A5078778979- Osteoarthritis Treatment and Mechanisms
- S100 Proteins and Annexins
- Inflammatory mediators and NSAID effects
- Adipose Tissue and Metabolism
- Alkaline Phosphatase Research Studies
- Peroxisome Proliferator-Activated Receptors
- Bone Metabolism and Diseases
- Milk Quality and Mastitis in Dairy Cows
- Cytokine Signaling Pathways and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Selenium in Biological Systems
- Fibroblast Growth Factor Research
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
- Infant Nutrition and Health
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- vaccines and immunoinformatics approaches
- Proteoglycans and glycosaminoglycans research
- Clinical Nutrition and Gastroenterology
- Neurotransmitter Receptor Influence on Behavior
- Galectins and Cancer Biology
- Neurogenetic and Muscular Disorders Research
New York University
2013-2018
Tohoku University
2004-2016
New York University Langone Orthopedic Hospital
2010-2014
Orthopaedic Research Society
2013
Io Therapeutics (United States)
2013
There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and other periphery. 5-HT affects feeding behavior obesity system. On hand, peripheral also may play an important role obesity, as it has been reported that regulates glucose lipid metabolism. Here we show intraperitoneal injection to mice inhibits weight gain, hyperglycemia insulin resistance completely prevented enlargement intra-abdominal adipocytes without having any effect on food...
Abstract The progressive ankylosis gene (ank) encodes a transmembrane protein that transports intracellular inorganic pyrophosphate (PPi) to the extracellular milieu. ank/ank mice, which express truncated nonfunctional ANK, showed markedly reduced bone mass, bone-formation rate, and number of tartrate-resistant acid phosphatase–positive (TRAP+) multinucleated osteoclasts. ANK function deficiency suppressed osteoblastic differentiation marrow stromal cells, as indicated by decrease in...
ANXA6, the gene for annexin A6, is highly expressed in osteoarthritic (OA) articular chondrocytes but not healthy chondrocytes. This study was undertaken to determine whether A6 affects catabolic events these cells.Articular were isolated from Anxa6-knockout mice, wild-type (WT) and human cartilage which ANXA6 overexpressed. Cells treated with interleukin-1β (IL-1β) or tumor necrosis factor α (TNFα), expression of genes activation NF-κB determined by real-time polymerase chain reaction...
Objective To determine the actions of lithium chloride (LiCl) on catabolic events in human articular chondrocytes, and effects LiCl progression severity cartilage degradation interleukin‐1β (IL‐1β)–treated mouse knee joints after surgical induction osteoarthritis (OA) a model. Methods Human chondrocytes were treated with followed by IL‐1β, expression levels genes determined real‐time polymerase chain reaction. understand mechanism which affects IL‐1β treatment, activation NF‐κB was using...
Annexin A6 (AnxA6) is highly expressed in hypertrophic and terminally differentiated growth plate chondrocytes. Rib chondrocytes isolated from newborn AnxA6-/- mice showed delayed terminal differentiation as indicated by reduced markers, including alkaline phosphatase, matrix metalloproteases-13, osteocalcin, runx2, mineralization. Lack of AnxA6 led to a decreased intracellular Ca(2+) concentration protein kinase C α (PKCα) activity, ultimately resulting extracellular signal-regulated (ERK)...
Osteoarthritis (OA) results from degenerative and abnormal function of joints, with localized biochemistry playing a critical role in its onset progression. As high levels all-trans retinoic acid (ATRA) synovial fluid have been identified as contributive factor to OA, the synthesis de novo antagonists for receptors (RARs) has exploited interrupt mechanism ATRA action. BMS493, pan-RAR inverse agonist, reported an effective inhibitor signaling pathway; however, it is unstable rapidly degrades...
Annexin A6 (AnxA6) is expressed in articular chondrocytes at levels higher than other mesenchymal cell types. However, the role of AnxA6 not known. Here we show that complete lack functions resulted increased ß-catenin activation Wnt3a-treated murine chondrocytes, whereas expressing showed decreased activation. High expression human highest inhibition Wnt/ß-catenin signaling. Inhibition signaling activity by together with cytosolic Ca2+ was achieved interfering plasma membrane association...
Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 27 million Americans.1 The lack current treatments to slow OA progression due both early detection methods and therapeutic targets for OA. Thus, there urgent need discovery potential new treatment Annexins are cytoplasmic proteins that, in presence Ca2+, translocate bind membranes. role annexins disease pathology emerging field investigation, with many studies highlighting not only as prognostic diagnostic...
To isolate candidate genes involved in bovine adipocyte differentiation, we have constructed a subtraction library from clonal intramuscular preadipocyte (BIP) cell line using PCRsubtraction.We isolated set of subtracted cDNA fragments whose respective mRNA levels are up regulated during adipogenesis.Two clones were determined to be type XII collagen alpha-1.From the expression analysis collagen, XIIA-2 isoform was mainly expressed differentiated BIP cells and adipose tissues.These results...