A5042864720- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Reproductive tract infections research
- Genetic factors in colorectal cancer
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Sarcoma Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Circular RNAs in diseases
- Biosensors and Analytical Detection
- Carcinogens and Genotoxicity Assessment
- COVID-19 Clinical Research Studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Birth, Development, and Health
Comenius University Bratislava
2015-2024
Coronavirus SARS-CoV-2 is a causative agent responsible for the current global pandemic situation known as COVID-19. Clinical manifestations of COVID-19 include wide range symptoms from mild (i.e., cough, fever, dyspnea) to severe pneumonia-like respiratory symptoms. has been demonstrated be detectable in stool patients. Waste-based epidemiology (WBE) shown promising approach early detection and monitoring local population performed via collection, isolation, viral pathogens environmental...
MicroRNAs (miRNAs) are one of the important regulators cellular functions fundamental for healthy pregnancy processes, including angiogenesis and differentiation trophoblast cells, their deregulation could be implicated in pathogenesis complications, preeclampsia (PE). The aim this study was to assess association miRNA expression plasma samples with PE, its onset, severity. Our enrolled 59 pregnant women, 27 preeclamptic group 32 control physiological pregnancy. Preeclamptic pregnancies were...
MicroRNAs in the circulation of breast cancer (BC) patients have great potential for early diagnosis, treatment and monitoring cancer. The aim this preliminary study was to obtain expression profile selected miRNAs plasma BC that could discriminate from healthy volunteers may be useful detection BC. Significantly deregulated were evaluated by pathway analysis with prediction miRNA targets. enrolled samples 65 34 volunteers. Selected screened pilot testing real-time PCR (qPCR) method, most...
Background: Cervical cancer is the fourth most common malignancy and leading cause of death in women worldwide. More than 99.7% cases are caused by human papillomavirus (HPV), while HPV types 16 18 over 70% all cervical cases. In this preliminary study, we aimed to investigate presence infection diversity bacteria associated with bacterial vaginosis. Methods: swabs (n = 21) taken from aged 21–47 years, seventeen cases, different degrees abnormality, four healthy women, were tested for DNA,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monitoring in air traffic is important the prevention of virus spreading from abroad. The gold standard for SARS-CoV-2 detection RT-qPCR; however, early and low viral load detection, a much more sensitive method, such as droplet digital PCR (ddPCR), required. Our first step was to developed both, ddPCR RT-qPCR methods, detection. Analysis ten swab/saliva samples five Covid-19 patients different stages disease showed positivity 6/10...
Cervical cancer is the fourth leading cause of mortality in females worldwide. Infection with high-risk human papillomavirus (HPV) essential but insufficient to cervical cancer, and clearance HPV infection mediated by immune system. The deficit molecules responsible for adhesion may play a role development cancer. E-cadherin encoded cadherin 1 (CDH1) gene, involved cell forming adherens junctions. aim present study was investigate methylation pattern CDH1 promoter identify association...
The global pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) is having a tremendous impact on economy, health care systems and lives almost all people in world. Central European country Slovakia reached one highest daily mortality rates per 100,000 inhabitants first 3 months 2021, despite implementing strong prophylactic measures, lockdowns repeated nationwide antigen testing. present study reports comparison performance Standard Q...
The aim of our study was to assess the correlation between tobacco exposure and NAT2 gene (rs1041983 C/T, rs1801280 T/C, rs1799930 G/A) polymorphisms in association with breast cancer development. We wanted determine prognostic clinical importance these smoking cancer. For detection possible smoking, polymorphisms, risk cancer, we designed a case-controlled 198 patients enrolled, 98 100 healthy controls. Ten milliliters peripheral blood from cubital vein withdrawn every patient. HRM (high...
Background The mutations in the RPGR (retinitis pigmentosa GTPase regulator) gene are most common cause of X-linked retinitis (XLRP), a rare genetic disorder affecting photoreceptor cells retina. Several reported cases identified this as link between (RP) and primary ciliary dyskinesia (PCD), characterised by impaired function predominantly respiratory tract. Since different same can result various clinical manifestations, it is important to describe correlation variant observed phenotype....
Preeclampsia (PE) is a pregnancy specific disease with several risk factors such as genetic polymorphisms, environmental and social participating in its development.The aim of this study was to investigate whether distribution three putative regulatory SNPs rs13430086, rs5186, rs4606 3'UTR genes ACVR2A, AGTR1 RGS2, respectively, that have been associated hypertension regulation trophoblast invasion differ between women PE control group.The associations rs5186 preeclampsia were tested two...
Aims: This study investigated the presence of human papillomavirus (HPV) infection and methylation status promoters cell adhesion molecule 1 (CADM1) gene T lymphocyte maturation associated protein (MAL) in patients with cervicitis/inflammation cervical intraepithelial neoplasia (CIN). Materials Methods: Cervical specimens (n = 47) were collected from women normal cytology 21) those abnormalities 26). The HPV was confirmed by an DNA test mRNA (Aptima test). Methylation levels CADM1 MAL...
Colorectal cancer (CRC) is the third-most common type in males and second-most females, has second-highest overall mortality rate worldwide. Approximately 50% of patients stage I-III develop metastases, mostly localized to liver. All physiological conditions occurring organism are also reflected levels circulating microRNAs (miRNAs/miRs) patients. miRNAs a class small, non-coding, single-stranded RNAs consisting 18-25 nucleotides, which have important roles various cellular processes. The...