A5018023586- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Microscopic Colitis
- Nutrition and Health in Aging
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Digestive system and related health
- Infant Nutrition and Health
- Clinical Nutrition and Gastroenterology
- GDF15 and Related Biomarkers
- Gastrointestinal motility and disorders
- IL-33, ST2, and ILC Pathways
- Chronic Disease Management Strategies
- Dysphagia Assessment and Management
- Marketing and Advertising Strategies
- Autoimmune and Inflammatory Disorders Research
- Microbial Metabolites in Food Biotechnology
- Food composition and properties
- Clostridium difficile and Clostridium perfringens research
- Autoimmune and Inflammatory Disorders
University of Glasgow
2020-2025
Glasgow Royal Infirmary
2020-2025
Clinical Trial Investigators
2025
Royal Hospital for Sick Children
2021
Royal Hospital for Children
2021
Harokopio University of Athens
2016
Summary Background Exclusive enteral nutrition (EEN) is an effective treatment for Crohn's disease. Aims To investigate the hypothesis that ingredients of EEN formulas are unlikely to initiate a disease flare and their dietary elimination not essential amelioration. Methods We performed compositional analysis with evidence efficacy in management active Macronutrient content was compared against reference values (DRV), UK National Diet Nutrition Survey (NDNS) intake children. Food additives...
PGE 2 inhibits T regs and promotes intestinal inflammation through actions on mononuclear phagocytes the gut microbiota.
Predicting response to exclusive enteral nutrition (EEN) in active Crohn's disease (CD) could lead therapy personalization and pretreatment optimization.
Abstract Background and aims This study to profile biomarkers of dietary intake in faeces children with Crohn’s disease (CD) explore their role recurrence following induction treatment exclusive enteral nutrition. Methods We will quantify 928 banked faecal samples 116 CD collected during the first 30 days food reintroduction, successful nutrition (EEN), spot from 53 matched healthy controls. In samples, a wide range carbohydrates (e.g. galactose, rhamnose, glucose, xylose), polysaccharides...
Abstract Background Patients with inflammatory bowel disease (IBD) often use the Internet to seek information beyond that received from healthcare professionals. This study assessed perceptions of YouTube presenters on role diet in management IBD. Methods Videos discussing dietary aspects (food, diet-related items, and advisory comments [FODRIACs]) IBD were included. The toward each FODRIAC labeled as positive, negative, or neutral/intermediate, FODRIACs classified according their underlying...
ABSTRACT It remains unclear whether suboptimal response to exclusive enteral nutrition (EEN) in some children with Crohn disease (CD) is explained by poor compliance. The present study measured faecal gluten immunogenic peptides (GIP), a biomarker of intake, 45 (3– 17 years) CD, and explored associations calprotectin (FC) levels at 33 54 days EEN. FC decreased patients undetectable GIP both EEN (mean decrease, days: −743 mg/kg, –1043 P < 0.001) but not who had detectable levels. At...
Enteral nutrition (EN) involves replacing all or part of a person's habitual diet with nutritional formula. The impact varying doses EN on the gut microbiome remains understudied.
Abstract Background and Aims Treatment adherence is key to the efficacy of exclusive enteral nutrition [100% EN] in active Crohn’s disease [CD], but there are no biomarkers objectively estimate this. We explored faecal parameters as compliance with 100% EN, subsequently developed validated Glasgow Exclusive Enteral Nutrition Index Compliance [GENIE]. Methods Healthy adults replaced all or part [85% 50% 20% their diet a formula for 7 days. Faecal pH, water content, short chain fatty acids,...
Abstract Background The anti-inflammatory effect of exclusive enteral nutrition on the gut children with Crohn’s disease is rapidly lost after food reintroduction. This study assessed dietary triggers following successful treatment nutrition. Methods Nutrient intake, patterns and biomarkers in faeces (gluten immunogenic peptides, undigestible starch, short chain fatty acids) were 14 during early reintroduction, Groups above (Group A) below B) median levels faecal calprotectin reintroduction...
Abstract Background Exclusive enteral nutrition (EEN) is a main therapy for active Crohn’s disease (CD) in children, but normalisation of faecal calprotectin (FCAL) varies among patients, even those who enter clinical remission. To better understand characteristics related to EEN efficacy and its mechanism action, we compared microbial parameters between patients whose FCAL normalised against did not at completion. Methods Children with CD, clinically responding EEN, were recruited from 11...
Abstract Background Faecal calprotectin (FCAL) rises rapidly in children with Crohn’s disease (CD) following treatment exclusive enteral nutrition (EEN). We aimed to identify clinical, dietary and diet-related microbial metabolites which associate the recurrence of FCAL above 250 mg/kg after 21 days food reintroduction. Methods Children CD (age 6-17 years), clinically responding EEN, were recruited, prospectively, from 11 UK hospitals (January 2020-May 2023, NCT04225689). They provided a...
Abstract Background Treatment with exclusive enteral nutrition (EEN) offers a nutritional therapy paradigm in Crohn’s disease, the extensive modulation of gut microbiome being its proposed mechanism action (1). Recent studies propose variable clinical efficacy for 85% EN (Cheat EN/CEN), 50% (Partial EN/PEN) and 20% (maintenance EN/MEN), dose-dependent effect use CD (2–5). Therefore, this study aims to investigate 100%, 85%, 50%, on faecal microbial metabolites; if can be used as compliance...
<h3>Introduction</h3> Treatment with exclusive enteral nutrition (EEN) offers a nutritional therapy paradigm in Crohn's disease, the extensive modulation of gut microbiome being its proposed mechanism action(1). Recent studies propose variable clinical efficacy for 85% EN (Cheat EN/CEN), 50% (Partial EN/PEN) and 20% (maintenance EN/MEN), dose-dependent effect use CD(2–4). Therefore, this study aims to investigate 100%, 85%, 50%, on faecal microbial metabolites; if can be used as compliance...
Abstract Background Treatment adherence is key to the efficacy of exclusive enteral nutrition (100% EN) in active Crohn’s disease (CD), but there are currently no biomarkers objectively support this. We explored faecal parameters as putative compliance with 100% EN, and subsequently developed validated Glasgow Exclusive Nutrition Index compliancE (GENIE). Methods Healthy adults replaced all or part (85% 50% EN 25% their habitual diet a polymeric formula (Modulen IBD, Nestle©) for 7 days....
Abstract Background Exclusive enteral nutrition (EEN) ameliorates gut inflammation in children with Crohn’s disease (CD). We have previously described the rapid rise faecal calprotectin levels (FC) when CD return to their habitual diet after EEN treatment (1). performed dietary assessment and measured biomarkers of food consumption faeces during early reintroduction. Methods A composite outcome clinical remission post (weighted Paediatric Disease Activity Index &lt;12.5) a significant...
Abstract Background Exclusive enteral nutrition (EEN) is an effective treatment of Crohn’s disease (CD). We hypothesise that food ingredients which are included in EEN formulas less likely to initiate a flare and their dietary elimination not essential for amelioration. Methods performed compositional analysis with evidence clinical efficacy the induction remission active CD. Macronutrient content was compared against reference values (DRVs), UK National Diet Nutrition Survey (NDNS) children...