striated muscle and essential repair damage plasma membrane. We have shown that mg53-/- mice are more susceptible ischemia-reperfusion injury, whereas treatment with exogenous recombinant human MG53 (rhMG53) reduces both infarct restores cardiac function. This study assesses whether protects repairs after stress associated...
The aortic valve of the heart experiences constant mechanical stress under physiological conditions. Maladaptive injury responses contribute to development valvular disease (VHD). Here we test hypothesis that MG53, an essential cell membrane repair protein, can protect cells from and fibrocalcific remodeling processes associated with VHD. We found MG53 is expressed in pig human patient valves observed aged Mg53 − / mice. Aortic mice showed compromised integrity. In vitro studies demonstrated...
Introduction: Ischemic injury to the heart induces mitochondrial dysfunction due an increase in oxidative stress. MG53, also known as TRIM72, is highly expressed striated muscle and essential for repairing damaged plasma membranes by interacting with membrane lipid phosphatidylserine. We have previously shown that mg53-/- mice are more susceptible ischemia-reperfusion injury, treatment exogenous recombinant human MG53 (rhMG53) reduces infarct damage, restores cardiac function preserves...