A5071620699- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Cardiac Arrhythmias and Treatments
- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Chemotherapy-induced cardiotoxicity and mitigation
- Metabolism, Diabetes, and Cancer
- Eosinophilic Disorders and Syndromes
- Cardiac pacing and defibrillation studies
- Potassium and Related Disorders
- Pancreatic function and diabetes
- HER2/EGFR in Cancer Research
- Venous Thromboembolism Diagnosis and Management
- Sarcoidosis and Beryllium Toxicity Research
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Treatment and Pharmacology
- Thermoregulation and physiological responses
- Frailty in Older Adults
- Vasculitis and related conditions
- Cardiac Fibrosis and Remodeling
- Aortic aneurysm repair treatments
Niigata University
2014-2024
Niigata University Medical and Dental Hospital
2022-2024
Municipal Tsuruga Hospital
2022
Cardiovascular Research Center
2021
Nippon Shinyaku (Japan)
2019
Shizuoka University
2004
Abstract It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and elimination (senolysis) improves age-associated pathologies. Here, we demonstrate inhibition sodium–glucose co-transporter 2 (SGLT2) enhances clearance cells, thereby ameliorating phenotypic changes. In a mouse model dietary obesity, short-term treatment with the SGLT2 inhibitor canagliflozin reduced senescence load visceral adipose tissue improved inflammation...
Abstract Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and cardiovascular death with type diabetes; however, their effect on arrhythmias is unclear. The purpose this study was to investigate effects empagliflozin ventricular in patients diabetes. Methods A total 150 diabetes who were treated an implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator (ICD/CRT-D) randomized once-daily placebo...
Abstract Background Trastuzumab has improved breast cancer (BC) prognosis and reduced anthracycline use. However, the characteristic changes of anthracycline-related cardiomyopathy (ARCM) in patients with BC remain unclear. We aimed to update our understanding ARCM trastuzumab era. METHODS This retrospective observational cohort study included 2959 treated anthracyclines at three regional centers Niigata City between 1990 2020. Seventy-five (2.5%) developed were categorized into two groups:...
Vascular Ehlers-Danlos syndrome (vEDS) is a hereditary connective tissue disorder (HCTD) characterized by arterial dissection/aneurysm/rupture, sigmoid colon rupture, or uterine rupture. Diagnosis confirmed detecting heterozygous variants in COL3A1. This the largest Asian case series and first to apply an amplification-based next-generation sequencing through custom panels of causative genes for HCTDs, including specific method evaluating copy number variations. Among 429 patients with...
Background: Although guideline-directed medical therapy (GDMT), including β-blockers, angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARBs), and mineralocorticoid antagonists (MRAs), improves survival quality of life, most patients with heart failure reduced (HFrEF) mildly (HFmrEF) ejection fraction are treated inadequate medications. We investigated the prescription patterns GDMT in elderly HFrEF HFmrEF their characteristics, certification long-term care...
Brown adipose tissue (BAT) has a role in maintaining systemic metabolic health rodents and humans. Here, we show that stress induces BAT to produce coagulation factors, which then—together with molecules derived from the circulation—promote dysfunction glucose intolerance. When mice were fed high-fat diet (HFD), levels of factor, Factor VII (FVII), activated X (FXa), protease-activated receptor 1 (PAR1) expression increased significantly BAT. Genetic or pharmacological suppression...
Type 2 diabetes (T2DM) is associated with cardiovascular death, including sudden cardiac death due to arrhythmias. Patients an implantable cardioverter-defibrillator (ICD) are also at high risk of developing a clinically significant ventricular arrhythmia. It has been reported that sodium–glucose cotransporter (SGLT2) inhibitors can reduce deaths; however, the physiological mechanisms this remain unclear. is, well known SGLT2 increase blood ketone bodies, which have suggested...
