A5022455707- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Cardiovascular Effects of Exercise
- Eating Disorders and Behaviors
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Connective Tissue Growth Factor Research
- Delphi Technique in Research
- Peroxisome Proliferator-Activated Receptors
- Healthcare professionals’ stress and burnout
- Pharmacology and Obesity Treatment
- Telemedicine and Telehealth Implementation
- Neuropeptides and Animal Physiology
- Healthcare Systems and Technology
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 and Mental Health
- Insect and Pesticide Research
- Cardiac Arrest and Resuscitation
- COVID-19 and healthcare impacts
Institute of Clinical and Experimental Medicine
2013-2024
University Hospital Coventry
2019-2021
Worcestershire Acute Hospitals NHS Trust
2019-2021
Worcestershire Royal Hospital
2018-2020
Coventry University
2019
Hospital of the University of Pennsylvania
2013-2014
Institute of Endocrinology
2006-2008
Background— Catheter ablation has become an established treatment modality for a broad spectrum of ventricular tachycardias (VTs). We analyzed incidence and predictors major complications VT procedures in high-volume expert center. Methods Results— evaluated 548 consecutive patients who underwent 722 procedures, 473 (65.5%) structural heart disease the period 2006 to 2012. There were 45 (6.2%) observed 44 patients. Access site vascular most frequent (3.6%). Three (0.4%) had cardiac...
Catheter ablation (CA) for atrial fibrillation (AF) is a complex procedure that associated with higher risk of complications. This study aimed at exploring the complication rate and corresponding factors in high-volume centre routine use intracardiac echocardiography (ICE). In total 1192 consecutive AF procedures (100% ICE-guided; 96.4% 3D-navigated; point-by-point radiofrequency open-irrigated tip catheter; 22.4% robotic navigation; 25.4% repeated ablation) were performed 959 patients (aged...
Complications of catheter ablation for atrial fibrillation (AF) are frequently related to vascular access. We hypothesized that ultrasound-guided (USG) venipuncture may facilitate the procedure and reduce complication rates.We conducted a multicentre, randomized trial in patients undergoing AF on uninterrupted anticoagulation therapy. The study enrolled consecutive 320 (age: 63 ± 8 years; male: 62%) were USG or conventional 1:1 fashion. It was prematurely terminated due substantially...
To determine whether ventricular tachycardia (VT) recurrences in arrhythmogenic RV cardiomyopathy (ARVC) and nonischemic (NICM) are related to incomplete ablation or disease progression.ARVC NICM patients with two substrate maps of the same diseased ventricle an interprocedural delay ≥12 months were included. Disease progression was defined as ≥1 factor: scar area (PROG, +5%), remodeling (dilatation [+25 mL] decreased ejection fraction [-5%EF]). Incomplete index VT recurrence previously...
Abstract Background Substrate mapping has highlighted the importance of targeting diastolic conduction channels and late potentials during ventricular tachycardia (VT) ablation. State-of-the-art multipolar catheters have enhanced capabilities. The purpose this study was to investigate whether long-term outcomes were improved with use a HD Grid catheter combining complementary strategies in patients structural heart disease VT. Methods Consecutive underwent VT ablation assigned either Grid,...
Patients with structural heart disease (SHD) undergoing catheter ablation (CA) for ventricular tachycardia (VT) are at considerable risk of periprocedural complications, including acute haemodynamic decompensation (AHD). The PAINESD score was proposed to predict the AHD. goal this study validate using retrospective analysis data from a large-volume centre.
Catheter ablation of ventricular tachycardia (VT) in patients with structural heart disease (SHD) is effective prevention arrhythmia recurrences. However, endocardial may be challenging the presence organized left (LV) endocavitary thrombus. Our goal was to analyze results VT identified old thrombus.We reviewed clinical and procedural data 344 consecutive who underwent for SHD. Old thrombus four by preprocedural transthoracic echocardiography (TTE) more intracardiac (ICE). All together, case...
In patients with severe neurally mediated syncope (NMS), radiofrequency catheter ablation (RFA) of ganglionic plexi (GP) has been proposed as a new therapeutic approach. Cardio-inhibitory response during NMS is usually related to the sinoatrial (SA) and less frequently atrioventricular (AV) node. Differential effect GP on SA AV node poorly understood. We report case 35-year-old female frequent symptomatic episodes advanced block treated by anatomically guided RFA at empirical sites GPs....
