A5051538476- Cardiac Valve Diseases and Treatments
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Nuclear Structure and Function
- Muscle Physiology and Disorders
- interferon and immune responses
- Aortic Disease and Treatment Approaches
- Diabetes and associated disorders
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Vitamin K Research Studies
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Cardiovascular Health and Risk Factors
- Cancer, Stress, Anesthesia, and Immune Response
- Artificial Intelligence in Healthcare and Education
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Animal Diversity and Health Studies
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Ocular Surface and Contact Lens
- Medication Adherence and Compliance
The Ohio State University
2014-2024
The Ohio State University Wexner Medical Center
2014-2021
Lung Institute
2015-2019
Ohio State University Hospital
2017
Gwinnett Medical Center
2017
University of Colorado Anschutz Medical Campus
2017
Azusa Pacific University
2017
Denver Health Medical Center
2017
University of Colorado Denver
2017
Cancer Genetics (United States)
2017
Rationale: Duchenne muscular dystrophy is a severe inherited form of caused by mutations in the reading frame dystrophin gene disrupting its protein expression. Dystrophic cardiomyopathy leading cause death patients, and currently no effective treatment exists to halt progression. Recent advancement genome editing technologies offers promising therapeutic approach restoring However, impact this on cardiac function has yet be evaluated. Therefore, we assessed efficacy CRISPR (clustered...
MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show present in blood circulation acts as myokine to facilitate tissue injury-repair and regeneration. Transgenic mice with sustained elevation of bloodstream (tPA-MG53) have healthier longer life-span when compared littermate wild type mice. The tPA-MG53 normal glucose handling insulin signaling skeletal muscle, does not deleterious impact on db/db More importantly, display...
Abstract TRIM family proteins play integral roles in the innate immune response to virus infection. MG53 (TRIM72) is essential for cell membrane repair and believed be a muscle-specific protein. Here we show human macrophages express MG53, protein expression reduced following Knockdown of leads increases type I interferon (IFN) upon knockout mice infected with influenza comparable titres wild mice, but display increased morbidity accompanied by more accumulation CD45+ cells elevation IFNβ...
Abstract Mesenchymal stem cell‐based therapy has emerged as a promising approach for the treatment of peripheral arterial disease. The purpose this study was to examine potential effects human placenta‐derived mesenchymal cells ( PMSC s) on mouse hindlimb ischemia. s were isolated from placenta tissue and characterized by flow cytometry. An in vivo surgical ligation‐induced murine limb ischemia model generated with fluorescent dye CM ‐DiI) labelled delivered via intramuscular injection. Our...
SUMMARY The occurrence of insulin in the developing human pancreatic islet was investigated histochemically and by immunoassay. A parallel histochemical study enzymes each foetal pancreas also made. Oxidative phosphatases, glucose-6-phosphatase acid phosphatase were localized cells from foetuses 80 mm. crown-rump (CR) length onwards. Insulin demonstrated both fluorescent antibody technique immunoassay extracts all over CR length. No present extract a 35 foetus. Since β-granulation occurred...
The cornea plays an important role in transmitting light and providing protection to the eye, but is susceptible injury infection. Standard treatments for corneal wounds include topical lubricants, antibiotics, bandage contact lens, surgery. However, these measures are often ineffective. Here we show that MG53, a protein with essential cell membrane repair, contributes injury-repair process. Native MG53 present epithelia, tear film, aqueous humor, suggesting its potential function...
Metabolic syndrome is a cluster of risk factors, such as obesity, insulin resistance, and hyperlipidemia that increases the individual's likelihood developing cardiovascular diseases. Patients inflicted with metabolic disorders also suffer from tissue repair defect. Mitsugumin 53 (MG53) protein essential to cellular membrane repair. It facilitates nucleation intracellular vesicles sites disruption create patches, contributing regenerative capacity skeletal cardiac muscle tissues upon injury....
Regulatory single-nucleotide polymorphisms (rSNPs) alter gene expression. Common approaches for identifying rSNPs focus on sequence variants in conserved regions; however, it is unknown what fraction of undetectable using this approach. We present a systematic analysis expression variation at the level Saccharomyces cerevisiae GAL1-10 regulatory region. exhaustively mutated nearly every base and measured each variant with sensitive dual reporter assay. observed an change 7% (43/582) bases...
