A5055454318- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Ion channel regulation and function
- Viral Infectious Diseases and Gene Expression in Insects
- Nitric Oxide and Endothelin Effects
- Nicotinic Acetylcholine Receptors Study
- Chemical synthesis and alkaloids
- Bee Products Chemical Analysis
- Ion Transport and Channel Regulation
- Alkaloids: synthesis and pharmacology
- Insect and Pesticide Research
- Renin-Angiotensin System Studies
- Bioactive Natural Diterpenoids Research
- Marine Invertebrate Physiology and Ecology
- Botanical Research and Chemistry
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Berberine and alkaloids research
- Toxin Mechanisms and Immunotoxins
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
Centre National de la Recherche Scientifique
2019-2024
Lebanese University
2019-2024
Université d'Angers
2019-2024
Inserm
2019-2024
Institut Pasteur
2023
Université Paris Cité
2023
Institut du Thorax
2022
Nantes Université
2022
Centre Hospitalier Universitaire d'Angers
2021
Kyung Hee University
2019
Bee venom is a mixture of several components with proven therapeutic benefits, among which are anti-inflammatory, analgesic, and various cardiovascular conditions. In this work, we analyzed for the first time proteomic content biological properties crude from Apis mellifera syriaca, honeybee Middle East region. Using high-performance liquid chromatography-tandem mass spectrometry, evidence contains phospholipase A2, hyaluronidase, mast cell-degranulating peptide, adolapin, apamin, melittin....
Voltage-gated Na+ (NaV) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting search novel NaV channel ligands. With objective discovering new blockers ligands, we screened an In-House vegetal alkaloid library using fluorescence cell-based assays. We 62 isoquinoline alkaloids (IA) their ability to decrease FRET signal voltage sensor probes (VSP), which were induced by activation with batrachotoxin (BTX) in GH3b6 cells. This led...
The vegetal alkaloid toxin veratridine (VTD) is a selective voltage-gated Na+ (NaV) channel activator, widely used as pharmacological tool in vascular physiology. We have previously shown that NaV channels, expressed arteries, contribute to tone mouse mesenteric arteries (MAs). Here, we aimed better characterize the mechanisms of action VTD using cecocolic (CAs), model resistance artery. Using wire myography, found induced vasorelaxation CAs. This VTD-induced relaxation was insensitive...
Summary Nicotine, by stimulating ventral tegmental area (VTA) dopaminergic neurons, has a rewarding effect that drives tobacco consumption. In turn, the interpeduncular nucleus (IPN) is thought to become activated at high nicotine doses restrict drug intake. However, dynamics of IPN response and its impact on remain unknown. To address this issue, we have developed genetically-modified mouse model, in which “suicide” antagonist nicotinic acetylcholine receptors (nAChRs) selectively attaches...
The isoquinoline alkaloids (IAs) represent a large and diverse subfamily of phytochemicals in terms structures pharmacological activities, including ion channel inhibition. Several IAs, such as liriodenine (an oxoaporphine) curine (a bisbenzylisoquinoline (BBIQ), inhibit the L-type voltage-gated Ca2+ channels (LTCC). In this study, we aimed to search for new blockers LTCC, which are therapeutic targets neurological cardiovascular diseases. We set up screening assay using rat pituitary GH3b6...