A5082481355- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Pregnancy and preeclampsia studies
- Gastrointestinal Tumor Research and Treatment
- Blood properties and coagulation
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Birth, Development, and Health
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Nutrition, Genetics, and Disease
- Cervical Cancer and HPV Research
- Prenatal Screening and Diagnostics
- BRCA gene mutations in cancer
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Cancer Risks and Factors
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Blood groups and transfusion
Comenius University Bratislava
2015-2024
Institute of Molecular Biology of the Slovak Academy of Sciences
2013-2022
Cancer Hospital of Chinese Academy of Medical Sciences
2019
Complejo Asistencial Universitario de Palencia
2019
Palacký University Olomouc
2019
Princess Margaret Cancer Centre
2019
Martin University Hospital
2010-2019
University of Chinese Academy of Sciences
2019
Naturally-occurring mixtures of phytochemicals present in plant foods are proposed to possess tumor-suppressive activities. In this work, we aimed evaluate the antitumor effects Thymus vulgaris L. vivo and vitro mammary carcinoma models. Dried T. (as haulm) was continuously administered at two concentrations 0.1% 1% diet a chemically-induced rat carcinomas model syngeneic 4T1 mouse model. After autopsy, histopathological molecular analyses rodent were performed. addition, evaluations using...
Abstract It is supposed that plant functional foods, rich in phytochemicals, may potentially have preventive effects carcinogenesis. In this study, the anticancer of cloves vivo and vitro mammary carcinoma model were assessed. Dried flower buds (CLOs) used at two concentrations 0.1% 1% through diet during 13 weeks after application chemocarcinogen. After autopsy, histopathological immunohistochemical analyses rat carcinomas performed. Moreover, evaluation using MCF‐7 cells was carried out....
Breast cancer is the most common in women worldwide, representing 28.2% of all female malignancies. In addition to genetic changes, epigenetic events, as aberrant DNA methylation and histone modification, are responsible for development
Ovarian cancer is a highly heterogeneous disease and its formation affected by many epidemiological factors. It has typical lack of early signs symptoms, almost 70% ovarian cancers are diagnosed in advanced stages. Robust, non-invasive diagnosis will certainly be beneficial. Herein we analysed the regulatory sequence methylation profiles RASSF1, PTEN, CDH1 PAX1 tumour suppressor genes pyrosequencing healthy, benign malignant tissues, corresponding plasma samples. We recorded statistically...
Congenital fibrinogen disorders are caused by mutations in one of the three genes that affect synthesis, assembly, intracellular processing, stability or secretion fibrinogen. Functional studies mutant Bβ-chains revealed importance individual residues as well three-dimensional structures for assembly and secretion. This study describes two novel homozygous Bβ chain Slovak families with afibrinogenemia hypofibrinogenemia. Peripheral blood samples were collected from all subjects aim...
Breast cancer is one of the most common affecting women and recent research focused on identifying new genetic epigenetic prognostic predictive factors. Glutathione S-transferase P1 (GSTP1) abiotransformation enzyme expressed in normal breast epithelial cells which can be epigenetically inactivated cancer. We have shown, that application nested two-stage methylation-specific PCR (MSP) asuitable method for analysis silenced GSTP1 formalin-fixed paraffin-embedded (FFPE) tissues from patients....
About 50% of melanomas have the BRAFV600E mutation. This mutation is an attractive therapeutic target. The aims our study were to detect mutations within circulating cell-free DNA in plasma ("liquid biopsy") by a droplet digital PCR (ddPCR) method, and investigate how well Breslow-Clark score can be predicted ddPCR.We analyzed 113 patients with malignant melanoma. ddPCR was performed using QX200 system (BIO-RAD®, Hercules). All samples tested duplicate. Besides results liquid biopsy, we...
Cervical cancer is the fourth leading cause of mortality in females worldwide. Infection with high-risk human papillomavirus (HPV) essential but insufficient to cervical cancer, and clearance HPV infection mediated by immune system. The deficit molecules responsible for adhesion may play a role development cancer. E-cadherin encoded cadherin 1 (CDH1) gene, involved cell forming adherens junctions. aim present study was investigate methylation pattern CDH1 promoter identify association...
Gastrointestinal stromal tumors ( GISTs ) are the most common mesenchymal neoplasms of gastrointestinal tract and characterized by presence mutations in tyrosine kinases cKIT KIT PDGFRα PDGFRA ). Mutations identified highly heterogeneous, but some associated with specific clinical features tumor. Samples from 278 GIST patients collected during period 2004–2011 were screened for exons 9, 11, 13, 17 12, 14 18 . Results mutation screening summarized tested possible association parameters...