A5022254577- Inflammatory Bowel Disease
- Microscopic Colitis
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Eosinophilic Esophagitis
- GDF15 and Related Biomarkers
- Infant Nutrition and Health
- Nutrition and Health in Aging
- Biomedical Text Mining and Ontologies
- Celiac Disease Research and Management
- Intestinal Malrotation and Obstruction Disorders
- Drug Transport and Resistance Mechanisms
- Diverticular Disease and Complications
- Intestinal and Peritoneal Adhesions
- Clinical Nutrition and Gastroenterology
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Congenital Diaphragmatic Hernia Studies
- Stoma care and complications
- Child Nutrition and Water Access
University of Glasgow
2017-2024
Glasgow Royal Infirmary
2019-2024
Summary Background Exclusive enteral nutrition (EEN) is an effective treatment for Crohn's disease. Aims To investigate the hypothesis that ingredients of EEN formulas are unlikely to initiate a disease flare and their dietary elimination not essential amelioration. Methods We performed compositional analysis with evidence efficacy in management active Macronutrient content was compared against reference values (DRV), UK National Diet Nutrition Survey (NDNS) intake children. Food additives...
Faecal calprotectin decreases during exclusive enteral nutrition in children with active Crohn's disease. It is unknown how faecal changes food re-introduction and the influence of maintenance nutrition.To study to at reintroduction, explore associations nutrition.Children disease were followed food-reintroduction. was measured before, 33 54 days nutrition, 17, 52 72 after Maintenance use recorded estimated weight diaries. Data are presented medians Q1:Q3.Sixty-six patients started 41 (62%)...
Predicting response to exclusive enteral nutrition (EEN) in active Crohn's disease (CD) could lead therapy personalization and pretreatment optimization.
The predominance of specific bacteria such as adherent-invasive Escherichia coli (AIEC) within the Crohn's disease (CD) intestine remains poorly understood with little evidence uncovered to support a selective pressure underlying their presence. Intestinal ethanolamine is however readily accessible during periods intestinal inflammation, and enables pathogens outcompete host microbiota under circumstances.Quantitative RT-PCR (qRT-PCR) determine expression genes central metabolism;...
There is a clinical need to develop biomarkers of small bowel damage in coeliac disease and Crohn's disease. This study evaluated intestinal fatty acid binding protein (iFABP), potential biomarker damage, children with disease.The concentration iFABP was measured plasma urine ulcerative colitis, disease, at diagnosis from the latter two groups after treatment gluten free diet (GFD) or exclusive enteral nutrition (EEN), respectively. Healthy (Controls) were also recruited.138 recruited....
ABSTRACT It remains unclear whether suboptimal response to exclusive enteral nutrition (EEN) in some children with Crohn disease (CD) is explained by poor compliance. The present study measured faecal gluten immunogenic peptides (GIP), a biomarker of intake, 45 (3– 17 years) CD, and explored associations calprotectin (FC) levels at 33 54 days EEN. FC decreased patients undetectable GIP both EEN (mean decrease, days: −743 mg/kg, –1043 P < 0.001) but not who had detectable levels. At...
Exclusive enteral nutrition (EEN) is an effective treatment for active Crohn's disease (CD). This study explored the immunostimulatory potential of a cell-free fecal filtrate and related this with changes in microbiota metabolites children CD undertaking EEN.
Abstract Background The anti-inflammatory effect of exclusive enteral nutrition on the gut children with Crohn’s disease is rapidly lost after food reintroduction. This study assessed dietary triggers following successful treatment nutrition. Methods Nutrient intake, patterns and biomarkers in faeces (gluten immunogenic peptides, undigestible starch, short chain fatty acids) were 14 during early reintroduction, Groups above (Group A) below B) median levels faecal calprotectin reintroduction...
Abstract Background Exclusive enteral nutrition (EEN) is an established induction treatment for active Crohn’s disease (CD) with a proposed mechanism of action involving the gut microbiome. We have previously shown that CD-TREAT diet, food-based diet similar dietary profile to EEN, improves rat ileitis and replicates effect EEN on microbiome healthy volunteers animal models. Here, we test efficacy induce clinical remission in CD. Methods This open-label study children (wPCDAI≥12.5) adults...
Abstract Background Exclusive enteral nutrition (EEN) is the recommended induction treatment of mild to moderate active pediatric Crohn’s disease (CD). This study compared outcomes 2 proprietary polymeric formulas. Treatment effectiveness was examined along with practical aspects formula delivery and differences in estimated costs. Methods Data were retrospectively collected from patients CD who received a generic oral nutritional supplement (Fortisip) across centers (RCH, Melbourne RHSC,...
With an unprecedented growth in the biomedical literature, keeping up to date with new developments presents immense challenge. Publications are often studied isolation of established interpretation being subjective and introducing human bias. ontology-driven annotation data gaining popularity recent years online databases offering metatags rich textual information, it is now possible automatically text-mine ontological terms complement laborious task manual management, interpretation,...
