A5063169275- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Pharmacological Effects and Assays
- Diet and metabolism studies
- Veterinary Medicine and Surgery
- Veterinary Equine Medical Research
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Healthcare and Venom Research
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Veterinary Pharmacology and Anesthesia
- Cardiac Ischemia and Reperfusion
- Venomous Animal Envenomation and Studies
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Hormonal and reproductive studies
- Pregnancy and preeclampsia studies
- Atherosclerosis and Cardiovascular Diseases
- Adrenal Hormones and Disorders
- Diphtheria, Corynebacterium, and Tetanus
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lipoproteins and Cardiovascular Health
Oniris
2014-2024
PhysioPathologie des Adaptations Nutritionnelles
2018-2022
Inserm
2002-2021
Nantes Université
2021
Centre National de la Recherche Scientifique
2021
Institut du Thorax
2021
Université Nantes Angers Le Mans
2010-2018
École Normale Supérieure - PSL
2009
École Nationale Vétérinaire de Toulouse
2003-2008
Pompe disease is a lysosomal storage disorder caused by acid-α-glucosidase (GAA) deficiency, leading to glycogen storage. The manifests as fatal cardiomyopathy in infantile form. Enzyme replacement therapy (ERT) has recently prolonged the lifespan of these patients, revealing new natural history. neurologic phenotype and persistence selective muscular weakness some patients could be attributed central nervous system (CNS) uncorrected ERT. GAA-KO 6neo/6neo mice were treated with single...
The metabolic syndrome (MetS) has become a global public health burden due to its link cardiovascular disease and diabetes mellitus. present study was designed characterize the disturbances, as well changes in gut microbiota associated with high-fructose high-fat diet (HFFD)-induced MetS Watanabe heritable hyperlipidemic (WHHL) rabbits. Twenty-one rabbits were assigned control (n = 9) HFFD 12) groups, receiving chow HFFD, respectively. During 12-weeks protocol, morphological parameters...
1 In hypertension, a decrease of the vascular beta-adrenergic relaxation has been described. However, specific involvement each beta-adrenoceptor (beta-AR) subtype, in particular low-affinity state beta1-AR, not yet evaluated. We investigated whether beta1-AR-induced was impaired Spontaneously Hypertensive Rats (SHR). 2 The relaxant responses to CGP 12177 and cyanopindolol, beta1-AR agonists (with beta1-/beta2-AR antagonistic partial beta3-AR agonistic properties) were evaluated on thoracic...
Viperidae snakes venoms represent a source of efficient bioactive components that have already led to the development several new drugs. In this work, we analyzed protein content Montivipera bornmuelleri crude venom using LC-ESI-MS, sephadex G-75 gel filtration and SDS-PAGE demonstrated presence proteins with molecular masses corresponding metalloprotease III, serine-protease PLA2 in three fractions collected after filtration. Equally, examined antimicrobial effect showed an important...
Obesity is a global public health issue linked to various comorbidities in both humans and animals. This study investigated the effects of vitamin D (VD) omega-3 fatty acids (ω3FA) on obesity, gut dysbiosis, metabolic alterations Wistar rats. After 13 weeks standard (S) or High-Fat, High-Sugar (HFHS) diet, rats received VD, ω3FA, combination (VD/ω3), control (C) for another weeks. The HFHS diet led increased weight gain, abdominal circumference, glucose intolerance, insulin resistance,...
Abstract Objectives In experimental pharmacology, drug effect studies currently establish and analyse cumulative concentration–response curves (CCRC) under repeated measurements designs. Usually the CCRC parameters are estimated using Hill's function in a nonlinear regression for independent data. The two-way analysis of variance is generally used to identify statistical difference between responses two treatments but that does not take into account nonlinearity model heteroscedasticity...
AbstractPhospholipase A2 (PLA2), a common toxic component of snake venom, is responsible for wide spectrum biological and toxicological effects including bactericidal, anticoagulant, hemolytic, as well neurotoxic cardiotoxicity activities. In the present work, phospholipase named (Mb-PLA2) was isolated from venom Montivipera bornmuelleri Lebanese snake, by two-step procedure consisting gel filtration chromatography on Biogel P60 reverse phase high pressure liquid (RP-HPLC) Restek Ultra II...
Abstract Objective —To investigate the functional expression of β3-adrenoceptors (β 3 -ARs) in equine digital veins (EDVs) and to examine whether β -AR relaxation was altered EDVs incubated with endotoxin. Sample Population —Forelimbs obtained from 30 horses. Procedure were horses an abattoir. Equine carefully removed distal portions forelimbs. Rings dissected mounted 5-mL organ baths record isometric tension presence various agonists (SR 58611A, ZD 2079, ZM 215001). Results —In intact EDVs,...
Vaccination is an important mainstay of biosecurity and disease prevention in livestock farming. failures represent economic burden for the farmer. Polyphenol supplementation, known its antioxidant properties, could help reduce oxidative damage improve success vaccination. We evaluated effect a rumen-protected grape extract (RPGE) supplementation around vaccination on immune response young ruminants. 22 female cattle (aged 6 to 8 months), born same dairy farm, were randomly divided into 2...
Much evidence indicates that metabolic syndrome is strongly correlated with a decrease in nitric oxide and an increase oxidative stress leading to cardiovascular alterations. In recent years, gut microbiota has emerged as new contributor the establishment associated diseases, but underlying mechanisms remain unclear. We hypothesized positive modulation of cyclic guanosine monophosphate (cGMP) pathway, through phosphodiesterase type 5 (PDE5) inhibition could prevent alterations dysbiosis may...
Abstract Objective —To investigate the role of superoxide anions in lipopolysaccharide (LPS)-induced impairment β-adrenoceptor-mediated equine digital vein (EDV) vasodilation. Sample Population —EDVs isolated from forelimbs 24 healthy adult horses. Procedures —Endothelium-intact or endothelium-denuded EDV rings were incubated with without LPS (10 μg/mL) Escherichia coli (O55:B5) for 4 hours. Cumulative concentration-relaxation curves resulting administration isoprenaline, a nonselective...
Circulating autoantibodies directed against the 2nd extracellular loop (EL-2) of β(1)-adrenoceptors (β(1)-AABs) have been detected in serum patients with various cardiovascular pathologies. β(1)-AABs induce agonistic, positive inotropic effects via (β(1)ARs). In mammalian heart, β(1)-AR can exist 2 distinct activated configurations (the so-called high- and low-affinity states). The aim present study was to investigate whether action β(1)-AAB is dependent on affinity state β(1)AR isolated...
Dysfunction of venous valves can lead to hemodynamic disorders causing stasis, which would favour the occurrence equine laminitis. However, very few studies have investigated in horse digit. The purpose this study was compare valvular density between thoracic and pelvic limbs relationship veins their location, diameter wall thickness. After dissection, calculated based on number counted principal 7 from horses. Our results showed that higher limbs, probably reflects adaptation consequences...
In porcine coronary arteries (PCAs), celiprolol, a selective β(1)-adrenoceptors antagonist, induces vasodilatation by an endothelium- and nitric oxide (NO)-dependent pathway. However, the mechanisms of that vascular effect have not been precisely established. β(3)-Adrenoceptors shown to be involved in relaxation per se various beds, including vessels. Thus, we evaluated (i) presence β(3)-adrenoceptors PCA (ii) their role celiprolol-induced vasodilatation. rings were placed organ baths...