A5033214058- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Veterinary Equine Medical Research
- Veterinary Oncology Research
- Blood properties and coagulation
- Blood groups and transfusion
- Vascular anomalies and interventions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Infectious Diseases and Mycology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Erythrocyte Function and Pathophysiology
- Parasitic Diseases Research and Treatment
- Glycosylation and Glycoproteins Research
- Parasites and Host Interactions
- Insects and Parasite Interactions
- Infrared Thermography in Medicine
- Helminth infection and control
- Restraint-Related Deaths
- Child Abuse and Related Trauma
- Hemophilia Treatment and Research
- Lysosomal Storage Disorders Research
- Oral and Maxillofacial Pathology
- Animal health and immunology
- Head and Neck Anomalies
- Thermoregulation and physiological responses
Auburn University
2007-2024
Versiti Blood Center of Wisconsin
2023
Abstract Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. less commonly affects cats but an important cause of mortality and treatment‐associated morbidity both species. remains a diagnosis exclusion for which diagnostic guidelines are lacking. Primary, or non‐associative, ITP refers to autoimmune platelet destruction. Secondary, associative, arises response underlying disease trigger. However, evidence comorbidities serve as triggers has not...
GM1 gangliosidosis is a fatal neurodegenerative disease that affects individuals of all ages. Favorable outcomes using adeno-associated viral (AAV) gene therapy in mice and cats have prompted consideration human clinical trials, yet there remains paucity objective biomarkers to track status. We developed panel blood, urine, cerebrospinal fluid (CSF), electrodiagnostics, 7 T MRI, magnetic resonance spectroscopy cats—either untreated or AAV treated for more than 5 years—and compared them...
A controlled, blind study was conducted to define the initial inflammatory response and lung damage associated with death of precardiac stages Dirofilaria immitis in cats as compared adult heartworm infections normal cats. Three groups six each were used: UU: uninfected untreated controls; PreS I: infected 100 D. L3 by subcutaneous injection treated topically selamectin 32 2 days pre-infection once monthly for 8 months); IU: left untreated. Peripheral blood, serum, bronchial lavage, thoracic...
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the glycoprotein complex IIb-IIIa (integrin α IIb β 3 ). The subunits are encoded separate genes and both must be expressed for stable to form on surface; therefore, either gene can result GT.
Abstract A 9‐month‐old male G reat D ane had progressive generalized nodular dermatopathy for several months. There were > 100 raised, alopecic, firm, painful nodules throughout the skin. Aspirates from lesions yielded moderate numbers of irregularly round or polygonal to spindle‐shaped cells with mild anisocytosis and few inflammatory cells, cytologic interpretation was proliferation mesenchymal histiocytic cells. On histopathologic examination, composed densely packed sheets...
A 17-year-old Peruvian Paso mare was evaluated for bilateral epistaxis that had been present at least 3 years. The mild anemia, platelet count within the reference interval, unremarkable coagulation times, and a negative Coggins test. On endoscopic examination, structural abnormalities were not observed in nasal cavities, pharynx, larynx, trachea, or either guttural pouch, but petechiation noted mucosa. Additional tests revealed prolonged cutaneous bleeding time, normal concentration of von...
Abstract An EDTA ‐anticoagulated blood sample collected from a 1.5‐year‐old, intact male, English Bulldog was submitted for CBC . The data and smear evaluation revealed borderline high hematocrit (54%, reference interval 37–55%), inappropriate rubricytosis, moderate leukopenia due to both mature neutropenia lymphopenia, mild thrombocytopenia. Numerous leukocytes showed evidence of karyolysis, pyknosis, karyorhexis, apoptotic bodies were frequent in the background. Many neutrophils had...
Acidemia in sick or injured horses is often due to lactic acid accumulation. Alterations platelet function and hemostasis are among numerous deleterious effects caused by decreased physiologic pH.We aimed evaluate the effect of hyperlactatemia resultant acidemia on aggregation equine whole blood using impedance aggregometry.Platelet was measured Multiplate analyzer from 34 healthy at baseline after vitro addition adjust pH. Platelet each sample quantified area under curve measurement...
A controlled, blind research study was conducted to define the innate response of lungs in specific pathogen free (SPF) cats intravenous (n=10) or subcutaneous (n=4) administration homogenate adult Dirofilaria immitis from donor dogs compared with lung control (n=6). There no difference that received heartworm IV for 18 days treated doxycycline 1 month given untreated dogs. Cats did not develop clinical signs, and radiographic changes were noted. SC at lower concentration than groups...
A 2-year-old, female intact, mixed-breed dog was presented to the Bailey Small Animal Teaching Hospital at Auburn University for investigation of lifelong, intermittent petechial hemorrhage. Historically, also had excessive gingival bleeding during tooth eruption. The found as a stray and 1 litter puppies. male sibling reported have similar history ecchymotic hemorrhages its owner later contacted brought teaching hospital platelet aggregation studies. Before referral, managed by referring...
Understanding SARS-CoV-2 epidemiology in companion animals is critical for evaluating their role viral transmission and potential as sentinels human infections. This large-scale serosurvey analyzed serum samples from 706 cats 2,396 dogs collected across the USA 2023 using a surrogate virus neutralization test (sVNT) to detect antibodies. Overall, 5.7% of 4.7% tested positive antibodies, with younger (under 12 months) showing significantly lower seropositivity rates (p = 0.0048)....
Background: Von Willebrand disease (VWD) is a common inherited bleeding disorder often caused by variants within the von factor (VWF) gene.Aims: To characterize candidate VWF in type 1, 2 and 3 VWD elucidate pathogenicity using clinical, computational, familial segregation functional data.
Background:The pegylated aptamer BT200 binds to the A1 domain of VWF and significantly prolongs half-life in vivo.Although mechanism(s) involved have not been defined, LRP1 scavenger receptor contributes physiological clearance.Aims: To determine molecular mechanisms through which extends half-life.Methods: Binding full-length selected truncations bone marrow-derived macrophages (BMDM) was assessed by flow cytometry presence or absence BT200.Immunosorbent plate-binding assays were used...