<h3>Introduction</h3> To characterise the microbiome composition and functionality in paediatric Crohn's disease (CD) patients during a course of exclusive enteral nutrition (EEN) subsequent food-reintroduction <h3>Methods</h3> CD were recruited between August 2014-June 2016. Patients treated with an 8 wk EEN. Clinical activity was defined using weighted index (wPCDAI). Serial faecal samples collected prior to EEN, at 30d 56d two further post-EEN (17d 52d) food re-introduction (FR)....
With an unprecedented growth in the biomedical literature, keeping up to date with new developments presents immense challenge. Publications are often studied isolation of established interpretation being subjective and introducing human bias. ontology-driven annotation data gaining popularity recent years online databases offering metatags rich textual information, it is now possible automatically text-mine ontological terms complement laborious task manual management, interpretation,...
With an unprecedented growth in the biomedical literature, keeping up to date with new developments presents immense challenge. Publications are often studied isolation of established interpretation being subjective and introducing human bias. ontology-driven annotation data gaining popularity recent years online databases offering metatags rich textual information, it is now possible automatically text-mine ontological terms complement laborious task manual management, interpretation,...
The predominance of specific bacteria within the Crohn’s disease intestine remains poorly understood with little evidence uncovered to support a selective pressure underlying their presence. Intestinal ethanolamine is readily accessible during periods intestinal inflammation, and enables pathogens outcompete host microbiota under such circumstances. Here we show that short chain fatty acid propionic stimulates increased degradation by one associated pathogen, adherent-invasive Escherichia...
Abstract Background Exclusive enteral nutrition (EEN) ameliorates gut inflammation in children with Crohn’s disease (CD). We have previously described the rapid rise faecal calprotectin levels (FC) when CD return to their habitual diet after EEN treatment (1). performed dietary assessment and measured biomarkers of food consumption faeces during early reintroduction. Methods A composite outcome clinical remission post (weighted Paediatric Disease Activity Index &lt;12.5) a significant...
Abstract Background The ability of adherent-invasive E. coli (AIEC), to adhere and invade intestinal epithelial cells survive autophagy implicates them in the pathogenesis Crohn’s disease (CD). Previous studies focused mostly on differences abundance between patients with CD healthy controls. Here, we studied changes levels, strains their utilise carbon sources during treatment exclusive enteral nutrition (EEN), at food reintroduction, compared Methods were isolated from culturing stool...
Abstract Background Exclusive enteral nutrition (EEN) is an effective treatment of Crohn’s disease (CD). We hypothesise that food ingredients which are included in EEN formulas less likely to initiate a flare and their dietary elimination not essential for amelioration. Methods performed compositional analysis with evidence clinical efficacy the induction remission active CD. Macronutrient content was compared against reference values (DRVs), UK National Diet Nutrition Survey (NDNS) children...
Abstract Background It is yet unclear whether suboptimal response to exclusive enteral nutrition (EEN), in some children with Crohn’s disease (CD), explained by poor compliance. All proprietary feeds used for EEN are gluten-free; hence patients’ compliance could be determined detecting gluten immunogenic peptide (GIP), a biomarker of intake, faeces. Methods The concentration GIP was measured the faeces of, 45 (3–17 years) CD prior and during (33 &, 54 days) treatment EEN. Associations...
<h3>Introduction</h3> Exclusive enteral nutrition (EEN) ameliorates gut inflammation in children with Crohn's disease (CD). We have previously described the rapid rise faecal calprotectin levels (FC) when CD return to their habitual diet after EEN treatment.<sup>1</sup> explored dietary triggers of relapse by performing assessment and measuring food biomarkers during early reintroduction. <h3>Methods</h3> Combination clinical remission post (weighted Paediatric Disease Activity Index...
Abstract Background Exclusive enteral nutrition (EEN) is the recommended first line treatment for active paediatric Crohn’s disease (CD). The mechanism of action and immunological effects EEN remain unclear. This study compared circulating inflammatory proteins patients with CD ulcerative colitis (UC) non-inflammatory bowel (non-IBD) controls explored effect in children CD. Methods Patients were treated 8 weeks, plasma samples collected prior to start upon completion. Levels 92 quantified...
Abstract Background Induction of clinical remission with exclusive enteral nutrition (EEN), has been associated accompanying changes in the concentration short chain fatty acids (SCFA) (a biomarker fibre fermentation) faeces children Crohn’s disease (CD) 1. Here, we assessed fermentative capacity gut microbiota active CD vitro, before, during and after EEN compared healthy children. Methods 44 faecal samples from 14 (female, n=7, age, median [Q1, Q3]: 14.1 [11.1, 15.1] years) were collected...