A5091702762- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood groups and transfusion
- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myocardial Infarction Research
- Cardiovascular Conditions and Treatments
- Blood transfusion and management
- Blood properties and coagulation
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
- Abdominal Trauma and Injuries
- Clinical Laboratory Practices and Quality Control
- Streptococcal Infections and Treatments
- Cell Adhesion Molecules Research
- Antibiotic Use and Resistance
- Hemodynamic Monitoring and Therapy
- Animal health and immunology
- Erythrocyte Function and Pathophysiology
- Complement system in diseases
- Gut microbiota and health
- Veterinary Oncology Research
- Cardiac Arrest and Resuscitation
New York State College of Veterinary Medicine
2014-2025
Cornell University
2016-2025
Christian Medical College & Hospital
2023
Christian Medical College
2023
Ithaca College
2021
University of Bristol
2012-2015
Royal Veterinary College
2009-2014
University of Illinois System
2014
University of Liverpool
2003-2005
Immune‐mediated hemolytic anemia (IMHA) is an important cause of morbidity and mortality in dogs. IMHA also occurs cats, although less commonly. considered secondary when it can be attributed to underlying disease, as primary (idiopathic) if no found. Eliminating diseases that may attenuate or stop immune‐mediated erythrocyte destruction, adverse consequences long‐term immunosuppressive treatment avoided. Infections, cancer, drugs, vaccines, inflammatory processes causes IMHA. Evidence for...
To systematically examine the evidence relating to performance of rotational viscoelastic testing in companion animals, develop assay guidelines, and identify knowledge gaps.Multiple questions were considered within 5 parent domains, specifically system comparability, sample handling, activation test protocol, definitions data reporting, nonstandard assays. Standardized, systematic evaluation literature was performed. Relevant articles categorized according level assessed for quality....
Immune‐mediated hemolytic anemia (IMHA) causes severe in dogs and is associated with considerable morbidity mortality. Treatment various immunosuppressive antithrombotic drugs has been described anecdotally previous studies, but little consensus exists among veterinarians as to the optimal regimen employ maintain after diagnosis of disease. To address this inconsistency provide evidence‐based guidelines for treatment IMHA dogs, we identified extracted data from studies published veterinary...
Background: Dogs with protein‐losing enteropathy (PLE) have previously been reported to present thromboembolism; however, the prevalence and pathogenesis of hypercoagulability in dogs PLE not investigated so far. Hypothesis: are hypercoagulable compared healthy control dogs. Animals: Fifteen PLE. Thirty served as controls (HC). Methods: A prospective study was performed including 15 All were scored using canine chronic activity index (CCECAI). Thromboelastography (TEG) other measures...
To examine systematically the evidence on sample acquisition and handling for thrombo elastography (TEG) rotational thromboelastometry (ROTEM) viscoelastic point of care instruments to identify knowledge gaps.Six questions were considered, addressing sampling site, collection system, anticoagulant, procedure, storage. Standardized, systematic evaluation literature was performed. Relevant articles categorized according level (LOE). Consensus developed regarding conclusions application...
Abstract Objectives Thrombosis is a well‐recognized phenomenon in dogs and cats with significant impact on morbidity mortality. Despite growing awareness of thrombosis increased use antithrombotic therapy, there little information the veterinary literature to guide anticoagulant antiplatelet medications. The goal Domain 1 was explore association between disease number conditions identified as potential risk factors current literature, provide basis for prescribing recommendations. Design A...
Abstract Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. less commonly affects cats but an important cause of mortality and treatment‐associated morbidity both species. remains a diagnosis exclusion for which diagnostic guidelines are lacking. Primary, or non‐associative, ITP refers to autoimmune platelet destruction. Secondary, associative, arises response underlying disease trigger. However, evidence comorbidities serve as triggers has not...
