A5038350906- Gut microbiota and health
- Inflammatory Bowel Disease
- Silymarin and Mushroom Poisoning
- Phytochemicals and Antioxidant Activities
- Clostridium difficile and Clostridium perfringens research
- Educational and Social Studies
- Herbal Medicine Research Studies
- Philosophy, Sociology, Political Theory
- Allelopathy and phytotoxic interactions
- Child Therapy and Development
- Pharmacological Effects of Natural Compounds
- Medical and Biological Ozone Research
- Fermentation and Sensory Analysis
- Horticultural and Viticultural Research
- Psychoanalysis and Psychopathology Research
- Insect and Pesticide Research
- Diet and metabolism studies
- Italian Literature and Culture
- Phytochemistry and Bioactivity Studies
- Metabolomics and Mass Spectrometry Studies
- Bee Products Chemical Analysis
- Cholinesterase and Neurodegenerative Diseases
- Selenium in Biological Systems
- Heavy Metals in Plants
- Pharmaceutical and Antibiotic Environmental Impacts
Czech University of Life Sciences Prague
2020-2025
University of Pisa
2021
Within the group of higher fungi, edible medicinal mushrooms have a long history being used as food and in folk medicine. These species contain biologically active substances with many potential beneficial effects on human health. The Pleurotus genus is representative because ostreatus one most commonly cultivated culinary mushrooms. In our study, we focused lesser-known measured their antioxidant anti-inflammatory activity. We prepared extracts analyzed them using HPLC-HRMS, GC-MS, 1H-NMR....
Predicting response to exclusive enteral nutrition (EEN) in active Crohn's disease (CD) could lead therapy personalization and pretreatment optimization.
Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration most active components in species or genotypes, new formulation techniques development. In recent years, there has been a growing interest use nanomaterials because significant pharmacology applications as substance carriers. Applying nanoparticles...
Cardiometabolic disease is the leading cause of death in zoo apes; yet its etiology remains unknown. Here, we investigated compositional and functional microbial markers fecal samples from 57 gorillas across U.S. zoos, 20 which are diagnosed with cardiovascular disease, contrast 17 individuals European zoos 19 wild Central Africa. Results show that zoo-housed exhibit most diverse gut microbiomes increased protein carbohydrate fermentation, at expense metabolic traits associated plant...
Fig trees (Ficus carica L.) are commonly grown in the Mediterranean area, where salinity is an increasing problem coastal areas. Young, fruiting plants of cv. Dottato were subjected to moderate salt stress (100 mM NaCl added irrigation water) for 48 days before fruit sampling. To clarify effect stress, we investigated changes transcription main sugar metabolism-related genes involved synthesis, accumulation and transport soluble carbohydrates ripe fruits by quantitative real-time PCR as well...
Recently, neglected and underutilized species (NUS) have deservedly come to the forefront of scientific interest because they can contribute human nutrition, due content bio-active substances such as antioxidants. Despite great diversity rich tradition in use Philippine NUS, nutritional properties many edible plants remain unexplored. The main objective this study was evaluate various parts eleven NUS fruits vegetables traditionally consumed Philippines, namely Allaeanthus luzonicus,...
Exclusive enteral nutrition (EEN) is an effective treatment for active Crohn's disease (CD). This study explored the immunostimulatory potential of a cell-free fecal filtrate and related this with changes in microbiota metabolites children CD undertaking EEN.
Abstract Background and Aims Treatment with anti-tumour necrosis factor α antibodies [anti-TNF] changes the dysbiotic faecal bacteriome in Crohn’s disease [CD]. However, it is not known whether these are due to decreasing mucosal inflammatory activity or similar reactions might be observed gut-healthy subjects. Therefore, we explored metabolome upon anti-TNF administration [and therapeutic response] children CD contrasted those anti-TNF-treated juvenile idiopathic arthritis [JIA]. Methods...
Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. Other factors than genetics and intake, however, may play role triggering the disease. The gut internal environment thought to be one of these potential contributing factors, it can influenced throughout life. We examine impact Lactiplantibacillus plantarum HEAL9 Lacticaseibacillus paracasei 8700:2 supplementation on faecal...
Powdery mildew is a common disease affecting the commercial production of gerbera flowers (Gerbera hybrida, Asteraceae). Some varieties show certain degree resistance to it. Our objective was identify biomarkers powdery using an 1H nuclear magnetic resonance spectroscopy and chemometrics approach in complex, fully factorial experiment suggest target for selection breeding. Resistant were found differ from those that susceptible metabolites polyketide pathway, such as gerberin, parasorboside,...
This study investigates how the dietary supplement silymarin, interacts with gut microbiota, a focus on aging populations. Using advanced techniques such as next-generation sequencing, NMR, and LC-MS, we analyzed dual impact of microbiome silymarin metabolism effect microbiome's structure function. The research revealed that significantly alters decreasing short-chain fatty acid production (acetate, butyrate, propionate) glucose utilization. Importantly, unveiled age-related differences in...
This study investigates how the dietary supplement silymarin interacts with gut microbiota, a focus on aging populations. Using advanced techniques such as next-generation sequencing, NMR and LC-MS, we analysed dual impact of microbiome metabolism effect microbiome’s structure function. The research revealed that significantly alters decreasing short-chain fatty acid production (acetate, butyrate, propionate) glucose utilization. Importantly, unveiled age-related differences in catabolism....
Diarrhoea remains an important public health concern, particularly in developing countries, and has become difficult to treat because of antibacterial resistance. The development synergistic antimicrobial agents appears be a promising alternative treatment against diarrhoeic infections. In this study, the combined effect tetracycline together with either nitroxoline, sanguinarine, or zinc pyrithione (representing various classes plant-based compounds) was evaluated vitro selected bacteria...
f silymarin components, particularly isosilybin B, which was associated with higher abundance of Faecalibacterium and Erysipelotrichaceae UCG-003. Conclusion This study provides insights into microbiome functionality in metabolizing dietary flavonolignans, highlighting implications for age-specific nutritional strategies advancing our understanding (poly)phenol metabolism.
f silymarin components, particularly isosilybin B, which was associated with higher abundance of Faecalibacterium and Erysipelotrichaceae UCG-003. Conclusion This study provides insights into microbiome functionality in metabolizing dietary flavonolignans, highlighting implications for age-specific nutritional strategies advancing our understanding (poly)phenol metabolism.
Scope This multi‐omic study investigates the bidirectional interactions between gut microbiota and silymarin metabolism, highlighting differential effects across various age groups. Silymarin, extract from Silybum marianum (milk thistle), is commonly used for its hepatoprotective effects. Methods results An in vitro fermentation colon model was with 20 stool samples obtained healthy donors divided into two A combination of three analytical advanced techniques, namely proton nuclear magnetic...
Intensive agricultural practices impact the health and nutrition of pollinators like honey bees (