A5107072015- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Complement system in diseases
- Hemostasis and retained surgical items
- Cardiovascular Conditions and Treatments
- Bacterial Identification and Susceptibility Testing
- Cardiac Arrest and Resuscitation
- Abdominal Trauma and Injuries
- Acute Kidney Injury Research
- Renal Diseases and Glomerulopathies
- Infective Endocarditis Diagnosis and Management
- Dialysis and Renal Disease Management
- Neuroscience of respiration and sleep
- Pericarditis and Cardiac Tamponade
- Veterinary Medicine and Surgery
- Trauma and Emergency Care Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Renal function and acid-base balance
- Trauma Management and Diagnosis
- Hemodynamic Monitoring and Therapy
- Veterinary Orthopedics and Neurology
- Foreign Body Medical Cases
- Sympathectomy and Hyperhidrosis Treatments
- Veterinary Oncology Research
- Veterinary Pharmacology and Anesthesia
Royal Veterinary College
2014-2024
University of London
2019-2024
Mother Hospital
2018
Acute kidney injury (AKI) is defined as an to the renal parenchyma, with or without a decrease in function, reflected by accumulation of uremic toxins altered urine production (i.e., increased decreased). AKI might result from any several factors, including ischemia, inflammation, nephrotoxins, and infectious diseases. can be community- hospital-acquired. The latter was not previously considered common cause for animals; however, recent evidence suggests that prevalence hospital-acquired...
Abstract Objective To determine if absolute plasma lactate concentration or clearance in dogs with septic peritonitis is associated morbidity mortality. Design Retrospective cohort study from 2007 to 2012. Setting University teaching hospital. Animals Eighty‐three were included. Patients had at least 1 measurement during the course of hospitalization. Results Sixty‐four percent patients survived discharge, 22% euthanized, and 14% died Plasma >2.5 mmol/L on admission (29% patients) was...
Abstract Objective To discuss the definitions of sepsis in human and veterinary medicine. Design International, multicenter position statement on need for consensus Setting Veterinary private practice university teaching hospitals. Animals Dogs cats. Interventions None. Measurements Main Results Sepsis is a life‐threatening condition associated with body's response to an infection. In medicine, has been defined by 3 occasions, most recently 2016. there little uniformity how no identify it...
Background Neutrophil gelatinase‐associated lipocalin ( NGAL ) is an early indicator of acute kidney injury AKI in dogs and its use has not been evaluated with sepsis. Animals Fifteen sepsis requiring laparotomy (study dogs) 10 undergoing surgery for intervertebral disc disease (control dogs). Objective To determine whether increases emergency it correlated development survival. Methods Longitudinal study conducted at a referral teaching hospital. Serum neutrophil sNGAL ), urinary normalized...
To expand the number of conditions and interventions explored for their associations with thrombosis in veterinary literature to provide basis prescribing recommendations.A population exposure comparison outcome format was used represent patient, exposure, comparison, outcome. Population Exposure Comparison Outcome questions were distributed worksheet authors who performed comprehensive searches, summarized evidence, created guideline recommendations that reviewed by domain chairs. The...
Abstract Background Bleeding tendencies can occur with uremia. Objectives To characterize primary hemostatic function in dogs acute kidney injury (AKI). Animals Ten International Renal Interest Society AKI grade III or above and 10 healthy controls. Methods Prospective study comparing PCV, platelet count, aggregometry (Multiplate), von Willebrand factor antigen to collagen binding activity ratio (vWF:Ag:vWF:CBA) 2 groups of (AKI group versus controls). Buccal mucosal bleeding time was...
Background: Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs are lacking and likely differ from those of healthy dogs. The aim this work is to describe a population PK model for intravenous (IV) amoxicillin-clavulanic acid (AMC) both sick simulate range clinical dosing scenarios compute PK/PD cutoffs populations. Methods: This study used prospective trial normal Twelve client-owned hospitalized the intensive care unit (ICU) received IV AMC 20 mg/kg every 8 h (0.5-h...
To assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional novel serum urinary biomarkers.Prospective cohort study conducted July 2018 April 2019.University teaching hospital.Nineteen CPB with preoperative creatinine <140 μmol/L (<1.6 mg/dl).Blood urine samples were obtained at 4 time points: preoperatively following general anesthesia induction, immediately postoperatively, 2 days...
Cutaneous and renal glomerular vasculopathy (CRGV) is a rare disease affecting dogs, with recent apparent increase in prevalence since 2012 the UK. This characterized by small vessels of kidney skin, leading to thrombotic microangiopathy. The underlying etiology remains unknown although clinicopathological histological findings resemble features certain forms microangiopathy people, for which plasma exchange (PEX) considered an important component therapy. objective present study describe...