Background The aortic valve of the heart experiences constant mechanical stress under physiological conditions. Maladaptive injury responses contribute to development valvular disease. Here, we test hypothesis that MG 53 (mitsugumin 53), an essential cell membrane repair protein, can protect cells from and fibrocalcific remodeling processes associated with Methods Results We found is expressed in pig human patient valves observed disease aged Mg53-/- mice. Aortic mice showed compromised...
The renin-angiotensin-aldosterone system (RAAS) and adiposity measures are independently associated with the development of diabetes in African American (AA) adults. However, studies have not examined combined interaction between RAAS relation to risk AA
Peripheral artery disease (PAD) is a major health burden in the world. Stem cell-based therapy has emerged as an attractive treatment option regenerative medicine. In this study, we sought to test hypothesis that stem can ameliorate ischemia induced limb injury.We isolated mesenchymal cells derived from human placentas (PMSCs) and intramuscularly transplanted them into injured hind limbs. Treatment with PMSCs reduced acute muscle fibers apoptosis by ischemia.PMSC significantly enhanced...
Timely follow-up after hospitalization for heart failure (HF) is recommended. However, suboptimal, especially in lower socioeconomic groups. Patient-centered solutions facilitating post-HF have not been extensively evaluated.Face-to-face surveys were conducted between 2015 and 2016 among 83 racially diverse adult patients (61% African American, 34% Caucasian, 5% Other) hospitalized HF at a university hospital centered low-income area of Columbus, Ohio. Patient perceptions methods to...
The artificial intelligence (AI) revolution in health care, particular primary is being emphasized worldwide.[1][1]-[4][2] Alongside discussions about the transformational potential of AI apprehension and skepticism due to its propensity for shortcomings (eg, privacy liability),[1][1
Mitsugumin 53 (MG53) is a protein essential in cellular membrane repair. It facilitates the nucleation of intracellular vesicles to sites disruption create repair patches, contributing regenerative capacity striated muscles upon injury. A member TRIM family, MG53 also an E3 ligase down-regulation insulin receptor substrate-1 (IRS-1) signaling. study indicated this property as problematic development metabolic syndrome. In light discussion, we decided investigate effect disorders on activity....
We report a complex case of multivessel CAD in patient with porcelain aorta and high-grade left subclavian artery stenosis. Utilizing staged stent placement next-day plan for four-vessel, on-pump CABG ascending aortic replacement, this highlights an organized approach to diagnosing dealing heavily calcified while describing stepwise algorithm deal calcifications prior initiating cardiac surgery.
Introduction: Immune checkpoint inhibitors (ICIs) are commonly used as anticancer agents linked with dramatic antitumor response but associated cardiotoxicity. Recent isolated reports have suggested ICIs may link hypertension (HTN) after years of treatment. Yet, the timing and long-term ramifications this HTN unknown. Methods: From a large cohort well-phenotyped cancer patients treated from 2011-2022, we assessed incidence new or worsened [systolic blood pressure (SBP) ≥130 mmHg (or in...
Background Structural racism is an upstream influencer of social determinants health, which impact cardiovascular disease (CVD) death rates. The association between structural and CVD rates has not been conclusively quantified, this may vary by race/ethnicity. Method Year 2020 census data on disparities in income, wealth, education, employment, digital access segregation were available at the block group level used to quantify racism’s effects. Data from each its 9 nearest neighbors compute...
The question has often been asked whether insulin produced by the foetal pancreas passes across placenta into maternal circulation. amelioration of diabetes mellitus in mother which observed during pregnancy made this clinical importance. Among studies to investigate passage are those Davies & Lacy (1957) and Goodner Freinkel (1961). injected large doses rabbits but failed observe a significant fall blood sugar level. [131I]insulin pregnant rats detect radioactive foetus; they also reported...
Dietary patterns that promote chronic systemic inflammation, hyperinsulinemia, or hyperglycemia may influence type 2 diabetes (T2D) risk. We evaluated an empirical dietary index for hyperinsulinemia (EDIH), inflammatory pattern (EDIP), glycemic (GI), and load (GL), risk of T2D among US postmenopausal women. EDIH EDIP assess the insulinemic potential habitual diets, irrespective macronutrient content, are based on plasma concentrations insulin response biomarkers, respectively. The GI GL...
Purpose: Chest pain represents one of the most common reasons for a visit to emergency department accounting ~10% all visits. Of these only 45% represented true acute coronary syndromes (ACS) (stable angina, unstable angina or myocardial infarction (MI)). The current methods detect ACS have clinic delay several hours and hence it is focus our experiments explore novel diagnostic biomarker that can more rapidly reliably. Methods Results: In order establish library potential biomarkers, we...