A5031532467- Inflammatory Bowel Disease
- Nutrition and Health in Aging
- Infant Nutrition and Health
- Digestive system and related health
- Nutritional Studies and Diet
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Fluoride Effects and Removal
- Microscopic Colitis
- GDF15 and Related Biomarkers
- Child Nutrition and Water Access
- Eosinophilic Esophagitis
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
Glasgow Royal Infirmary
2021-2024
University of Glasgow
2021-2024
Glasgow Life
2022
ABSTRACT It remains unclear whether suboptimal response to exclusive enteral nutrition (EEN) in some children with Crohn disease (CD) is explained by poor compliance. The present study measured faecal gluten immunogenic peptides (GIP), a biomarker of intake, 45 (3– 17 years) CD, and explored associations calprotectin (FC) levels at 33 54 days EEN. FC decreased patients undetectable GIP both EEN (mean decrease, days: −743 mg/kg, –1043 P < 0.001) but not who had detectable levels. At...
Background & aimsThe use of handgrip strength (HGS) as a proxy nutritional status in sick children has not been studied. This study created HGS centile charts healthy and explored the utility z-scores markers body composition screening malnutrition risk children.MethodsData from 535 aged 5–16 years were used for development centiles adjusted either age or height. In 595 children, relationships between with composition, (Paediatric Yorkhill Malnutrition Score-PYMS), length hospital stay (LOS)...
Abstract Background Exclusive enteral nutrition (EEN) is an established induction treatment for active Crohn’s disease (CD) with a proposed mechanism of action involving the gut microbiome. We have previously shown that CD-TREAT diet, food-based diet similar dietary profile to EEN, improves rat ileitis and replicates effect EEN on microbiome healthy volunteers animal models. Here, we test efficacy induce clinical remission in CD. Methods This open-label study children (wPCDAI≥12.5) adults...
Liquid chromatography coupled with mass spectrometry (LC-MS) metabolomic approaches are widely used to investigate underlying pathogenesis of gastrointestinal disease and mechanism action treatments. However, there is an unmet requirement assess faecal metabolite extraction methods for large-scale metabolomics studies. Current often rely on biphasic extractions using harmful halogenated solvents, making automation studies challenging. The present study reports optimised monophasic protocol...
Abstract Background Exclusive enteral nutrition (EEN) is a main therapy for active Crohn’s disease (CD) in children, but normalisation of faecal calprotectin (FCAL) varies among patients, even those who enter clinical remission. To better understand characteristics related to EEN efficacy and its mechanism action, we compared microbial parameters between patients whose FCAL normalised against did not at completion. Methods Children with CD, clinically responding EEN, were recruited from 11...
Abstract Background Faecal calprotectin (FCAL) rises rapidly in children with Crohn’s disease (CD) following treatment exclusive enteral nutrition (EEN). We aimed to identify clinical, dietary and diet-related microbial metabolites which associate the recurrence of FCAL above 250 mg/kg after 21 days food reintroduction. Methods Children CD (age 6-17 years), clinically responding EEN, were recruited, prospectively, from 11 UK hospitals (January 2020-May 2023, NCT04225689). They provided a...
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Endemic fluorosis refers to the condition when individuals are exposed excessive amounts of fluoride ion due living in a region characterized by elevated levels fluorine drinking water, food, and/or air. In Pakistan, substantial proportion population is thereby affected, posing public health concern.
Abstract Background Treatment with the CD-TREAT solid food diet improves disease activity indices, faecal calprotectin (FCAL) levels and quality of life in adults children active Crohn’s (CD); particularly patients who adhere to diet. Here we describe changes microbiome parameters during therapy explore these against adherence. Methods Children adult CD completed an 8-week treatment CD-TREAT. The FCAL, pH, total sulphide (colorimetry), short chain fatty acids (SCFA), branched (BCFA) (gas...
Abstract Background It is yet unclear whether suboptimal response to exclusive enteral nutrition (EEN), in some children with Crohn’s disease (CD), explained by poor compliance. All proprietary feeds used for EEN are gluten-free; hence patients’ compliance could be determined detecting gluten immunogenic peptide (GIP), a biomarker of intake, faeces. Methods The concentration GIP was measured the faeces of, 45 (3–17 years) CD prior and during (33 &, 54 days) treatment EEN. Associations...
Abstract Liquid chromatography coupled with mass spectrometry (LC-MS) metabolomic approaches are widely used to investigate underlying pathogenesis of gastrointestinal disease and mechanism action treatments. However, a standardised method for extracting metabolites from faecal samples large-scale studies is yet be defined. Current methods often rely on biphasic extractions using harmful halogenated solvents, making automation challenging. The present study reports an optimised monophasic...