A5019755265- Microfluidic and Bio-sensing Technologies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Microfluidic and Capillary Electrophoresis Applications
- Ion channel regulation and function
- Force Microscopy Techniques and Applications
- ECG Monitoring and Analysis
- Neuroscience and Neural Engineering
- Mechanical and Optical Resonators
- Polymer composites and self-healing
- Cardiovascular Function and Risk Factors
- Acoustic Wave Resonator Technologies
- Nanopore and Nanochannel Transport Studies
- Advanced MEMS and NEMS Technologies
- Lipid Membrane Structure and Behavior
- Advanced Sensor and Energy Harvesting Materials
- Retinal and Macular Surgery
- Orthopedic Surgery and Rehabilitation
- Intraocular Surgery and Lenses
- Micro and Nano Robotics
- Electrohydrodynamics and Fluid Dynamics
The University of Tokyo
2020-2024
Nagara Medical Center
2013-2024
Nagoya University
2014-2024
Kanagawa Institute of Technology
2021-2023
Japanese Red Cross Nagoya Daiichi Hospital
2016-2018
The Nakamura Hajime Eastern Institute
2016
Osaka University
2015
Niigata University
2003-2006
Yamagata University
1982
A highly sensitive odorant sensor was developed by using insect olfactory receptors reconstituted into a lipid bilayer membrane.
Cardiac sarcoidosis is increasingly recognized and associated with poor prognosis. Ventricular tachycardia (VT) cardiac the most likely cause of sudden death in patients, but mechanism has not been well established.This study investigated mechanisms outcome VT sarcoidosis.The included eight consecutive patients (five men, three women, aged 54 +/- 19 years) who had sustained monomorphic our hospital.The average ejection fraction was 43 11%. Twenty-two VTs were observed these mean heart rate...
We propose a method to characterize the mechanical properties of cells using robot-integrated microfluidic chip (robochip) and microscopy. The is designed apply specified deformations single detached cell an on-chip actuator probe. reaction force simultaneously measured sensor composed hollow folded beam probe structure. In order measure cellular characteristics in further detail, sub-pixel level resolution position required. Therefore, we utilize phase detection moiré fringe. Using this...
In patients with Brugada syndrome, implantable cardioverter defibrillator (ICD) is the only reliable treatment to prevent sudden death though, in some cases, internal defibrillation may be unsuccessful. The aim of this study was examine determinants failure, a focus on electrophysiologic characteristics.The included 51 treated ICD: 22 syndrome and 29 structural heart disease (SHD). prevalence energy requirement precluding programming 10-J safety margin, mean right ventricular effective...
Electrical abnormalities in the RVOT may be involved Brugada syndrome.We investigated relationship between signal-averaged ECG (SAECG) and electrophysiologic study (EPS), especially focusing on conduction delay outflow tract of right ventricle (RVOT) its contribution to clinical characteristics.Twenty-four patients with syndrome (23 men 1 woman; 61 +/- 16 years old) were studied. We assessed presence late potential (LP) SAECG filtered QRS duration precordial leads (V1 or V2; RfQRS) left (V5...
Background Some patients with an implantable cardioverter-defibrillator (ICD) suffer from burst of inappropriate multiple discharges (severe electrical storm), and because the current therapeutic options are limited, effect nifekalant hydrochloride, a new class III drug, on severe storm was investigated in present study. Methods Results Ninety-one consecutive treated ICD were included study (M 70; mean age 58 years; left ventricular ejection fraction 45±15%). Severe defined as more than 10...
Loading individual oocytes is a critical step for injecting RNA, expressing heterologous proteins, performing electrophysiological measurements, and so on. However, existing methods remain challenge automatically loading multiple single into different locations. Herein, novel microfluidic chip on robotic manipulator (chip‐on‐robot) with feedback control flexible manipulation of within large spatial range proposed. The controls the to reach locations based imaging feedback. then utilizes...
This paper reports a method to measure the mechanical properties of single cell using microfluidic chip with integrated force sensing and liquid exchange function. A is manipulated positioned between pushing probe sensor optical tweezers. These two on-chip probes were designed capture deform cells. The deformed by moving probe, which driven an external force. liquid–liquid interface formed laminar flow change extracellular environment. position shifted controlling injection pressure. Two...