Background: The cytokine response in immune‐mediated hemolytic anemia (IMHA) is poorly characterized and correlation with outcome unknown. Hypothesis/Objectives: To determine if activity correlated dogs IMHA. Animals: Twenty primary IMHA 6 control dogs. Methods: Prospective study on blood sampling at admission. Serum of interleukin‐2 (IL‐2), IL‐4, IL‐6, IL‐7, IL‐8, IL‐10, IL‐15, IL‐18, monocyte chemoattractant protein‐1 (MCP‐1), granulocyte‐macrophage colony stimulating factor (GM‐CSF),...
To systematically examine evidence surrounding definitions and reporting of data for viscoelastic testing in veterinary medicine.Standardized, systematic evaluation the literature, categorization relevant articles according to level quality, development consensus on conclusions application concepts clinical practice.Academic referral medical centers.Databases searched included Medline, CAB abstracts, Google Scholar.All 4 standard thromboelastography (TEG) rotational thromboelastometry...
To systematically examine the evidence on activating agents and test protocols for thrombelastography (TEG) rotational thrombelastometry (ROTEM) viscoelastic point-of-care instruments to identify knowledge gaps.Ten questions were considered, primary question addressed use of secondary assay temperature, length analysis, pipetting, sample volume, reproducibility, quality controls. Standardized, systematic evaluation literature was performed. Relevant articles categorized according level...
Abstract Objective To investigate the use of plasma cell‐free DNA (cfDNA) and nucleosome concentrations as prognostic biomarkers in canine sepsis. Design Prospective, observational cohort study conducted from June 2015 to February 2016. Setting University teaching hospital. Animals Forty‐five dogs with sepsis, 10 nonseptic systemic inflammatory response syndrome (nSIRS), 15 healthy controls were consecutively enrolled followed hospital discharge. Patients eligible for enrollment if they met...
Background Outcome prediction in dogs with immune‐mediated hemolytic anemia ( IMHA ) is challenging and few prognostic indicators have been consistently identified. Objectives An online case registry was initiated to: prospectively survey canine presentation management the British Isles; evaluate 2 previously reported illness severity scores, Canine Hemolytic Anemia Score CHAOS Toky o to identify independent markers. Animals Data from 276 primary across 10 referral centers were collected...
Objectives To evaluate the feasibility of CT pulmonary angiography for identification naturally occurring thromboembolism in dogs using predefined diagnostic criteria and to assess ability echocardiography, cardiac troponins, D‐dimers kaolin‐activated thromboelastography predict presence dogs. Methods Twelve with immune‐mediated haemolytic anaemia evidence respiratory distress were prospectively evaluated. Dogs sedated immediately before intravenous butorphanol. Spiral was performed a 16...
Background: Calcium disorders are common in small animals, but few studies have investigated the etiology of ionized hypercalcemia and hypocalcemia large populations. This study aimed to determine incidence calcium dogs cats treated at a tertiary referral clinic describe associated diseases. Methods: An electronic database electrolyte analyses conducted Cornell University Hospital for Animals from 2007 2017 was searched. Dogs with or were identified based on institution reference intervals....
Abstract Objective To discuss the definitions of sepsis in human and veterinary medicine. Design International, multicenter position statement on need for consensus Setting Veterinary private practice university teaching hospitals. Animals Dogs cats. Interventions None. Measurements Main Results Sepsis is a life‐threatening condition associated with body's response to an infection. In medicine, has been defined by 3 occasions, most recently 2016. there little uniformity how no identify it...
Abstract Management of immune thrombocytopenia (ITP) in dogs and cats is evolving, but there are no evidence‐based guidelines to assist clinicians with treatment decisions. Likewise, the overall goals for ITP have not been established. Immunosuppressive doses glucocorticoids first line treatment, optimal regimens beyond remain uncertain. Additional options include secondary immunosuppressive drugs such as azathioprine, modified cyclosporine, mycophenolate mofetil, usually selected based on...
Abstract Diagnosing coagulation disorders can be challenging in primary care practice due to the complexity of pathways, confusing terminology, and special requirements for sample collection. This article highlights common problems identified submissions testing provides solutions help clinicians overcome these obstacles. Blood collection procedures optimal quality are described, diagnostic algorithms presented that guide test selection facilitate interpretation results successful patient management.