A5052746989- Lysosomal Storage Disorders Research
- Veterinary Oncology Research
- Neurological diseases and metabolism
- Plant-based Medicinal Research
- Bartonella species infections research
- Genetic Neurodegenerative Diseases
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Microbial infections and disease research
- Plant Toxicity and Pharmacological Properties
- Alkaloids: synthesis and pharmacology
- Virus-based gene therapy research
- Traditional and Medicinal Uses of Annonaceae
- Infectious Diseases and Mycology
- T-cell and Retrovirus Studies
- Animal Virus Infections Studies
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Hereditary Neurological Disorders
- Platelet Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- Lymphoma Diagnosis and Treatment
- Glycogen Storage Diseases and Myoclonus
- Legionella and Acanthamoeba research
- Natural product bioactivities and synthesis
North Carolina State University
2022-2025
Oniris
2014-2023
Murdoch University
2020-2022
North Central State College
2022
South Australia Pathology
2020
Université Nantes Angers Le Mans
2015
Pompe disease is a lysosomal storage disorder caused by acid-α-glucosidase (GAA) deficiency, leading to glycogen storage. The manifests as fatal cardiomyopathy in infantile form. Enzyme replacement therapy (ERT) has recently prolonged the lifespan of these patients, revealing new natural history. neurologic phenotype and persistence selective muscular weakness some patients could be attributed central nervous system (CNS) uncorrected ERT. GAA-KO 6neo/6neo mice were treated with single...
A 13-y-old, spayed female dog had regenerative anemia, lymphopenia, hypoalbuminemia, and elevated hepatic biochemical parameters. Liver biopsy revealed peliosis (hepatic sinusoidal angiectasis), frequently associated with perisinusoidal fibrosis. The was seroreactive to Bartonella antigens by indirect fluorescent antibody assays, quantitative PCR from blood identified vinsonii subsp. berkhoffii genotype II. euthanized 9 mo later because of acute decompensation. Autopsy icteric adipose...
This study reinforces the value of a One Health approach to infectious disease outbreak investigations. After onset neuropsychiatric symptoms in their son, our investigation focused on family composed mother, father, two daughters, dogs, and rabbit, all with exposures vectors (fleas ticks), rescued other animals. Between 2020 2022, members experienced illnesses that included neurological symptoms. Prolonged menorrhagia (130d) youngest daughter ultimately resolved following antibiotic...
Background In conjunction with more sensitive culture and molecular diagnostic testing modalities, simultaneous or sequential infection than 1 vector borne zoonotic pathogen is being increasingly documented in human patients. On a frequent basis, many people are exposed to apparently healthy, but infected, domestic wild animals, the arthropod vectors which these animals have co-evolved, bacterial, protozoal other pathogens for various reservoirs. Unsuspected transmission by scratch, bite,...
Abstract This case report presents a 14‐month‐old female Poodle mix with acute megakaryoblastic leukemia based on marked thrombocytosis, abnormal platelet morphology, circulating dwarf megakaryocytes, and blast cells in the blood. Bone marrow abnormalities included dysmegakaryopoiesis dygranulopoiesis, an increased number of was observed Extensive leukemic involvement also found liver, spleen, lymph nodes, lungs, kidneys, brain. The cytopathologic features were highly suggestive being...
Background Brain metastases are well known for disseminated hemangiosarcoma involving the right atrium/auricle. Case report An 8‐year‐old male Australian Shepherd Dog presented with a 3‐day history of circling to left. A neurological examination revealed obtunded mentation, hemi‐inattention, bilateral strabismus towards left side and absent physiological nystagmus. In addition, dog had muffled heart sounds on auscultation exercise‐induced weakness. Laboratory findings included...
We performed a retrospective examination of spontaneous hepatocellular carcinomas (HCCs) (primary and metastatic tumors) in 14 captive prosimians brought to the Veterinary Medical Diagnostic Laboratory North Carolina State University over period 11 years (2003 2014) characterize tumors. These animals are endangered primates; better understanding main fatal neoplasms is crucial. In addition histologic evaluation, an immunohistochemical study was also performed, using hepatocyte marker...
Obstructive shock can be caused by any lesion leading to extraluminal compression or intraluminal occlusion of the cardiac chambers major vessels.A 12-year-old, male castrated, Border Collie cross dog presented a veterinary teaching hospital for collapse. A physical examination revealed severe vasoconstrictive and abdominal distension. Abnormalities on blood tests were consistent with systemic hypoperfusion. Cardiac underfilling, hepatomegaly distended vasculature ascites identified focused...
Two captive female Parma wallabies (Macropus parma) died after a history of flaccid paraplegia. On postmortem examination, granulomatous and suppurative osteomyelitis involving the left ischium lumbosacral region, with meningeal extension at cauda equina, caseonecrotic mastitis were most significant changes. Multiple small nodules in liver spleen, an enlargement some lymph nodes central caseous necrosis also observed. Microscopically, disseminated inflammation numerous multinucleate giant...
A 14-y-old, castrated male, diabetic, domestic longhaired cat was presented for investigation of anemia. General examination revealed widespread cutaneous erythematous macules and patches. Hematology bone marrow aspiration severe regenerative anemia marked erythroid hyperplasia, respectively. Low numbers intermediate-to-large, atypical lymphocytes were observed in the blood smear aspirates. Various imaging modalities demonstrated a diffuse pulmonary bronchial pattern, multifocal mural...