Objective The association between natriuretic peptide levels in atrial fibrillation (AF) patients with advanced left (LA) remodeling and reverse after rhythm control therapy has not been clarified. present study assessed the role of (ANP) brain (BNP) measurements to predict LA catheter ablation (CA) persistent AF enlargement.
The integration of liquid exchange and microfluidic chips plays a critical role in the biomedical biophysical fields as it enables control extracellular environment allows for simultaneous stimulation detection single cells. In this study, we present novel approach measuring transient response cells using system integrated with chip probe dual pump. was composed pump system, chip, optical tweezers, an external manipulator, piezo actuator, etc. Particularly, incorporated to allow high-speed...
Quinidine, a class I antiarrhythmic agent with blocking property of transient outward current, is possible candidate for the suppression ventricular fibrillation in patients Brugada syndrome; although there concern that its ability to these effects may be proarrhythmic. Therefore, we evaluated effect quinidine sulfate on ST-segment elevation syndrome. In 8 syndrome, magnitude ST-elevation at J-point (ST(J)), and configuration leads V1-V3, were compared before day 2 after initiation...
Robot-integrated microfluidic chip is a promising tool to realize mechanical characterization of single cell with high throughput and accuracy. The used in our system has pair microprobes measure deformation reaction force cells. In previous studies, we measured the elasticity cells this measurement system. However, there were some problems on method limited small regions cell. To avoid these problems, changed utilize large First, proposed differential-type sampling moiré extend range or...
Medial condyle fracture of the humerus is extremely rare in pediatric elbow fractures. We report a case malunion medial 10-year-old boy who had an injury on right at age 4. He was referred to our clinic because severe varus deformity (the carrying angle 191°, unaffected side 172°) with instability. Extra-articular closing wedge osteotomy performed. Five years after surgery, 172° and patient no pain difficulties activities daily living.
The ventricular tachyarrhythmias associated with the LQT3 syndrome are typically bradycardia-dependent. However, some episodes can be exercise or emotional stress, suggesting a different arrhythmogenic mechanism when sympathetic activity predominates. This study examined potential mechanisms during periods of autonomically mediated transient heart rate acceleration in canine anthopleurin-A model syndrome. Using plunge needle electrodes, transmural unipolar electrograms left ventricle were...
Background: This study was performed to clarify the antiarrhythmic effects of magnesium sulfate (Mg ++ ) in a prolonged QT interval canine model polymorphic ventricular tachyarrhythmia (VTA). Methods: In six experiments by anthopleurin‐A, Mg administered boluses 0.2 mL/kg during repetitive episodes self‐terminating VTA or frequent premature complexes (PVCs). The distribution repolarization across left ventricular(LV) wall and dispersion transmural were analyzed before, 30 120 seconds after...
Disopyramide is thought to have an advantageous effect for atrial fibrillation (AF) associated with vagal activity because of its anticholinergic effect.We used a canine nerve stimulation (VNS) model. The monophasic action potential (MAP) duration at 90% repolarization (MAP(90)), the intraatrial conduction time, induciblity AF by electrical stimulation, and amplitude high-frequency component (HF-amp) heart rate variability (HRV) were evaluated before after administration disopyramide (1...
This paper proposes the method for mechanical characterization of floating cells on a microfluidic chip. We measured reactive force chip by applying deformation to cells. Particularly we focused improve sensing resolution probe position using phase detection moiré fringe. realized approximately ten times higher compared previous method. The detailed data suggest some unique characteristics discussed phenomenon seen with model, which is based Heltzian contact theory in light stiff nucleus.
The automation of the experimental process and evaluation method is required to screen chemical substances in fields biology chemistry. In case with biological evaluations, mechanical probing has been considered, but measurement should possess versatility as properties samples widely distribute. We present a stiffness using quartz crystal resonator (QCR) fabricated force sensor probe. Owing low frequency noise, QCR exhibits wide range. measured two samples, organoids polydimethylsiloxane...