A5000686672- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Ear and Head Tumors
- Lung Cancer Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Endometrial and Cervical Cancer Treatments
- Vector-Borne Animal Diseases
- Chemokine receptors and signaling
- Bone Tumor Diagnosis and Treatments
- Animal Disease Management and Epidemiology
SAGA Heavy Ion Medical Accelerator in Tosu
2015-2024
Kurume University
2005-2023
Fukuoka University
2002-2005
Nagasaki University
2003
PurposeTo evaluate the efficacy and safety of carbon-ion radiation therapy (RT) for mucosal melanoma head neck (MMHN) in Japan Carbon-Ion Radiation Oncology Study Group study.Methods MaterialsPatients with MMHN N0-1M0 status who were treated RT at 4 institutions between November 2003 December 2014 analyzed retrospectively. Two hundred sixty patients (male, 111; female, 149; median age, 68 years) histologically proven enrolled.ResultsPrimary sites included nasal cavity 178 patients, paranasal...
Background Adult T-cell leukaemia/lymphoma (ATLL) is a human malignancy associated with leukaemia virus type I (HTLV-I). ATLL frequently involves the skin. Objectives To correlate clinicopathological features and prognosis in patients cutaneous lesions. Methods We examined HTLV-I proviral state of lesions 80 serum anti-ATL antibody, to clarify correlation between macroscopic/histopathological findings prognosis. Southern blot analysis was performed all cases detect monoclonal DNA...
To evaluate the safety and efficacy of carbon-ion radiation therapy (C-ion RT) for locally advanced sinonasal malignant tumors in a multicenter retrospective study (J-CROS 1402 HN).Clinical data were collected patients who had stage N0-1M0 received C-ion RT at 4 institutions Japan between November 2003 December 2014. Of 458 patients, 393 naïve 65 recurrent tumors. The located nasal cavity (n = 263), maxillary sinus 109), ethmoid 71), other locations 15). histologic types mucosal melanoma...
A retrospective multicenter study was carried out to assess the clinical outcomes of carbon‐ion radiotherapy for head and neck malignancies (Japan Carbon‐Ion Radiation Oncology Study Group [J‐ CROS ] study: 1402 HN ). We evaluated safety efficacy in patients with major salivary gland carcinoma. Sixty‐nine treated at four Japanese institutions were analyzed. Thirty‐three (48%) had adenoid cystic carcinomas, 10 (14%) mucoepidermoid 26 (38%) other disease types. Three (4%) T1 disease, 8 (12%)...
Radiotherapy is a standard treatment for inoperable stage I non-small cell lung cancer (NSCLC), and carbon-ion radiation therapy (CIRT) may be used such treatment. Although CIRT NSCLC has demonstrated favorable outcomes in previous reports, the reports covered only single-institution studies. We conducted prospective nationwide registry study including all institutions Japan.Ninety-five patients with were treated by between May 2016 June 2018. The dose fractionations selected from several...
Abstract Anti-cancer treatments for lung cancer patients with interstitial disease (ILD) are challenging. The treatment options ILD often limited because of concerns that can cause acute exacerbation (AE) ILD. This study aimed to analyze the outcomes carbon-ion radiotherapy (CIRT) stage I non-small cell (NSCLC) ILD, using a multi-institutional registry. Patients who received CIRT NSCLC in institutions Japan were enrolled. indication was determined by an institutional multidisciplinary tumor...
WHO classification for malignant lymphoma was recently proposed. However, PTCL is heterogeneous. Chemokines and its receptors are closely associated with the T-cell subtypes. To clarify subtype in PTCL, we conducted DNA chips of chemokine, receptor (R) cytokines. Angioimmunoblastic (AILD, n=4), anaplastic large cell (ALCL, adult leukemia (ATLL, n=7), NK-cell (NKL, n=2) unspecified (PTCL-U, n=6) were analyzed using chips. In addition, immunological stainings performed 280 cases. chip, AILD,...
This study aimed to evaluate the clinical outcomes of patients with mucoepidermoid carcinomas in head and neck treated carbon-ion radiotherapy. Data from 26 who underwent radiotherapy four facilities were analyzed this multi-institutional retrospective study: Japan Carbon-ion Radiation Oncology Study Group. The median follow-up time was 34 months. One patient experienced local recurrence, 3-year control rate 95%. developed lymph node recurrence five distant metastases. progression-free...
