A5013549367- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Healthcare and Venom Research
- Bee Products Chemical Analysis
- Insect and Pesticide Research
- Long-Term Effects of COVID-19
- CAR-T cell therapy research
- Toxin Mechanisms and Immunotoxins
- COVID-19 Clinical Research Studies
- Pesticide Residue Analysis and Safety
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Marine Invertebrate Physiology and Ecology
- Virus-based gene therapy research
- Cardiac electrophysiology and arrhythmias
- SARS-CoV-2 and COVID-19 Research
- Probiotics and Fermented Foods
- Toxic Organic Pollutants Impact
- Rabies epidemiology and control
- Neuroscience and Neuropharmacology Research
- Environmental Toxicology and Ecotoxicology
- Viral Infectious Diseases and Gene Expression in Insects
Lebanese University
2016-2025
Centre National de la Recherche Scientifique
1999-2019
Institut des Sciences Chimiques de Rennes
2019
Université de Rennes
2019
Inserm
2019
Université d'Angers
2019
University of Macau
2019
Kyung Hee University
2019
Belarusian State University
2017
Middle East University
2015
Abstract Chronic myeloid leukemia (CML) is a chronic disease resulting in cell expansion through expression of the BCR-ABL1 fusion transcript. Tyrosine kinase inhibitors (TKI) have significantly increased survival patients with CML, and deep responders may consider stopping treatment. However, more than 50% relapse restart TKI, subsequently suffering unknown toxicity. Because CML model immune system–sensitive disease, we hypothesize that chimeric antigen receptor (CAR) T cells targeting IL1...
Bee venom is a mixture of several components with proven therapeutic benefits, among which are anti-inflammatory, analgesic, and various cardiovascular conditions. In this work, we analyzed for the first time proteomic content biological properties crude from Apis mellifera syriaca, honeybee Middle East region. Using high-performance liquid chromatography-tandem mass spectrometry, evidence contains phospholipase A2, hyaluronidase, mast cell-degranulating peptide, adolapin, apamin, melittin....
Apamin-sensitive small conductance calcium-activated potassium channels (SKCa1–3) mediate the slow afterhyperpolarization in neurons, but molecular identity of channel has not been defined because lack specific inhibitors. Here we describe structure-based design a selective inhibitor SKCa2. Leiurotoxin I (Lei) and PO5, peptide toxins that share R<i>X</i>CQ motif, potently blocked human SKCa2 SKCa3 SKCa1, whereas maurotoxin, Pi1, Tsκ, PO1 were ineffective. Lei these more than PO5 presence...
Colon carcinogenesis is ranked second globally among human diseases after cardiovascular failures. Bee venom (BV) has been shown to possess in vitro anticancer effects against several types of cancer cells. The two main biopeptides Apis mellifera BV, namely, melittin (MEL) and phospholipase A2 (PLA2), are suspected be the biomolecules responsible for activity. present work aims evaluate cytotoxic effect A. on colon carcinoma cells (HCT116), assess synergistic MEL PLA2 these After analyzing,...
The overlap between mechanical engineering and medicine is expanding more over the years. Engineers are now using their expertise to design create functional biomaterials continually collaborating with physicians improve patient health. In this review, we explore state of scientific knowledge in areas biomaterials, biomechanics, nanomechanics, computational fluid dynamics (CFD) relation pharmaceutical medical industry. Focusing on current research breakthroughs, provide an overview how these...
Hyperalgesia is a condition marked by an abnormal increase in pain sensitivity, often occurring response to tissue injury, inflammation, or prolonged exposure certain medications. Inflammatory mediators, such as cytokines IL-1β, IL-6, and TNF-α, play central role this process, amplifying perception. Developing effective treatments that address the underlying mechanisms of hyperalgesia active field research. Apis mellifera syriaca venom demonstrated potential immunomodulatory activity...
Background/Objective: Colon cancer poses a significant health burden, with current treatments often associated severe side effects and limited effectiveness for some patients. Natural products are gaining interest as adjuvant therapies, potentially reducing improving responses to conventional treatments. We previously highlighted the potent antineoplastic of organic extracts derived from Lebanese red algae Jania rubens. This study, investigated anticancer activities polysaccharide, protein,...
The French Society of Toxinology (SFET) held its 30th Annual Meeting (RT30) on 2-3 December 2024 at Hôtel Le Saint Paul in Nice, France, the beautiful Riviera. It was first time that event organized outside Paris. meeting brought together 74 participants and focused main theme, "Unlocking Deep Secrets Toxins", which delved into cutting-edge research field animal venoms toxins from animal, plant, fungal, algal, mold bacterial sources. emphasized dynamic ever-evolving nature toxins, often...
Introduction: Combining multiple natural extracts may provide an additive and/or synergistic effect, increasing the anti-cancer potential of formulation while aiding in search for targeted chemical compounds cancer treatment. Method: Here, we confirmed individual vitro anti-proliferation effect Apis mellifera syriaca bee venom (BV) and Jania rubens red algae polysaccharide extract (PE) on HCT-116 HT-29 colon cell lines explored these two extracts, aiming to develop a new mixture with...
Maurocalcine is a novel toxin isolated from the venom of chactid scorpion Scorpio maurus palmatus. It 33‐mer basic peptide cross‐linked by three disulfide bridges, which shares 82% sequence identity with imperatoxin A, Pandinus imperator . peculiar in terms structural properties since it does not possess any consensus motif reported so far other toxins. Due to its low concentration (0.5% proteins), maurocalcine was chemically synthesized means an optimized solid‐phase method, and purified...