A5014914430- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac and Coronary Surgery Techniques
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- Inflammatory mediators and NSAID effects
- Cardiac Fibrosis and Remodeling
- Cardiac tumors and thrombi
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
Charles University
2016-2025
University Hospital Kralovske Vinohrady
2016-2025
Palacký University Olomouc
2024
Czech Academy of Sciences, Institute of Scientific Instruments
2020
Ocní klinika
2010-2016
Janssen (United States)
2016
In-Q-Tel
2009
Prague University of Economics and Business
2004
Leipzig University
2002
University Hospital Leipzig
2001
Nonselective His-bundle pacing (nsHBp), nonselective left bundle branch (nsLBBp), and ventricular septal myocardial (LVSP) are recognized as physiological techniques.The purpose of this study was to compare differences in depolarization between these techniques using ultra-high-frequency electrocardiography (UHF-ECG).In patients with bradycardia, nsHBp, nsLBBp (confirmed concomitant [LBB] capture), LVSP (pacing [LV] position without proven LBB capture) were performed. Timings activations...
Abstract Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), which pre-clinical and early-stage clinical data are suggestive some degree preferentiality to myocardial tissue without damage adjacent structures. Here in MANIFEST-17K study we assessed safety PFA by studying post-approval use this modality. Of 116 centers performing with a pentaspline catheter, were received from 106 (91.4% participation) regarding 17,642 patients undergoing (mean...
Hemolysis-related renal failure has been described after pulmonary vein isolation (PVI) with pulsed field ablation (PFA). To compare the potential for hemolysis during PVI PFA versus radiofrequency (RFA). In consecutive patients, was performed or RFA. Blood samples were drawn at baseline, immediately post-ablation, and 24 hours post-ablation. Using flow cytometry, concentration of red blood cell microparticles (RBCμ, fragments damaged erythrocytes) in also assessed. Lactate-dehydrogenase...
Abstract A significant proportion of patients who suffer from atrial fibrillation and are in need thromboembolic protection not treated with oral anticoagulation or discontinue this treatment shortly after its initiation. This undertreatment has improved sufficiently despite the availability direct anticoagulants which associated less major bleeding than vitamin K antagonists. Multiple reasons account for this, including events ischaemic strokes whilst on anticoagulation, a serious risk...
AimsSurgical ablation procedure can restore sinus rhythm (SR) in patients with atrial fibrillation (AF) undergoing cardiac surgery. However, it is not known whether has any impact on long-term clinical outcomes.
Left bundle branch pacing (LBBP) produces delayed, unphysiological activation of the right ventricle. Using ultra-high-frequency electrocardiography (UHF-ECG), we explored how bipolar anodal septal with direct LBB capture (aLBBP) affects resultant ventricular depolarization pattern.In patients bradycardia, His (HBP), unipolar nonselective LBBP (nsLBBP), aLBBP, and (RVSP) were performed. Timing local activation, in leads V1-V8, was displayed using UHF-ECG, electrical dyssynchrony (e-DYS)...
Pulsed-field ablation (PFA) represents a new, non-thermal energy for the of AF. Ablation energies producing thermal injury are associated with an inflammatory response, platelet, and coagulation activation. The study aimed to compare systemic response in patients undergoing PVI using PF radiofrequency (RF) energy. Patients AF indicated were enrolled randomly assigned undergo RF (CARTO Smart Touch, Biosense Webster) or (Farapulse, Boston-Scientific) Markers myocardial damage (troponin I),...
Biventricular pacing (Biv) and left bundle branch area (LBBAP) are methods of cardiac resynchronization therapy (CRT). Currently, little is known about how they differ in terms ventricular activation. This study compared activation patterns block (LBBB) heart failure patients using an ultra-high-frequency electrocardiography (UHF-ECG). was a retrospective analysis including 80 CRT from two centres. UHF-ECG data were obtained during LBBB, LBBAP, Biv. Left divided into non-selective (NSLBBP)...
Abstract Aims Data on the hybrid atrial fibrillation (AF) treatment are lacking in patients with structural heart disease undergoing concomitant CryoMaze procedures. The aim was to assess whether timely pre-emptive catheter ablation would achieve higher freedom from AF or tachycardia (AT) and be associated better clinical outcomes than surgical alone. Methods results trial investigated non-paroxysmal coronary artery bypass grafting and/or valve repair/replacement mandatory procedure who were...
The aim of the study was to verify correct anchoring location for tip right ventricular lead using cardiac computed tomography and assess best fluoroscopic ECG criteria associated with electrode into midseptum.Patients indicated pacemaker implantation were prospectively enrolled. implanted midseptum according standard in left anterior oblique 40 view. shadow on 30 divided 4 quadrants perpendicular lateral silhouette position analyzed. exact assessed tomography. Of 51 patients, anchored 21...
The present study introduces a new ultra-high-frequency 14-lead electrocardiogram technique (UHF-ECG) for mapping ventricular depolarization patterns and calculation of novel dyssynchrony parameters that may improve the selection patients application cardiac resynchronization therapy (CRT).Components ECG in sixteen frequency bands within 150 to 1000 Hz range were used create maps. maximum time difference between UHF QRS complex centers mass leads V1 V8 was defined as electrical (e-DYS),...
Background: Three different ventricular capture types are observed during left bundle branch pacing (LBBp). They selective LBB (sLBBp), non-selective (nsLBBp), and myocardial septal transiting from nsLBBp while decreasing the output (LVSP). Study aimed to compare differences in depolarization between these captures using ultra-high-frequency electrocardiography (UHF-ECG). Methods: Using decremental voltage output, we identified studied nsLBBp, sLBBp, LVSP patients with bradycardia. Timing of...
Abstract Background Right ventricular (RV) pacing causes delayed activation of remote segments. We used the ultra‐high‐frequency ECG (UHF‐ECG) to describe depolarization when different RV locations. Methods In 51 patients, temporary was performed at septum (mSp); further subclassified as right inflow tract (RVIT) and outflow (RVOT) for septal positions (below or above plane His bundle in anterior oblique), apex, lateral wall, basal with nonselective RBB capture (nsHBorRBBp). The timings...
The effect of left ventricular myocardial septal (LVSP) and bundle branch pacing (LBBP) on synchrony LV hemodynamics is poorly understood. To investigate the impact LVSP LBBP versus biventricular (BVP) electrical in CRT patients. In candidates with conduction disease, was assessed by measuring QRSd using ultra-high-frequency ECG (UHF-ECG). (lv-DYS) as a difference between first activation V1-V8 to last from V4-V8. estimated invasive systolic blood pressure measurement during multiple...
Electrical cardioversion presents one of the treatment options for atrial fibrillation (AF). However, early recurrence rate is high, reaching ~40% three months after procedure. Features based on vectorcardiographic signals were explored to find association with AF. Eighty-four patients non-paroxysmal AF referred electrical prospectively studied; was present in 40 (47.6%). Patients underwent 24-h Holter ECG monitoring procedure assess recurrence. Pre-procedural 12-lead ECGs (10 s, 1 kHz)...