A5021233138- Systemic Sclerosis and Related Diseases
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Mast cells and histamine
- Advanced Biosensing Techniques and Applications
- TGF-β signaling in diseases
- Dupuytren's Contracture and Treatments
Miltenyi Biotec (Germany)
2024
University of Cologne
2016-2022
TGFB1 (transforming growth factor beta 1) is a potent cytokine playing driving role in development, fibrosis and cancer. It synthesized as prodomain-growth complex that requires tethering to LTBP (latent transforming binding protein) for efficient secretion into the extracellular space. Upon release, this large latent sequestered by anchorage matrix (ECM) networks, from which mature needs be activated order reach its receptors initiate signaling. Here, we uncovered novel intracellular...
Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor functions by bridging different ECM structures. We have previously shown that COMP also a constitutive healthy human skin strongly induced fibrosis. binds directly with high affinity to collagen I XII decorates surface fibrils. demonstrate here lack COMP-collagen interaction space leads changes fibril morphology density,...
Our skin is continuously exposed to mechanical challenge, including shear, stretch, and compression. The extracellular matrix of the dermis perfectly suited resist these challenges maintain integrity normal even upon large strains. Fibroblasts are key cells that interpret chemical cues in their environment turnover homeostasis healthy adults. Upon tissue injury, fibroblasts an exclusive selection other become activated into myofibroblasts with task restore by forming structurally imperfect...
Abstract Spatial biology is integral to understanding the dynamics of immune cells, tumor microenvironment (TME), and therapeutic responses in cancer research. Ultra-high-plex immunofluorescence has transformed deep phenotyping cell neighborhood analysis, providing unprecedented insight into complex heterogeneous samples such as TME. Many spatial platforms reduce operator hands-on time by automating image acquisition. However, determining most appropriate markers distinguish key types,...