The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study a sub-analysis the Japan Carbon-Ion Radiation Oncology Study Group (1402 HN, UMIN000024473). Clinical data T4 ONBs treated C-ion RT at four Institutions between November 2003 December 2014 were retrospectively reviewed. Twenty-one underwent RT. Seven had T4a 14 T4b tumours without cervical node metastases. median follow-up period...
Introduction: The standard therapy for stage I non-small cell lung cancer (NSCLC) is surgery, but some operable patients refuse this option and instead undergo radiotherapy.Carbon-ion radiotherapy (CIRT) a type of radiotherapy.The Japanese prospective nationwide registry study on CIRT began in 2016.Here, we analyzed real-world clinical outcomes with NSCLC.Methods: All NSCLC treated Japan between 2016 2018 were enrolled.The dose fractionations selected from several options approved by the...
Abstract Chemokine receptors mediate the migration of lymphocytes through binding their ligands. CXCR3 is expressed in Th1 T cells; however, was recently reported B‐cell mucosa‐associated lymphoid tissue (MALT)‐type lymphoma and splenic marginal zone lymphoma. To investigate whether CXCR3‐positive B peripheral blood (PB) migrate to MALT spleen, clone present PB, we studied 16 cases In cases, PB could MIG, ligand. Immunohistochemical analysis showed that cells CXCR3, whereas epithelial glands...
We investigated the interobserver variation in prostate target volume and trend toward use of diagnostic computed tomography (CT) or magnetic resonance (MR) images for treatment planning. Twenty-five radiation oncologists were asked to draw external contour on CT (0.3 cm spacing) a patient with localized cancer. They also answered questionnaire regarding MR contouring. Of 25 physicians, 28% rarely never referred images. In contrast, physicians tended refer more frequently. Approximately 50%...
We studied the morphologic, immunohistochemical, and clinical characteristics of 158 cases lymphoblastic lymphoma. Based on immunophenotyping cell lineage, were classified into B-cell type (CD20,CD19 or CD79a+, n = 53), T-cell (surface CD3+, 84), non-B, non-T (B marker- surface CD3-, 21). The latter group was further divided based immunohistochemistry into: 1) CD7+ stem lymphoma (CD7+SCL) [CD4-, CD7+, CD33+/-, CD56-], 2) blastic natural killer (B-NKL) CD7+/-, CD33-, CD56+, CD123-], 3)...
Abstract Background This multi‐institutional retrospective study focused on the clinical outcome of carbon‐ion radiotherapy (C‐ion RT) for non‐squamous cell malignant tumors nasopharynx. Methods The Japan Carbon‐ion Radiation Oncology Study Group collected and analyzed data 43 patients with nasopharynx treated C‐ion RT at four institutions in Japan. Results Twenty‐nine had adenoid cystic carcinomas, seven melanomas, three adenocarcinomas, two mucoepidermoid other pathologies. Twenty‐six...
Chemokine receptors mediate the migration of lymphocytes through binding ligands, and expression is differentially regulated in lymphocyte subsets. CXCR3 usually expressed Th1 T cells, however, recently reported to be B cell chronic lymphocytic leukemia, mucosa-associated lymphoid tissue type lymphoma (MALT) (extranodal marginal zone lymphoma), other non-Hodgkin lymphomas. Our study was designed investigate its ligand Mig, their relationships MALT using immunohistochemistry. In addition,...
Abstract Background The aim of this study was to evaluate the efficacy and safety carbon‐ion radiation therapy for nonsquamous cell carcinomas oral cavity in a multicenter study. Methods Retrospective analysis clinicopathological features outcomes 76 patients with N0‐1 M0 status were treated at four institutions Japan between November 2003 December 2014 performed. Results Salivary gland carcinoma, mucosal melanoma, three other found 46, 27, 3 patients, respectively. T1‐3, T4a, T4b disease...
Abstract Classical Hodgkin lymphoma (HL) is characterized by the presence of and Reed‐Sternberg cells (H&RS) a prominent lymphocytic infiltration. We previously reported Hodgkin‐like adult T‐cell leukemia/lymphoma (HL‐like ATLL) (new WHO classification). Various CXC CC chemokines are expressed on H&RS relationships between chemokine receptor (R) thought to be important for selectivity local immunity Th1 Th2 T cells. To clarify role in classical HL ATLL, we performed gene expression...