A5101791898- Muscle Physiology and Disorders
- Immune Response and Inflammation
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Milk Quality and Mastitis in Dairy Cows
- Growth Hormone and Insulin-like Growth Factors
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Electron Spin Resonance Studies
- Radiopharmaceutical Chemistry and Applications
- Reproductive Physiology in Livestock
- Medical Imaging Techniques and Applications
- T-cell and Retrovirus Studies
- Glycosylation and Glycoproteins Research
- Neuropeptides and Animal Physiology
- Antimicrobial Peptides and Activities
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
Toyota Motor North America (United States)
2023
Michigan United
2023
Toyota Research Institute
2023
Harvard University
2023
University of Occupational and Environmental Health Japan
2011-2023
Gifu Municipal Hospital
2023
University of Tsukuba
2022
Gifu University
2016-2021
Gifu University Hospital
2015-2021
Tottori University
2020
Serotonin is synthesized by two distinct tryptophan hydroxylases, one in the brain and periphery. The latter known to be unable cross blood-brain barrier. These serotonin systems have apparently independent functions, although functions of peripheral yet fully elucidated. In this study, we investigated physiological effect on concentrations metabolites circulation liver. After fasting, mice were ip injected with 1 mg serotonin. plasma glucose concentration was significantly elevated between...
To behave adaptively, animals must learn to predict future reward, or value. do this, are thought reward predictions using reinforcement learning. However, in contrast classical models, estimate value only incomplete state information. Previous work suggests that partially observable tasks by first forming "beliefs"-optimal Bayesian estimates of the hidden states task. Although this is one way solve problem partial observability, it not way, nor most computationally scalable solution...
Recently, several reports have demonstrated that fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in differentiating b e t w n i g a d m l s o h gallbladder.However, there limitation the ability of FDG-PET to differentiate between inflammatory and malignant lesions.We herein present case xanthogranulomatous cholecystitis misdiagnosed as gallbladder carcinoma by ultrasonography c p u ra hy. F D G -P E T increased activity.In this case, findings resulted...
Abstract Intrauterine administration of peripheral blood mononuclear cells (PBMCs) prior to bovine embryo transfer (ET) was previously shown improve the pregnancy rate. To better understand how PBMCs rate, we examined gene expression in from uterine lumen and evaluated morphology pre‐attachment embryos utero following intrauterine PBMCs. On day 3 estrous cycle (day 0 = estrous), were isolated suspended RPMI 1640, incubated for 24 hr. The cultured administered non‐surgically horn ipsilateral...
We studied the morphologic, immunohistochemical, and clinical characteristics of 158 cases lymphoblastic lymphoma. Based on immunophenotyping cell lineage, were classified into B-cell type (CD20,CD19 or CD79a+, n = 53), T-cell (surface CD3+, 84), non-B, non-T (B marker- surface CD3-, 21). The latter group was further divided based immunohistochemistry into: 1) CD7+ stem lymphoma (CD7+SCL) [CD4-, CD7+, CD33+/-, CD56-], 2) blastic natural killer (B-NKL) CD7+/-, CD33-, CD56+, CD123-], 3)...
ABSTRACT Saliva contains a number of proteins and glycoproteins that protect oral tissues, but little is known about the role human saliva in innate immunity. Here we showed major salivary gland cells constitutively expressed bacterial pattern recognition receptor, CD14, by immunohistochemistry. Human culture express CD14 mRNA 55-kDa protein in, not on cells, secrete soluble form with same molecular mass. whole concentration parotid was 10-fold higher than saliva, which comparable to serum...
The ability of Lactobacillus gasseri, a dairy lactic acid bacterium, to induce interferon (IFN) was investigated in murine macrophage cultures. IFNα substantially induced by some strais L. gasseri and the titers were highest at concentration 100 μg ml−1 DSM20243T. expression mRNA encoding detected spleen-macrophages (SP-Mθ) Peyer's patch-adherent cells stimulated with Actinomycin D cycloheximide added SP-Mθ cultures showed that synthesized 0.5 h, produced within 3 6 h after stimulation...
