Yvonne L. Latour
A5027146256- Polyamine Metabolism and Applications
- Helicobacter pylori-related gastroenterology studies
- Lysosomal Storage Disorders Research
- Gut microbiota and health
- Genomics and Rare Diseases
- Amino Acid Enzymes and Metabolism
- Probiotics and Fermented Foods
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Cellular transport and secretion
- Escherichia coli research studies
- Glycosylation and Glycoproteins Research
- Genetics and Neurodevelopmental Disorders
- Sulfur Compounds in Biology
- Microscopic Colitis
- RNA and protein synthesis mechanisms
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Erythrocyte Function and Pathophysiology
- Bone health and treatments
- Studies on Chitinases and Chitosanases
- Gastrointestinal disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
Vanderbilt University Medical Center
2019-2024
National Human Genome Research Institute
2015-2023
National Institutes of Health
2015-2023
Vanderbilt University
2020-2023
Bipar
2022
The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including bowel disease (IBD). IL23R enriched intestinal Tregs, yet whether IL-23 modulates Tregs remains unknown. Here, investigating IL-23R signaling specifically, we show that colonic highly express Il23r compared with from other compartments their frequency reduced upon administration impairs Treg suppressive function. Similarly, increased mice lacking specifically exhibits a...
GM1 gangliosidosis is a fatal neurodegenerative disease that affects individuals of all ages. Favorable outcomes using adeno-associated viral (AAV) gene therapy in mice and cats have prompted consideration human clinical trials, yet there remains paucity objective biomarkers to track status. We developed panel blood, urine, cerebrospinal fluid (CSF), electrodiagnostics, 7 T MRI, magnetic resonance spectroscopy cats—either untreated or AAV treated for more than 5 years—and compared them...
GM1 gangliosidosis is an autosomal recessive neurodegenerative disorder caused by the deficiency of lysosomal β-galactosidase (β-gal) and resulting in accumulation ganglioside. The disease spectrum ranges from infantile to late onset uniformly fatal, with no effective therapy currently available. Although animal models have been useful for understanding pathogenesis exploring therapeutic targets, relevant human central nervous system (CNS) model has available study its early pathogenic...
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer N-moiety spermidine to lysine-50 residue eukaryotic translation initiation factor 5A (EIF5A) form amino acid hypusine. Hypusinated EIF5A (EIF5AHyp) transports specific mRNAs ribosomes for translation. We show that DHPS is induced in macrophages by two gastrointestinal pathogens, Helicobacter pylori and Citrobacter rodentium, resulting enhanced...
Macrophages play a crucial role in the inflammatory response to human stomach pathogen Helicobacter pylori, which infects half of world's population and causes gastric cancer. Recent studies have highlighted importance macrophage immunometabolism their activation state function. We demonstrated that cysteine-producing enzyme cystathionine γ-lyase (CTH) is upregulated humans mice with H. pylori infection. Here, we show induction CTH macrophages by promoted persistent inflammation. Cth–/– had...
Background GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1, encoding β‐galactosidase. The range of severity from type I infantile disease, lethal early childhood, to III adult onset, resulting gradually progressive neurological symtpoms adulthood. intermediate group patients has been recently classified as having II late subtype with onset symptoms at one three years age or juvenile symptom 2–10 years. To characterize disease and progression, six Late nine were...
Helicobacter pylori is the primary cause of gastric cancer, and there a need to discover new molecular targets for therapeutic intervention in H. disease progression. We have previously shown that spermine oxidase (SMOX), enzyme catabolizes back-conversion polyamine spermidine, upregulated during infection associated with increased cancer risk humans. sought determine direct role SMOX carcinogenesis infection. In this study, we demonstrate transgenic FVB/N insulin-gastrin (INS-GAS) mice...
The reverse transsulfuration pathway is the major route for metabolism of sulfur-containing amino acids. role this metabolic in macrophage response and function unknown. We show that enzyme cystathionine γ-lyase (CTH) induced macrophages infected with pathogenic bacteria through signaling involving phosphatidylinositol 3-kinase (PI3K)/MTOR transcription factor SP1. This results synthesis cystathionine, which facilitates survival pathogens within myeloid cells. Our data demonstrate expression...
Inflammatory bowel disease (IBD) is characterized by severe gastrointestinal inflammation, but many patients experience extra-intestinal disease. Bone loss one common manifestation of IBD that occurs through dysregulated interactions between osteoclasts and osteoblasts. Systemic inflammation has been postulated to contribute bone loss, the specific pathologic mechanisms have not yet fully elucidated. We hypothesized intestinal leads increased abundance altered function osteoclast progenitors.
Pathogenic enteric Escherichia coli present a significant burden to global health. Food-borne enteropathogenic E. (EPEC) and Shiga toxin-producing (STEC) utilize attaching effacing (A/E) lesions actin-dense pedestal formation colonize the gastrointestinal tract. Talin-1 is large structural protein that links actin cytoskeleton extracellular matrix though direct influence on integrins. Here we show mice lacking talin-1 in intestinal epithelial cells (Tln1Δepi) have heightened susceptibility...
One of the major contributors to child mortality in world is diarrheal diseases, with an estimated 800,000 deaths per year. Many pathogens are causative agents these illnesses, including enteropathogenic or enterohemorrhagic forms
Abstract Colonization by Helicobacter pylori is associated with gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response pathogen affect outcome disease. One major component mucosal H. activation a strong but inefficient immune that fails control infection frequently causes tissue damage. We have shown polyamines can regulate pylori–induced inflammation. Chemical inhibition...
Biomarkers currently available for the diagnosis, prognosis, and therapeutic monitoring of GM1 gangliosidosis type 2 (GM1T2) disease are mainly limited to those discovered in targeted proteomic-based studies. In order identify establish new, predominantly low-molecular-mass biomarkers this disorder, we employed an untargeted, multi-analyte approach involving high-resolution 1H NMR analysis coupled a range multivariate computational intelligence technique (CIT) strategies explore biomolecular...
Abstract Cystathionine γ-lyase (CTH) is a critical enzyme in the reverse transsulfuration pathway, major route for metabolism of sulfur-containing amino acids, notably converting cystathionine to cysteine. We reported that CTH supports gastritis induced by pathogen Helicobacter pylori . Herein our aim was investigate role colonic inflammation. First, we found colon mucosa mice with dextran sulfate sodium-induced colitis. Expression completely absent Cth –/– mice. observed clinical and...
Abstract INTRODUCTION Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is highly expressed in activated macrophages and converts cis-aconitate to itaconate, which contributes the antimicrobial activity of macrophages. The role ACOD1 intestinal inflammation remains unknown. Therefore, we investigated during colitis induced by Citrobacter rodentium (C. rodentium), a murine bacterial pathogen used model pathogenesis enteropathogenic Escherichia coli, dextran sulfate sodium (DSS) epithelial...