To describe the conservative management and outcome of gastrointestinal metallic sharp-pointed straight foreign bodies in dogs cats.Clinical records cats presented to a university teaching hospital between 2003 2021 with (e.g. needles, pins, nails) were reviewed. Conservative was defined as leaving body situ. Cases excluded if identified outside tract (including oropharynx oesophagus) or it removed by endoscopy surgery first treatment choice. Patient signalment, presenting complaint,...
To describe the use of pericardial catheters in dogs with effusion (PE), and detail any associated adverse events.Retrospective study.University teaching hospital.Eighteen client-owned that had placed for fluid drainage between May 2007 January 2015.None.All were within 5 hours presentation, usually 1 hour (median 72.5 min, range 45-300 min). Ten 18 cases sedated butorphanol, 4 additional midazolam. Four positioned single only immediately removed. The other 14 remained situ a median (range...
A dog presenting with scleral haemorrhage and neck pain was diagnosed Angiostrongylus vasorum on direct faecal smear. Thromboelastography (with the addition of tissue plasminogen activator) revealed evidence hypocoagulability hyperfibrinolysis. The administration fresh frozen plasma tranexamic acid associated resolution a hypocoagulable hyperfibrinolytic state, as well clinical improvement.
Abstract This case report details the clinical investigation of an 11‐month‐old, entire, male Cockapoo, who presented with acute left forebrain signs associated suspected intra‐cranial haemorrhage due to Angiostrongylus vasorum . Initial investigations failed identify a coagulopathy using traditional coagulation testing. Subsequent viscoelastic testing Viscoelastic Coagulation Monitor (VCM Vet, Entegrion) identified hypocoagulable, hyperfibrinolytic trace. Anti‐fibrinolytic treatment...
Abstract Objective To describe the successful management of a dog with acute respiratory distress syndrome secondary to inhalant toxin exposure. Case summary An 8‐year‐old male neutered Greyhound was referred severe 56 hours after exposure an aerosol toxicant. The patient developed difficulties requiring veterinary attention within 12 initial Treatment at referral hospital included mechanical ventilation and supportive care. discharged 5 days admission hospital. New or unique information...
To compare the safety and efficacy of pericardial catheter placement with needle pericardiocentesis in dogs effusion (PE) DESIGN: Prospective, randomized clinical trial.University teaching hospital.Thirty client-owned requiring between January 2017 August 2019.Dogs were to undergo PE drainage via indwelling (catheter group) followed by elective every 4-6 hours or (needle repeated as necessary.Fifteen allocated group 15 group. Data collected included signalment, cause effusion, occurrence...
To describe the clinical characteristics and outcomes in a population of dogs with negative-pressure pulmonary edema (NPPE) to identify main causes disease. evaluate any associations morbidity mortality.Retrospective study.Three university teaching hospitals 2 private referral centers United Kingdom.Thirty-five client-owned presented NPPE.None MEASUREMENTS AND MAIN RESULTS: Data collected included patient characteristics, history, clinicopathological abnormalities, radiographic features,...
To describe patient recovery in dogs that had undergone mechanical ventilation (MV) and received atracurium as a continuous rate infusion (CRI).Three were treated with CRI while mechanically ventilated successfully weaned. All pediatric patients (2-3 months old) due to respiratory fatigue hypoxemia. experienced seizure activity the initial 24 h following extubation various anticonvulsant protocols; no documented seizures after 48 of discontinuation from MV.All three weaned an new onset their...
Abstract OBJECTIVE To describe the presentation, diagnosis, and treatment of 4 cases splenic torsion with associated spherocytosis. ANIMALS client-owned dogs spherocytosis torsion. CLINICAL PRESENTATION Each dog presented nonspecific clinical signs, 3 out were anemic on presentation. RESULTS The diagnosis was made abdominal ultrasound or CT confirmed during exploratory laparotomy. Spherocytosis described as occasional (patient 1), rare 2), low number (patients 4). Two survived to hospital...
Abstract Objectives To determine platelet function and assess fibrinolysis in dogs following trauma using multiple electrical impedance aggregometry a modified thromboelastographic (TEG) technique. if the severity of trauma, as assessed by Animal Trauma Triage (ATT) score clinicopathological markers shock, is associated with greater degree dysfunction fibrinolysis. Setting University teaching hospital. Animals Twenty client‐owned (occurring <24 h prior to admission blood sampling) ATT...