A5049283486- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Trauma and Emergency Care Studies
- Venous Thromboembolism Diagnosis and Management
- Viral gastroenteritis research and epidemiology
- Hemostasis and retained surgical items
- Blood properties and coagulation
- Allergic Rhinitis and Sensitization
- Cardiac Arrest and Resuscitation
- Food Allergy and Anaphylaxis Research
- Veterinary Equine Medical Research
- Proteoglycans and glycosaminoglycans research
- Urticaria and Related Conditions
- Exercise and Physiological Responses
- Hemoglobin structure and function
- Blood groups and transfusion
- Veterinary Pharmacology and Anesthesia
- Acute Ischemic Stroke Management
- Foreign Body Medical Cases
- Chemotherapy-related skin toxicity
- Chronic Kidney Disease and Diabetes
- Antimicrobial Resistance in Staphylococcus
Murdoch University
2017-2025
Platinum Group Coatings (United States)
2021
Abstract Objective : To investigate the association between synthetic colloids and biomarkers of acute kidney injury (AKI) in dogs with hemorrhagic shock. Design Experimental interventional study. Setting University. Animals Twenty‐four healthy ex‐racing Greyhounds. Interventions Anesthetized Greyhounds subjected to hemorrhage for 60 min were resuscitated 20 mL/kg fresh whole blood (FWB), 6% hydroxyethyl starch (HES) 130/0.4, 4% succinylated gelatin (GELO), or 80 isotonic crystalloid (CRYST)...
Abstract Objective To document clinical complications and intervention options associated with norepinephrine (NE) extravasation in dogs cats. Design Cases were identified between 2015 2021. Because this is an uncommon complication, the findings are compiled as a descriptive retrospective study. Setting provided from 4 universities 2 private practice groups United States, Canada, Australia. Animals Fourteen patients (13 dogs, 1 cat) that experienced events (16 total). Interventions Small...
Background: Hemorrhagic shock and volume replacement can alter coagulation. Synthetic colloids, hydroxyethyl starch (HES), gelatin, may enhance hypocoagulability. Our primary objective was to describe the effect of four fluid products on coagulation in canine hemorrhagic shock. secondary compare measurements during baseline all dogs. Methods: Anesthetized greyhounds subjected atraumatic hemorrhage for 60 min were administered 20 mL kg-1 either fresh whole blood (FWB), 6% HES 130/0.4, 4%...
To expand the number of conditions and interventions explored for their associations with thrombosis in veterinary literature to provide basis prescribing recommendations.A population exposure comparison outcome format was used represent patient, exposure, comparison, outcome. Population Exposure Comparison Outcome questions were distributed worksheet authors who performed comprehensive searches, summarized evidence, created guideline recommendations that reviewed by domain chairs. The...
Exercise-induced muscle damage (EIMD) results in the generation of reactive oxygen species (ROS), but little is known about temporal profile change ROS post-EIMD and how levels relate to onset recovery from EIMD. Our primary aim was examine effect EIMD on pattern blood level thiol-oxidised albumin, a marker oxidative stress.
Abstract Objective: To evaluate the effect of 6% hydroxyethyl starch (HES) 130/0.4, compared with a Hartmann's solution control (CRYST), on urine biomarkers acute kidney injury (AKI) in dogs prescribed fluid bolus. Design: Randomized, controlled, blinded clinical trial January 2018 to February 2019. Setting: University teaching hospital. Animals: Forty client‐owned dogs. Interventions: Dogs bolus were randomized receive at least 10 mL/kg HES or CRYST clinicians and investigators type. Study...
Abstract Background Prestorage leukoreduction of red blood cell (RBC) bags prevents accumulation pro‐inflammatory mediators and experimentally attenuates post‐transfusion inflammation in healthy dogs. However, the effect on critically ill dogs is unclear. Hypothesis Dogs transfused with leukoreduced (LR) RBC will have lower concentrations leukocytes, interleukin (IL)‐6, IL‐8, monocyte chemoattractant protein‐1 (MCP‐1), C‐reactive protein (CRP) within 24 hours compared to nonleukoreduced...
To describe the clinical features of dogs treated for suspected anaphylaxis in Perth, Western Australia.Single-centre observational case series with retrospective and prospective phases.This was a two-phase study suspicion presenting to emergency service university teaching hospital. Dogs required evidence of, appropriate treatment type 1 hypersensitivity reaction as well two or more organs affected (or cardiovascular signs alone) be included. Phase includes 186 (March 2006-December 2018). 2...
Abstract Background Fluid resuscitation is frequently required for cardiac surgical patients admitted to the intensive care unit. The ideal fluid of choice in regard efficacy and safety remains uncertain. Compared with crystalloid fluid, colloid may result less positive balance. However, some synthetic colloids are associated increased risk acute kidney injury (AKI). This study compared effects succinylated gelatin (4%) (GEL) compound sodium lactate (CSL) on urinary AKI biomarkers after...
