A5103205972- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Central Venous Catheters and Hemodialysis
- Cardiovascular and Diving-Related Complications
- Vascular Procedures and Complications
- Vascular anomalies and interventions
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Acute Ischemic Stroke Management
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Viral Infections and Immunology Research
- Lysosomal Storage Disorders Research
Czech University of Life Sciences Prague
2025
University Hospital Olomouc
2015-2024
Palacký University Olomouc
2012-2024
University of South Bohemia in České Budějovice
2022-2023
Krajská Zdravotní
2021-2023
University Hospital Ostrava
2021-2023
University of British Columbia
2022-2023
University of Northern British Columbia
2022
University Hospital Plzen
2021
Vancouver General Hospital
2020
Abstract Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), which pre-clinical and early-stage clinical data are suggestive some degree preferentiality to myocardial tissue without damage adjacent structures. Here in MANIFEST-17K study we assessed safety PFA by studying post-approval use this modality. Of 116 centers performing with a pentaspline catheter, were received from 106 (91.4% participation) regarding 17,642 patients undergoing (mean...
Abstract Aims Data on the hybrid atrial fibrillation (AF) treatment are lacking in patients with structural heart disease undergoing concomitant CryoMaze procedures. The aim was to assess whether timely pre-emptive catheter ablation would achieve higher freedom from AF or tachycardia (AT) and be associated better clinical outcomes than surgical alone. Methods results trial investigated non-paroxysmal coronary artery bypass grafting and/or valve repair/replacement mandatory procedure who were...
Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration most active components in species or genotypes, new formulation techniques development. In recent years, there has been a growing interest use nanomaterials because significant pharmacology applications as substance carriers. Applying nanoparticles...
Ischaemic stroke, especially in the younger population, is an important cause of morbidity and mortality. When compared with older underlying aetiology stroke young includes higher rates cardioembolic disease congenital heart anomalies. Paradoxical embolism may be ischaemic cerebral events, which has to ruled out patients no other evident aetiology. A persistent left superior vena cava (PLSVC) that drains into atrium a very rare anomaly occurring postnatal life embolic events such as...
Abstract Introduction Frequent ventricular premature complexes (VPCs) may cause symptoms and/or lead to deterioration of LV systolic function. Although frequent VPCs be abolished by catheter ablation, it challenging in case their origin from the papillary muscles (PMs). Our collaborative study aimed analyze detail site and outcome ablation. Methods Consecutive 34 patients (males: 68%; aged 62 ± 12 years; ejection fraction: 50 9%) undergoing ablation originating PMs were included. All...
Atrial fibrillation is known very frequent cause of ischemic stroke. Undetected paroxysmal atrial (PAF) thus often considered a possible cryptogenic stroke (CIS). The aim this prospective study was to detect PAF using ECG Holter monitoring and determinate whether prolongation the 3 weeks would increase detection rates in young CIS patients ≤ 50 years.The set consisted IS years enrolled HISTORY (Heart Ischemic STrOke Relationship studY) (NCT01541163). defined according TOAST criteria...
Úvod: Hrudní pás umožňuje pořídit 1svodový EKG záznam. Získaná data byla validována pro měření srdeční frekvence a rovněž i detekci fibrilace síní díky srovnání s krátkými záznamy z holterovského u selektovaných pacientů. Zatím ale nebyla ověřena možnost vyhodnocení dlouhých záznamů neselektovaných kardiologických pacientů se širokým spektrem srdečních chorob. Metodologie výsledky: Do studie bylo zařazeno 54 hospitalizovaných 53 ambulantních zdravých kontrol (n = 161 celkově). U všech...
<b><i>Background:</i></b> Undetected atrial fibrillation (AF) is often suspected as the possible cause in patients with cryptogenic ischemic stroke (IS), especially elderly population. In young IS patients, prevalence of AF, particularly paroxysmal form, remains still not enough established. Our aim was to assess presence AF using a long-term electrocardiography (ECG) Holter monitoring. <b><i>Methods:</i></b> The study set consisted acute ≤50...
A substantial proportion of arteriovenous fistulas fail to function adequately for hemodialysis. Existing studies on fistula failure prediction assess patency rather than the more clinically relevant outcome function. We hypothesized that preoperative demographic and ultrasound characteristics, postoperative assessment by an experienced vascular access nurse would predict which will not hemodialysis.Prospective cohort study chronic kidney disease patients at a tertiary care center in...
V tomto přehledovém článku shrnujeme již zavedené i nové elektroanatomické mapovací systémy a technologie pro katetrizační ablaci arytmií, zejména fibrilace síni. posledních letech počet katetrizačních ablací exponenciálně roste díky technologickým pokrokům umožňujícím komplexní katétrové ablace. Kvalita současných systémů mapování je dostatečně vysoká jak standardní ablace, jako izolace plicních žil, tak hodnocení komplexních arytmií. Nadále jsou vyvíjeny nástroje s cílem usnadnit...
Atrial fibrillation (AF), typical atrial flutter (AFL), and other tachycardias (ATs) are common in patients with pulmonary hypertension. Frequently, several supraventricular arrhythmias successively observed individual patients. We investigated the hypothesis of whether more extensive radiofrequency catheter ablation bi-atrial arrhythmogenic substrate instead clinical arrhythmia alone results superior outcomes arterial hypertension (PH) arrhythmias.Patients combined post- pre-capillary or...
Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Surgical CryoMaze has been shown to be an effective treatment several trials, but success rates have varied considerably, between 47-95%. The sequential hybrid approach, combining surgical followed by radiofrequency catheter ablation, can achieve high freedom from atrial arrhythmias. However, concomitant treatment, data comparing the approach alone lacking.The SurHyb study was designed...
Abstract Aims A retrospective nationwide observational analysis of diagnoses, procedures, and treatment reported to the Czech National Registry Reimbursed Health Services between 2012 2018. Methods results Prevalence heart failure (HF) patients increased from 176 496 (1679.4 per 100 000 population) in 285 745 (2689.0 2018 (mean age 74.4 ± 12.8 years). In last years, a stable incidence HF was observed (544 population 2016 vs. 551 2018; P = 0.310). Mortality rate decreased 20.55% 15.89% The...
Analysis of mortality from the national health registries and data a specific central registry dealing with implantation pacemakers (REPACE) in Czech patients.Retrospective observational analysis pacemakers' all patients [n = 82,791; 47,070 (56.9%) men, 75.9 ± 10.4 years old] between 2010 2021. Almost 114,000 were implanted 2021, which 27.9% single-chamber, 67.4% dual-chamber 4.6% biventricular. The annual number implantations has been steadily increasing 6% decline 2020 increased reductions...
Leadless pacemakers (PMs) were recently introduced to address the complication rate of standard PMs with transvenous leads.A 34-year old male a history intravenous substance abuse and chronic type C hepatitis developed complete atrioventricular block after cardiac surgery for infective endocarditis. Repeatedly, endo- epi-cardially implanted had be explanted due infection. A leadless MICRA pacemaker was successfully dislocation into pulmonary artery several days implantation. The PM retrieved...
Catheter ablation of paroxysmal atrial fibrillation (AF) can be performed under general anesthesia or conscious sedation. The influence type anesthesiology care on procedural characteristics and outcome in patients whom intracardiac echocardiography (ICE) elimination adenosine-mediated dormant conduction (DC) is used not entirely known.150 with AF were randomized to point-by-point radiofrequency catheter isolation pulmonary veins (PVI) (n=77) sedation (n=73). Adenosine-mediated was...
The aim was to compare the speckle tracking echocardiography (STE) derived systolic longitudinal strain (SL(Smax)) with rest single photon emission computed tomography (SPECT) perfusion imaging (Q(REST)), and define optimal cut-offs for SL(Smax) discriminate transmural scar on contrast-enhanced magnetic resonance (ceCMR).In 100 patients chronic ischemic left ventricular (LV) dysfunction, myocardial viability assessed using STE SPECT predict LV segmental relative extent of delayed enhancement...
To assess the acute side-effects of right ventricular (RV) stimulation applied in apex and mid-septum, order to establish optimal lead location clinical practice.During pacemaker implantation, was temporarily fixed then moved mid-septum. In both positions, surface endocardial electrograms transvalvular impedance (32 cases), left (LV) pressure (23), transthoracic echocardiography (10) were acquired with intrinsic activity VDD pacing.A larger increase QRS duration noticed apical than septal...
Terapie akutní fáze ischemické cévní mozkové příhody je zaměřena na omezení rozsahu poškození mozku co možná nejčasněji podanou reperfuzní léčbou a následnou sekundárně preventivní farmakoterapií. Klíčovým faktorem ve stanovení správné strategie objasnění etiologie zejména s ohledem fakt, že riziko recidivy nejvyšší během prvního týdne od příhody. Vyloučení potenciálních kardiovaskulárních zdrojů různým embolizačním potenciálem zásadním krokem v rámci sekundární prevence Jícnová...
Background: Rupture of a papillary muscle is an infrequent but often fatal mechanical complication acute myocardial infarction. Aim: The aim this paper to present case report 65-year old women with severe mitral regurgitation cardiogenic shock caused by two-step complete anterior rupture during transthoracic echocardiography was obtained at the bedside and showed posterior valve prolapse regurgitation. During examination patient developed pulmonary oedema consequent shock. Transthoracic then...
Aim: The aim of this study was to assess accuracy echocardiography in the measurement left ventricular ejection fraction (LVEF), enddiastolic volume (EDV) and endsystolic (ESV) compared with gated SPECT. Methods: A total 70 patients systolic dysfunction were enrolled study. Median time interval between SPECT 1 hour. Results: Echocardiography good agreement for quantification LVEF by using Simpson's method triplane (r=0.88, p<0.001), biplane (r=0.83, p<0.001) monoplane apical four chamber...
Abstract Aims The aim of this study is to analyse the prevalence, epidemiology, and anticoagulation prevention stroke or transient ischaemic attack (TIA) in Czech patients with atrial fibrillation (AF). Methods results Retrospective observational analysis diagnoses, procedures, treatment reported National Registry Reimbursed Healthcare Services between 2015 2018. Prevalence AF 2018 was 4.3% population prevalence stroke/TIA 22.3% annual incidence 181.62 cases per 100 000 inhabitants. In 2018,...
Sub-analysis of a retrospective nation-wide observational analysis heart failure (HF) epidemiology reported to the Czech National Registry Reimbursed Health Services between 2012 and 2018 aimed at beta-blockers (BBs) utilization.The were generally used in 81.8% all patients treated for HF (n=52 140); 2013 (n=53 058); 83.1% 2014 (n=56 221); 82.1% 2015 (n=57 421); 83.3% 2016 (n=59 187); 82.2% 2017 (60 058) 81.4% (n=60 966). In 2018, majority prescribed metoprolol (22 974; 30.7%) bisoprolol (21...