A5065388065- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Bioactive natural compounds
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Plant-derived Lignans Synthesis and Bioactivity
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Bioactive Compounds and Antitumor Agents
- X-ray Diffraction in Crystallography
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Traditional Chinese Medicine Analysis
- Phytochemical compounds biological activities
- Morinda citrifolia extract uses
- Plant chemical constituents analysis
- Biochemical Acid Research Studies
- Medicinal Plant Research
- Curcumin's Biomedical Applications
- Medicinal plant effects and applications
- Tea Polyphenols and Effects
Masaryk University
2007-2025
University of Veterinary Sciences Brno
2011-2020
University of Defence
2020
Pharmaceutical Biotechnology (Czechia)
2015-2016
Ankara University
2015
Czech Academy of Sciences, Institute of Experimental Botany
2010
University of Padua
2010
Palacký University Olomouc
2010
Czech University of Life Sciences Prague
2008
University of Antwerp
2007
Abstract Oxidative stress is a fundamental principle in the pathophysiology of many diseases. It occurs when production reactive oxygen species exceeds capacity cell defense system. The hydroxyl radical that commonly formed vivo and can cause serious damage to biomolecules, such as lipids, proteins, nucleic acids. plays role inflammation‐related diseases, like chronic inflammation, neurodegeneration, cancer. To overcome excessive oxidative thus prevent or stop progression diseases connected...
Naturally-occurring mixtures of phytochemicals present in plant foods are proposed to possess tumor-suppressive activities. In this work, we aimed evaluate the antitumor effects Thymus vulgaris L. vivo and vitro mammary carcinoma models. Dried T. (as haulm) was continuously administered at two concentrations 0.1% 1% diet a chemically-induced rat carcinomas model syngeneic 4T1 mouse model. After autopsy, histopathological molecular analyses rodent were performed. addition, evaluations using...
Chromatographic separation of root extracts Morus alba and M. nigra led to the identification 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), H (3), prenylated flavonoids kuwanon E (4), (5), sanggenon (6), cudraflavone B (7), morusinol (8), Diels–Alder adducts soroceal (9), (10). The cytotoxicity their antiphlogistic activity, determined as attenuation secretion TNF-α IL-1β inhibition NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1–10.
Geranyl flavones have been studied as compounds that potentially can be developed anti-inflammatory agents. A series of natural geranylated flavanones was isolated from Paulownia tomentosa fruits, and these were for their activity possible mechanism action. Two new characterized [paulownione C (17) tomentodiplacone O (20)], all the derivatives assayed ability to inhibit cyclooxygenases (COX-1 COX-2) 5-lipoxygenase (5-LOX). The tested showed variable degrees activity, with several them...
Herpes simplex virus (HSV) causes numerous mild-to-serious human diseases, including mucocutaneous herpes infections and life-threatening encephalitis. Moreover, viral lesions can be complicated by inflammation secondary bacterial infections. The development of resistance to antiviral drugs along with the undesirable side effects these are relevant argue for new anti-HSV diverse mechanisms action. Eucalyptus extracts have been used decades combat various infectious diseases. We isolated...
The anthocyanin composition of blue (Triticum aestivum L., cv. Skorpion) and purple wheat aethiopicum JAKUBZ Abyssinskaja arrasajta arrasajta), cultivated in the Czech Republic, prepared whole bread was determined. In wheat, 19 26 anthocyanins, respectively, were tentatively identified by liquid chromatography mass spectrometry. total content anthocyanins determined 9.26 13.23 mgkg−1, respectively. breads baked at 240 180 °C. Some significant differences observed between different baking...
Comprehensive oncology research suggests an important role of phytochemicals or whole plant foods in the modulation signaling pathways associated with anticancer action. The goal this study is to assess activities Cinnamomum zeylanicum L. using rat, mouse, and cell line breast carcinoma models. C. (as bark powder) was administered diet at two concentrations 0.1% (w/w) 1% during experiment chemically induced rat mammary carcinomas a syngeneic 4T1 mouse model. After autopsy, histopathological...
Introduction: Based on extensive data from oncology research, the use of phytochemicals or plant-based nutraceuticals is considered an innovative tool for cancer management. This research aimed to analyze oncostatic properties Salvia officinalis L. [Lamiaceae; Salviae herba] using animal and in vitro models breast carcinoma (BC). Methods: The effects dietary administered S. two concentrations (0.1%/SAL 0.1/and 1%/SAL 1/) were assessed both syngeneic 4T1 mouse chemically induced rat BC....
Metabolites of the edible and medicinal plant Arctium have been shown to possess beneficial activities. The phytochemical profile lappa is well-explored its fruits are known contain mainly lignans, fatty acids, sterols. But other species not thoroughly investigated. Therefore, this study compares metabolic profiles A. lappa, tomentosum, minus. Targeted metabolomics led putative identification 53 metabolites in fruit extracts, majority these being lignans acids. Quantification major showed...
Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4−12) and two roots Morus alba (13 14) were examined for cytotoxicity to selected human cancer cell lines normal fibroblasts. Cytotoxicity was determined in vitro using a calcein AM assay. THP-1 monocytic leukemia line tested erythrosin B staining. The compounds compared with known simple flavanone standards taxifolin (1), naringenin (2), hesperetin (3) standard anticancer drugs olomoucine II, diaziquone,...
Abstract One of the traditional plants that have so many pharmacological effects is chilli fruit (Capsicum sp.) belong to family Solanaceae. Around world, five varieties Capsicum are known, i. e., C. annuum, frutescens, chinense, baccatum, and pubescens. Chilli peppers known for causing sensation heat or burning when consumed. The incited by type amount a group capsaicinoids; alkaloids found only in pepper pods. A widely used measurement SHU (Scoville Heating Unit). This highest dilution...
The effect of dietary administered young barley containing a mixture phytochemicals to female rats for the prevention N-methyl-N-nitrosourea-induced mammary carcinogenesis was evaluated. After carcinogen administration (14 wk), tumors were removed and prepared histopathological immunohistochemical analysis. Moreover, in vitro evaluation possible mechanisms MCF-7 breast cancer cell line performed. Barley (0.3%) demonstrated mild antitumor carcinogenesis, yet 3% did not further improve this...