To systematically review available evidence and establish guidelines related to the use of thrombolytics for management small animals with suspected or confirmed thrombosis.PICO (Population, Intervention, Control, Outcome) questions were formulated, worksheets completed as part a standardized systematic literature evaluation. The population interest included dogs cats (considered separately) arterial venous thrombosis. interventions assessed thrombolytics, compared no without anticoagulants...
Case report Two dogs with an oesophageal foreign body ( FB ) were diagnosed secondary pyothorax at the time of presentation. One dog was managed surgical removal, pleural lavage and thoracostomy tube placement. Following surgery, it admitted to intensive care unit for oxygen therapy, antimicrobial analgesic administration, fluid thoracic drainage enteral nutrition. The other endoscopic placement continuous suction, similar aftercare in unit. Both survived discharge from hospital. Conclusion...
The primary objective of this study was to document coagulation factor activity in canine "NEVER-FROZEN" and "THAWED" refrigerated plasma for the purposes defining recommended expiration dates. We hypothesized that NEVER-FROZEN THAWED would maintain >50% factors V (FV), VII (FVII), VIII (FVIII), IX (FIX), X (FX), von Willebrand antigen (vWF) a concentration fibrinogen above lower bound reference interval (>0.982 g/L) greater than 14 days but less 42 days.Prospective laboratory-based...
Aim To describe faecal PCR (fPCR) results and clinical findings of dogs seen at a university teaching hospital for diarrhoea. Design Retrospective case series (April 2015 to July 2018). Procedure Data were collected from the electronic medical records. extracted included signalment, history, signs, treatment, fPCR panel results, other diagnostic test antimicrobial use. Results One hundred sixty‐eight with diarrhoea had submitted. Most (115, 68.5%) 3 days or less duration. Clostridium...
To compare the hemostatic characteristics of cold-stored whole blood (CSWB) from non-greyhound dogs (NGD) and greyhound (GD) over 42 days storage, notably, platelet closure time (PCT) (NGD only), manual count (PLT) (GD ellagic acid (INTEM) tissue factor activated (EXTEM) rotational thromboelastometry, prothrombin (PT) partial thromboplastin (aPTT), fibrinogen concentration (FIB), activities factors (F) FII, FV, FVII, FVIII, FIX, FX, FXIII antigen (FXIII:Ag), von Willebrand (vWF:Ag). Whole 10...
Thawed plasma (TP) refers to defrosted fresh frozen stored refrigerated. TP is used in human medicine for the rapid provision of coagulation factors and resuscitation haemorrhagic shock, but its use dogs poorly described. The objectives this historical case series were describe reasons transfusion, treatment outcomes, adverse events associated with canine transfusions a veterinary teaching hospital. We hypothesised that would be most commonly haemorrhage secondary anticoagulant rodenticide...
Objectives To compare concentrations of biomarkers of; allergy [mast cell tryptase (MCT) and histamine], inflammation [interleukin (IL)-6,-10, and−18, CXCL8, CCL2, keratinocyte chemoattractant (KC), C-reactive protein (CRP)], endothelial glycocalyx shedding (hyaluronan), coagulation [prothrombin time, activated partial thromboplastin fibrinogen concentration, von Willebrand Factor antigen, C (PC) antithrombin (AT) activity], hepatopathy [alanine transaminase (ALT), aspartate (AST), alkaline...
Obstructive shock can be caused by any lesion leading to extraluminal compression or intraluminal occlusion of the cardiac chambers major vessels.A 12-year-old, male castrated, Border Collie cross dog presented a veterinary teaching hospital for collapse. A physical examination revealed severe vasoconstrictive and abdominal distension. Abnormalities on blood tests were consistent with systemic hypoperfusion. Cardiac underfilling, hepatomegaly distended vasculature ascites identified focused...
This retrospective observational study reports the enteric organisms detected in dogs Western Australia that had a faecal PCR (fPCR) submitted to commercial veterinary laboratory. Of 2025 fPCR results, Clostridium perfringens alpha toxin gene was most frequently (87.2%), followed by Campylobacter spp. (37.8%), canine parvovirus (10.5%), Giardia (9.7%), Salmonella (7.0%), coronavirus (2.3%), and distemper virus (0.3%). C.perfringens were common co-detected. There no statistically significant...
A 15-month-old, male neutered Staffordshire Bull Terrier cross was presented to its referring veterinarian collapsed and agonal. He immediately intubated, manually ventilated, treatment commenced for presumptive snake envenomation with two vials of Tiger/Multi-Brown Snake Antivenom (minimum 7000 units/vial). The dog transferred a referral hospital intubated. Additional diagnostics performed following arrival at the included urine venom detection kit test, which positive brown immunotype....