A5026502348- Connective tissue disorders research
- Autoimmune Bullous Skin Diseases
- Drug-Induced Adverse Reactions
- Dermatological and Skeletal Disorders
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- Skin and Cellular Biology Research
- Polymer Surface Interaction Studies
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Skin Diseases and Diabetes
- Psoriasis: Treatment and Pathogenesis
- Genetic and rare skin diseases.
- Vascular Malformations and Hemangiomas
- Fungal Infections and Studies
- Herpesvirus Infections and Treatments
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Plant Pathogens and Fungal Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Cutaneous lymphoproliferative disorders research
- Molecular Junctions and Nanostructures
Dokkyo Medical University
2016-2025
University of Cologne
2016
Dokkyo University
2009-2011
Menicon (Japan)
2007
National Institute of Advanced Industrial Science and Technology
2001-2003
Nagoya Institute of Technology
2003
Tohoku University
2000-2002
Doshisha University
2002
Shimane University
1997
Kyushu University
1992
Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor functions by bridging different ECM structures. We have previously shown that COMP also a constitutive healthy human skin strongly induced fibrosis. binds directly with high affinity to collagen I XII decorates surface fibrils. demonstrate here lack COMP-collagen interaction space leads changes fibril morphology density,...
The Ehlers–Danlos Syndromes (EDS), a group of hereditary connective tissue disorders, were classified into 13 subtypes in the 2017 International Classification. Recently, new subtype EDS called classical-like type 2 (clEDS2), which is caused by biallelic variants adipocyte enhancer binding protein 1 ( AEBP1 ) gene, was identified. We describe 11th patient (9th family) with clEDS2, who complicated critical vascular event (superior mesenteric artery aneurysm and rupture). A next-generation...
Interactions between opposed brush layers of polyelectrolytes ionized poly(l-glutamic acid) (PLGA) or poly(l-lysine) (PLL) in water were directly investigated using surface forces measurement. The prepared by the Langmuir−Blodgett deposition amphiphiles bearing PLGA (degree polymerization n = 21, 44, and 48) PLL (n 41 52) as hydrophilic groups. density polyelectrolyte chains was around 0.4 chain/nm2. Surface force profiles, consisting a long-range electrical double layer repulsion...
Vascular-type Ehlers-Danlos syndrome (vEDS) is a severe autosomal dominant inherited disorder resulting from mutations within the α1 type III collagen gene (COL3A1). The majority of published are base changes leading to substitution single glycine residues triple-helical domain collagen. Although clinical characteristics and in COL3A1 have been analysed for some patients Europe America, similar analyses not yet performed Japanese with vEDS.To analyse genetic phenotypic findings vEDS.We...
Abstract Abnormalities in type I procollagen genes ( COL1A1 and COL1A2 ) are responsible for hereditary connective tissue disorders including osteogenesis imperfecta (OI), specific types of Ehlers‐Danlos syndrome (EDS), COL1‐ related overlapping disorder (C1ROD). C1ROD is a recently proposed characterized by predominant EDS symptoms joint skin laxity mild OI bone fragility blue sclera. Patients with do not carry variants COL1‐related EDS, classical, vascular, cardiac‐valvular, arthrochalasia...
Vascular Ehlers-Danlos syndrome (vEDS) is a hereditary connective tissue disorder (HCTD) characterized by arterial dissection/aneurysm/rupture, sigmoid colon rupture, or uterine rupture. Diagnosis confirmed detecting heterozygous variants in COL3A1. This the largest Asian case series and first to apply an amplification-based next-generation sequencing through custom panels of causative genes for HCTDs, including specific method evaluating copy number variations. Among 429 patients with...
Background: Vascular-type Ehlers-Danlos syndrome (vEDS) is caused by collagen III deficit resulting from heterogeneous mutations in COL3A1, which occasionally causes sudden death due to arterial/visceral rupture. However, it difficult conduct basic research on the pathophysiology of vEDS. Moreover, number patients with vEDS small, limiting available samples. Furthermore, symptoms may vary among family members, even if they share same mutation. Accordingly, many aspects pathology remain...
Neurocutaneous melanosis (NCM) is a rare condition characterized by central nervous system melanocytic tumors associated with congenital nevi. Phacomatosis pigmentovascularis (PPV) an association of vascular nevus pigmentary nevus. Aberrant maturation neural crest-derived cells considered to be related pathogenesis in both conditions. However, NCM and PPV has not been reported the best our knowledge. Melanocytoma, which usually involves leptomeninges or spinal cord, extremely...
Abstract Vascular‐type Ehlers–Danlos syndrome (vEDS) is an autosomal‐dominant inherited disorder caused by a deficit in collagen III. It results from heterogeneous mutations the α1 III gene ( COL3A1 ) and associated with life‐threatening complications, even younger patients. However, details of pathogenesis underlying mutation causing vEDS remain unclear. Here, we focus on anomalies fiber size endoplasmic reticulum (ER) stress response patients using electron microscopy (EM). We discovered...
A 39-year-old Japanese woman suffering from plaque stage of mycosis fungoides (MF) developed Kaposi's varicelliform eruption (KVE) on her face. KVE appeared 1 month after commencing skin electron beam irradiation (SEBI), when the total had reached 46 Gy. Natural killer (NK) cell activity in peripheral blood was abnormally low, but returned to normal year. However, lymphocyte reactivity mitogens persistently low. These facts suggested that our patient because low NK probably induced by...
Summary Background The gold standard for diagnosis of cutaneous sporotrichosis involves the isolation fungus, Sporothrix , by a culture test. Generally, sampling test is performed at same time as skin biopsy under local anaesthesia. However, may occasionally return false negative result. Objective aim our study was to investigate diagnostic value molecular method diagnosing from formalin‐fixed and paraffin‐embedded (FFPE) tissues. Methods Over 30‐year period, we collected 52 cases biopsied...