A5020233630- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Metabolomics and Mass Spectrometry Studies
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Impact on Reproduction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diet and metabolism studies
- Inflammasome and immune disorders
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- interferon and immune responses
- Tryptophan and brain disorders
- Respiratory and Cough-Related Research
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders Research
- Cystic Fibrosis Research Advances
- Cancer Immunotherapy and Biomarkers
- Immune responses and vaccinations
Comenius University Bratislava
2020-2025
Martin University Hospital
2021-2025
Martin University
2024
Medirex Group Academy
2024
The velocity of the COVID-19 pandemic spread and variable severity disease course has forced scientists to search for potential predictors outcome. We examined various immune parameters including markers cells exhaustion activation in 21 patients with hospitalised our hospital during first wave Slovakia. results showed significant progressive lymphopenia depletion lymphocyte subsets (CD3+, CD4+, CD8+ CD19+) correlation severity. Clinical recovery was associated increase CD3+ CD3+CD4+...
Abstract Background The coronavirus disease 2019 (COVID-19) has highly impacted everyday lives and healthcare systems since its spread across the globe. As a result of numerous mutations in viral genome, several genetic variants sub-variants have evolved, they differ various characteristics, such as infectivity, transmissibility, immune response human body. aim this study was to compare cytokine levels plasma samples from patients with acute COVID-19, infected either Delta or Omicron...
Several relatively recently published studies have shown changes in plasma metabolites various viral diseases such as Zika, Dengue, RSV or SARS-CoV-1. The aim of this study was to analyze the metabolome profile patients during acute COVID-19 approximately one month after infection and compare these results with healthy (SARS-CoV-2-negative) controls. analysis performed by NMR spectroscopy from peripheral blood samples were collected on 3 different occasions (at admission, hospitalization...
Background and Objectives: Immune checkpoint inhibitors such as PD-1 TIM-3 play an important role in regulating the host immune response are proposed potential prognostic markers therapeutic targets severe cases of COVID-19. We evaluated expression on T cells, well concentration sPD-1 plasma, to clarify these molecules patients infected with SARS-CoV-2. Materials Methods: In this retrospective observational study, we analysed CD4+ CD8+ cells upon admission after 7 days hospitalisation 770...
Familial Mediterranean fever (FMF) is the most common monogenic periodic syndrome among all autoinflammatory diseases. It characterised by recurrent, self-limited attacks of short duration, polyserositis symptoms, and elevated acute-phase reactants. FMF has highest prevalence in Eastern region. The first descriptions cases Central Europe date back to 2014. European region was previously estimated at 1:465,500 paediatric population, with data on adult lacking. Patients who fulfilled...
Background: COVID-19 represents a severe inflammatory condition. Our work was designed to monitor the longitudinal dynamics of metabolomic response blood plasma and reveal presumable discrimination in patients with positive negative outcomes respiratory symptoms. Methods: Blood from patients, divided into subgroups (survivors) (worsening condition, non-survivors) outcomes, on Days 1, 3, 7 after admission hospital, measured by NMR spectroscopy. Results: We observed changes energy metabolism...
Metabolomics is a relatively new research area that focuses mostly on the profiling of selected molecules and metabolites within organism. A SARS-CoV-2 infection itself can lead to major disturbances in metabolite profile infected individuals. The aim this study was analyze metabolomic changes urine patients during acute phase COVID-19 approximately one month after recovery period. We discuss observed relation alterations resulting from blood plasma metabolome, as described our previous...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that spread around the world during past years, has infected more than 260 million people worldwide and imposed an important burden on healthcare system. Several risk factors associated with unfavorable outcome were identified, including elderly age, selected comorbidities, immune suppression as well laboratory markers. The role of system in pathophysiology SARS-CoV-2 infection is indisputable: while appropriate function for a...
Background: Common variable immunodeficiency (CVID) is a heterogeneous group of immune disorders. The patients are classified according to the clinical manifestation with infection-only phenotype (CVIDinf) and CVID dysregulation (CVIDid). Methods: We performed retrospective analysis 64 (34 males, 53.13%; mean age: 41.4 years; SD: ±21.4 years). divided into subgroups (CVIDinf CVIDid) B cell phenotypic profiling after performing flow cytometry use EUROclass classification. compared...
•EUFOREA asthma pocket guide is an educational and practical tool for non-respiratory physicians, paramedics patients.•EUFOREA provides a simplified algorithm on diagnosis, treatment specialist referral.•EUFOREA living document which can be accessed at www.euforea.eu/news/asthma-pocket-guide. International national initiatives management provide extensive information pathophysiology, offering expert guidance diagnosis recommendations treatment, highlighting contemporary therapeutic options...
Introduction Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA) is the most frequent periodic fever in children. Its pathogenesis still unknown, but some disease-modifying factors were observed. Several medications tested for long-term prophylaxis of inflammatory flares; however, none are standardly used. Methods This prospective clinical trial enrolled 142 children (71 girls, 50%) meeting diagnostic criteria PFAPA syndrome. We analysed selected characteristics...