A5039229256- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Advanced Radiotherapy Techniques
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Renal and related cancers
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Zebrafish Biomedical Research Applications
- Chronic Myeloid Leukemia Treatments
- Inflammatory Bowel Disease
- Hematopoietic Stem Cell Transplantation
- CRISPR and Genetic Engineering
- Chronic Lymphocytic Leukemia Research
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Advances in Oncology and Radiotherapy
- Cancer-related Molecular Pathways
- Parkinson's Disease Mechanisms and Treatments
- Microscopic Colitis
Hospital Clínic de Barcelona
2023-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2024
Centro de Biología Molecular Severo Ochoa
2016-2023
Universidad Autónoma de Madrid
2016-2023
Consejo Superior de Investigaciones Científicas
2016-2023
Universitat de Barcelona
2015-2022
KU Leuven
2019-2022
VIB-KU Leuven Center for Cancer Biology
2019-2022
Universitair Ziekenhuis Leuven
2020-2022
Resistance exercise (RE) improves neuromuscular function and physical performance after stroke. Yet, the effects of RE emphasizing eccentric (ECC; lengthening) actions on muscle hypertrophy cognitive in stroke patients are currently unknown. Thus, this study explored ECC-overload training skeletal size function, individuals with Thirty-two chronic (≥6 months post-stroke) were randomly assigned into a group (TG; n = 16) performing flywheel more-affected lower limb (12 weeks, 2 times/week; 4...
Modulating T cell activation is critical for treating autoimmune diseases but requires avoiding concomitant opportunistic infections. Antigen binding to the receptor (TCR) triggers recruitment of cytosolic adaptor protein Nck a proline-rich sequence in cytoplasmic tail TCR's CD3ε subunit. Through virtual screening and using combinatorial chemistry, we have generated an orally available, low-molecular weight inhibitor TCR-Nck interaction that selectively inhibits TCR-triggered with IC50...
The MLL-AF4 (MA4) fusion gene is the genetic hallmark of an aggressive infant pro-B-acute lymphoblastic leukemia (B-ALL). Our understanding MA4-mediated transformation very limited. Whole-genome sequencing studies revealed a silent mutational landscape, which contradicts clinical outcome this hematologic malignancy. Only RAS mutations were recurrently detected in patients and found to be associated with poorer outcome. absence MA4-driven B-ALL models further questions whether MA4 acts as...
Abstract Mixed-lineage leukemia (MLL)-rearranged (MLLr) infant B-cell acute lymphoblastic (iMLLr-B-ALL) has a dismal prognosis and is associated with pro-B/mixed phenotype, therapy refractoriness frequent central nervous system (CNS) disease/relapse. Neuron-glial antigen 2 (NG2) specifically expressed in MLLr leukemias used immunophenotyping because of its predictive value for leukemias. NG2 involved melanoma metastasis brain development; however, role MLL-mediated leukemogenesis remains...
In vertebrates, GATA2 is a master regulator of hematopoiesis and expressed throughout embryo development in adult life. Although the essential role mouse well established, its involvement during early human hematopoietic not clear. By combining time-controlled overexpression with genetic knockout experiments, we found that GATA2, at mesoderm specification stage, promotes generation hemogenic endothelial progenitors their further differentiation to progenitor cells, negatively regulates...
Abstract Purpose: KPT-8602 (Eltanexor) is a second-generation exportin-1 (XPO1) inhibitor with potent activity against acute lymphoblastic leukemia (ALL) in preclinical models and minimal effects on normal cells. In this study, we evaluated whether would synergize dexamethasone, vincristine, or doxorubicin, three drugs currently used for the treatment of ALL. Experimental Design: First, searched most synergistic combination doxorubicin vitro both B-ALL T-ALL cell lines using proliferation...
T cells form immunological synapses with professional antigen-presenting (APCs) resulting in cell activation and the acquisition of peptide antigen-MHC (pMHC) complexes from plasma membrane APC. They thus become APCs themselves. We investigate functional outcome T-T antigen presentation by CD4 find that (Tpres) predominantly differentiate into regulatory (Treg), whereas have been stimulated Tpres Th17 pro-inflammatory cells. Using mice deficient pMHC uptake cells, we show is important for...