Abstract The transforming growth factor (TGF)‐β inducible early gene (TIEG)‐1 is implicated in the control of cell proliferation, differentiation, and apoptosis some types. Since TIEG1 functioning may be associated with TGF‐β, a suppressor myogenesis, also likely to involved myogenesis. Therefore, we investigated function during myogenic differentiation vitro using murine myoblasts line, C2C12. expression increased C2C12 cells. Constitutive reduced survival decreased myotube formation....
Primary hepatic lymphoma (PHL) is an extremely rare disease, frequently associated with viruses such as hepatitis B virus (HBV), C (HCV), and human immune deficiency (HIV). On the other hand, increased risk of lymphoproliferative disorders (LPD) has been demonstrated in patients treated immunosuppressive drugs methotrexate (MTX) for rheumatoid arthritis (RA). The role Epstein-Barr (EBV) discussed pathogenesis immunodeficiency-associated LPDs. We here describe a RA patient, who developed PHL...
Although the technical developments of radiotherapy have been remarkable, there are currently few reports on treatment results for local recurrence rectal cancer treated with surgery alone as initial in this three-dimensional conformal era. Thus, we retrospectively evaluated treatment.Thirty-two patients who underwent were enrolled study. The dose per fraction was 2.0-3.5 Gy. Because schedule variable, biological effective (BED) calculated.Local control (LC) and overall survival (OS) rates...
ABSTRACT Myostatin (MSTN) is a negative regulator during muscle differentiation, whereas insulin‐like growth factors (IGFs) are essential for development. MSTN and IGFs act oppositely myogenesis, but there little information on the mutual relationship of IGFs. The present study was conducted to examine whether affects IGF expression early myogenesis in cattle. IGF‐1 mRNA similarly expressed M. longissimus thoracis double‐muscled (DM) normal (NM) Japanese shorthorn IGF‐2 consistently higher...
We previously reported that the transcription factor Zinc Finger Protein 143 (ZNF143) regulates expression of genes associated with cell cycle and division, downregulation ZNF143 induces arrest at G2/M. To assess function in cycle, we established two cells forced derived from PC3 prostate cancer lines. These lines overexpress such as polo-like kinase 1 (PLK1), aurora B (AURKB) some minichromosome maintenance complex components (MCM). However, doubling time was approximately twice long its...
Abstract To investigate the role of human gingival fibroblasts (HGF), major constituents tissue in periodontal inflammatory disease, expression interleukin-2 receptor (IL-2R) α, β, and γ chains was examined. Immunohistochemistry showed a pronounced accumulation CD8+ T cells inflamed lamina propria from patients with adult periodontitis. HGF express IL-2Rβ IL-2Rγ at mRNA protein levels, but IL-2Rα could not be detected, as assessed by reverse transcriptase-polymerase chain reaction flow...
To assess if intravoxel incoherent motion (IVIM) imaging can be used to predict early response chemoradiotherapy (CRT) in cervical cancer. IVIM before and during CRT (at doses of 20 40 Gy) was performed 17 patients with squamous cell carcinoma. The percentage changes parameters were significantly higher for complete remission (CR) than non-CR groups. may play a supplementary role predicting
The purpose of this multi-institutional Phase II trial study was to prospectively investigate the efficacy herbal medicine TJ-14 for acute radiation-induced enteritis (ARE). administered orally as a first-line treatment ARE. primary end point at 1 week. secondary points were: (i) 2 and 3 weeks after its administration, (ii) quality life score (FACT-G) 1, (iii) adverse events. If observed in eight patients or fewer, rejected. Results: Forty receiving pelvic radiotherapy were enrolled. Of...
Cell death is of two types; necrosis and apoptosis. In histiocytic necrotising lymphadenitis (HNL), apoptosis the main form cell death. Apoptosis results in formation nuclear debris, which one characteristic features HNL. We previously reported that HNL it predominantly CD8-positive cytotoxic T cells undergo apoptosis; however, majority proliferating are also cells. Recent advances technical analytical methods have facilitated parallel quantitation expression numerous genes using DNA...