Heart failure in elderly people causes physical and cognitive dysfunction often requires long-term care insurance (LTCI); however, among patients with left ventricular (LV) systolic dysfunction, the incidence risk factors of future LTCI requirements need to be elucidated.
Immunosuppressive therapy with prednisolone (PSL) is the first-line treatment for cardiac sarcoidosis (CS), and 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) used to evaluate its efficacy guide treatment. However, appropriate timing of FDG-PET in CS remains unknown. This single-center, retrospective, observational study included 15 consecutive patients who underwent 3 serial scans (at baseline, early phase [1-2 months after PSL introduction], late [≥ 5 introduction a...
<title>Abstract</title> BACKGROUND Trastuzumab has improved breast cancer (BC) prognosis and reduced anthracycline use. However, the characteristic changes of anthracycline-related cardiomyopathy (ARCM) in patients with BC remain unclear. We sought to update our knowledge ARCM trastuzumab era. METHODS This was a retrospective observational cohort study. A total 2,959 treated anthracyclines three regional centers Niigata City between 1990 2020 were included. Seventy-five (2.5%) developed...
The ONCO DVT study demonstrated potential benefits of extended edoxaban treatment in patients with isolated distal deep vein thrombosis terms thrombotic risk. However, the risk-benefit balance anemia remains unclear.
Brown adipose tissue (BAT) plays an important role in energy metabolism because it uses fatty acids for thermogenesis during cold exposure. Preclinical studies found that boysenberry anthocyanins (BoyACs) activate BAT. Therefore, the aim of this preliminary study was to evaluate how BoyAC intake affects BAT humans. We performed open-label single-arm nonrandomized healthy volunteers. Before and after 4 weeks daily consumption 100 ml juice (BoyJ) containing 61 mg BoyACs, participants were...
ABSTRACT Background Cell-free eosinophil granules, which are considered harmful to the heart, stained red by haematoxylin-eosin (HE); however, they can be overlooked in cardiac tissue due reddish staining of cardiomyocytes and fibres. Direct fast scarlet (DFS) Congo (CR), known for amyloid deposits, stain granules; no firm evidence currently exists. This study aimed confirm that DFS CR granules evaluate their advantages over HE. Methods Paraffin-embedded endomyocardial biopsy samples from...
Since permanent inferior vena cava (IVC) filters increase deep vein thrombosis (DVT), filter retrieval should be performed as possible. Despite the guideline recommendation, IVC are not always retrieved in clinical practice. To date, many patients with not-retrieval have been prescribed anticoagulant therapy, but long-term prognosis, including venous thromboembolism (VTE) and bleeding events, remains unknown. In this study, 195 who underwent implantation between 2006 2017 at 3 institutions...
Background Frailty is a multifactorial physiological syndrome most often associated with age but which has received increasing recognition as component of chronic illnesses such heart failure. Patients failure are likely to be frail, irrespective their age. Adipokine dysregulation, frailty, occurs in patients In this study, we tested the hypothesis that adipokines frailty Methods Thirty-five (age, 67 ± 14 years; 25 males; left ventricular ejection fraction, 45 19%) were included. Serum...
The left ventricular contractile force (LV dP/dtmax) of patients with systolic dysfunction does not increase effectively an in heart rate. In other words, their force-frequency relationship (FFR) is impaired. However, it unknown whether a longer coupling interval subsequent to tachycardia causes stronger contraction (poststimulation potentiation, PSP) rate-dependent manner.In 16 idiopathic dilated cardiomyopathy (DCM) (48 ± 2 years old, LVEF 30 10%) and 6 control (58 4 70 7%), FFR was...
Abstract Background The coagulation response during vascular injury with uninterrupted administration of direct oral anticoagulants (DOACs) has not been elucidated. Our aim was to evaluate differences in responses after between thrombin inhibitor and factor Xa recipients. Methods Patients scheduled for catheter ablation atrial fibrillation were randomly assigned receive dabigatran or apixaban this prospective, randomized, comparative, parallel-group study. Venous blood collected three times:...