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of hematological cancers arising from the malignant transformation mature T cells. In cohort 28 PTCL cases, we identified recurrent overexpression MYCN, member MYC family oncogenic transcription factors. Approximately half all cases was characterized by expression signature. Inducible MYCN in lymphoid cells mouse model caused that recapitulated human with an Integration and data EZH2 as key downstream target MYCN. Remarkably, found...
Coenzyme Q10 (CoQ10 ) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain (MRC) and is essential antioxidant. Mutations genes responsible for CoQ10 biosynthesis (COQ genes) cause primary deficiency, rare heterogeneous disorder with no clear genotype-phenotype association, mainly affecting tissues high-energy demand including brain skeletal muscle (SkM). Here, we report four-year-old girl diagnosed minor mental retardation lethal...
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, though it known to be essential for embryonic development, its role during adult life still poorly understood. Here we show that this lysine massively hyperacetylated peripheral neutrophils. Genome-wide mapping of H4K16ac terminally differentiated blood cells, along with functional experiments, supported histone post-translational modification the...
El uso de antidepresivos está muy extendido en la enfermedad Parkinson (EP), aunque existen pocos estudios calidad que aclaren su eficacia. La metodología para esta guía clínica se ha basado revisión literatura y opinión consenso del grupo trastornos movimiento AMN, recogida mediante una encuesta. Según evidencia científica, nortriptilina, venlafaxina, paroxetina o citalopram podrían ser utilizados el tratamiento depresión EP, con resultados contradictorios. Sin embargo, práctica clínica,...
// Cristina Prieto 1 , Rolf Marschalek 2 Alessa Kühn Adelheid Bursen Clara Bueno 1,3 and Pablo Menéndez 1,3,4 Department of Biomedicine, Josep Carreras Leukemia Research Institute, School Medicine, University Barcelona, Spain Institute Pharmaceutical Biology/DCAL, Goethe-University, Frankfurt, Germany 3 Centro de Investigación Biomédica en Red Cancer (CIBERONC), 4 Instituciò Catalana Recerca i Estudis Avançats, Correspondence to: Menéndez,...
Abstract Background T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% adult ALL cases. Over 70% T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway are predicted to be sensitive gamma-secretase inhibitors. We have recently demonstrated selective inhibition PSEN1-containing complexes can overcome dose-limiting toxicity associated with broad In this study, we developed combination treatment strategies...
Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard chemotherapy based on nucleoside analogs plus anthracyclines. The crosstalk between AML cells the BM stroma is a major mechanism underlying therapy resistance in AML. Lenalidomide pomalidomide, new generation immunomodulatory drugs (IMiDs), possess pleiotropic anti-leukemic properties including potent immune-modulating effects are commonly used hematological malignances...
Hematopoietic stem cell (HSC) engraftment has been achieved using single-cell transplantation of prospectively highly purified adult HSC populations. However, bulk transplants are still performed when assessing the potential early embryonic hematopoietic tissues such as aorta-gonad mesonephros (AGM) due to very low activity content in development. Intra-bone marrow (IBMT) emerged a superior administration route over intravenous (IV) for reconstituting ability human HSCs xenotransplant...
Aim: Epigenetic regulation plays an important role in cellular development and differentiation. A detailed map of the DNA methylation dynamics that occur during cell differentiation would contribute to decipher molecular networks governing fate commitment. Methods: Illumina MethylationEPIC BeadChip platform was used describe genome-wide changes observed throughout hematopoietic maturation by analyzing multiple myeloid lymphoid types. Results: We identified a plethora human T lymphocytes...
Although antidepressants are widely used in Parkinson's disease (PD), few well-designed studies to support their efficacy have been conducted. These clinical guidelines based on a review of the literature and results an AMN movement disorder study group survey. Evidence suggests that nortriptyline, venlafaxine, paroxetine, citalopram may be useful treating depression PD, although paroxetine yield conflicting results. In practice, however, selective serotonin reuptake inhibitors usually...