Abstract Introduction Frequent ventricular premature complexes (VPCs) may cause symptoms and/or lead to deterioration of LV systolic function. Although frequent VPCs be abolished by catheter ablation, it challenging in case their origin from the papillary muscles (PMs). Our collaborative study aimed analyze detail site and outcome ablation. Methods Consecutive 34 patients (males: 68%; aged 62 ± 12 years; ejection fraction: 50 9%) undergoing ablation originating PMs were included. All...
To investigate predictors of long-term outcomes after catheter ablation (CA) for ventricular tachycardia (VT) and the impact electrical storm (ES) prior to index procedures.We studied consecutive patients with structural heart disease VT (n = 328; age: 63±12 years; 88% males; 72% ischaemic cardiomyopathy; LVEF: 32±12%) who had undergone CA. According presenting arrhythmia at baseline, they were divided into ES 93, 28%) non-ES groups. Clinical all-cause mortality investigated a clinically...
Catheter ablation for complex left-atrial arrhythmia is increasing worldwide with many centres admitting patients overnight. Same-day procedures using conscious sedation carry significant benefits to patients/healthcare providers but data are limited. We evaluated the safety and cost-effectiveness of same-day ablation.Multi-centre retrospective cohort study all consecutive elective performed between January 2011 December 2019. Data were collected on planned discharge versus overnight stay,...
Neuromedin beta (NMB) is a member of the bombesin-like peptide family expressed in brain, gastrointestinal tract, pancreas, adrenals and adipose tissue. The aim our study was to compare frequency P73T polymorphism overweight obese patients (37 men: age 50.6+/-11.7 years, BMI 41.1+/-7.8 kg/m(2); 255 women: 49.0+/-11.9 37.9+/-6.8 kg/m(2)) with that healthy normal weight subjects (51 28.2+/-7.1 22.3+/-2.0 104 29.1+/-9.1 21.5+/-1.9 investigate polymorphism's influence on anthropometric,...
Atrial fibrosis is considered as the basis in development of long-standing atrial fibrillation (AF). However, advanced heart failure (HF), independent role for AF less clear since HF itself leads to scarring. Our study aimed differentiate patients with from without a population consisting HF. Myocardial samples right and left ventricular wall were obtained during transplantation explanted hearts 21 male Long-standing was present 10 them remaining 11 served sinus rhythm controls....
Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinical benefit and safety remain still less defined this population. A retrospective analysis the results AF a large volume center focused on comparison with rest patient cohort was conducted study.Consecutive who underwent between January 2001 December 2016 were analysed. total population 3197 dichotomized by age 70 years (394 vs. 2803 younger subjects). Patients followed...
Radiofrequency catheter ablation has become the treatment of choice for atrial fibrillation (AF) that does not respond to antiarrhythmic drug therapy. During procedure, fluoroscopy imaging is still considered essential visualise catheters in real-time. However, radiation often ignored by physicians since it invisible and long-term risks are underestimated. In this respect, must be emphasised exposure various potentially harmful effects, such as acute skin injury, malignancies genetic...
VT Ablation in Patients With Preserved LV Function Introduction with coronary artery disease (CAD), relatively preserved left ventricular ejection fraction (LVEF), and hemodynamically tolerated tachycardia (VT) may benefit from catheter ablation as the first‐line treatment. Our aim was to analyze long‐term results of this population. Methods Results Thirty‐one patients (1 woman, mean age 67 ± 10 years) CAD, VT, LVEF ≥40% underwent treatment arrhythmia. Catheter performed order abolish all...
In Vitro Evaluation of Ice‐Cold Saline Irrigation Introduction Irrigated radiofrequency (RF) catheters allow tissue‐electrode interface cooling, decreasing thrombus risk while enabling higher RF power delivery. The impact irrigation with ice‐cold saline (ICS) instead conventional ambient‐temperature (ATS) on lesion formation is unknown. Methods and Results We performed 120 ablations in vitro porcine left ventricles, using ICS (<5 °C) or ATS (21 irrigation. For irrigation, the circuit was...