A5101884634- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Advanced Fiber Optic Sensors
- Photonic Crystal and Fiber Optics
- Photonic and Optical Devices
- Catalytic Cross-Coupling Reactions
- Electrospun Nanofibers in Biomedical Applications
- Phytochemistry and Biological Activities
- Advanced Fiber Laser Technologies
- Biological and pharmacological studies of plants
- biodegradable polymer synthesis and properties
- Plasmonic and Surface Plasmon Research
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Tissue Engineering and Regenerative Medicine
- Photochemistry and Electron Transfer Studies
- Analytical Chemistry and Sensors
- Mechanical Behavior of Composites
- Ginger and Zingiberaceae research
- Chemical Synthesis and Analysis
- Nonlinear Photonic Systems
- Genomics and Phylogenetic Studies
- Nonlinear Waves and Solitons
- Synthesis and Catalytic Reactions
Taizhou University
2023-2025
State Forestry and Grassland Administration
2024
Beijing University of Chinese Medicine
2023-2024
State Grid Corporation of China (China)
2023
ShanghaiTech University
2023
China University of Mining and Technology
2016-2022
University of California, Davis
2016-2022
University of California, Los Angeles
2022
East China Normal University
2019
Monash University
1995-2018
Abstract Reported herein is the unprecedented gold‐catalyzed formal [4+1]/[4+3] cycloadditions of diazo esters with hexahydro‐1,3,4‐triazines, thus providing five‐ and seven‐membered heterocycles in moderate to high yields under mild reaction conditions. These reactions feature use a gold complex accomplish diverse annulations first example involvement metallo‐enolcarbene cycloaddition. It also utilization stable triazines as dipolar adducts carbene‐involved cycloadditions. Mechanistic...
Abstract A gold(I)‐catalyzed cross‐coupling of diazo compounds to afford tetrasubstituted alkenes has been developed by taking advantage a trivial electronic difference between two substrates. N‐heterocyclic‐carbene‐derived gold complex is the most effective catalyst for this transformation. Based on new strategy, gold(I)‐initiated benzannulation achieved through tandem reaction involving cross‐coupling, 6π electrocyclization, and oxidative aromatization.
Abstract An unprecedented gold‐catalyzed ligand‐controlled cross‐coupling of diazo compounds by sequential selective denitrogenation and cyclization affords N‐substituted pyrazoles in a position‐switchable mode. This novel transformation features decomposition one moiety simultaneous preservation the other from two substrates. Notably, choice ancillary ligand to gold complex plays pivotal role on chemo‐ regioselectivity reactions.
A stereodivergent synthesis of five-membered N-heterocycles, such as 2,3-dihydropyrroles, and 2-methylene 3-methylene pyrrolidines, has been developed through a tandem annulation amino alkynes with diazo compounds involves the trapping in situ formed intermediates. Mechanistic investigations indicate that copper-catalyzed annulations proceed by allenoate formation subsequent intramolecular hydroamination. In contrast, rhodium-catalyzed protocol features carbenoid insertion into NH bond...
A gold-catalyzed sequential annulation reaction to prepare 3,4-fused bicyclic furan compounds has been realized by employing 2-(1-alkynyl)-2-alken-1-ones and 1,3,5-triazines as the starting materials under mild conditions. This protocol features multiple bond formation in a single operation with incorporation of two nitrogen carbon atoms into final products. mechanistic investigation reveals that annulations involved an unprecedented stepwise [3+2+2]-cycloaddition.
The first palladium-catalyzed asymmetric Heck reaction between aryl triflates and alkynes to give trisubstituted allenes with high er under mild conditions is described. key the success discovery fine-tuning of different N-substituents Xu-Phos, which ensure enantioselectivity reactivity. Synthetic transformation chiral chirality transfer was also demonstrated.
In this work, we developed a new antibody-targeted and redox-responsive drug delivery system "MSNs-CAIX" by binding the anti-carbonic anhydrase IX antibody (A-CAIX Ab) on surface of mesoporous silica nanoparticles (MSNs) via disulfide linkages. The design composite particles involved synthesis functionalization with thiol groups, 2,2'-dipyridyl CAIX antibody. vitro, capping doxorubicin hydrochloric (DOX)-loaded (DOX@MSNs-CAIX) exhibited effectively release in presence glutathione (GSH) owing...
We implement a BOTDR sensor that combines the complementary coding with fast Fourier transform (FFT) technique for high-performance distributed sensing. The employment of provides an enhanced signal-to-noise ratio sensing system, which leads to high accuracy measurement. Meanwhile, FFT in is combined reduce measurement time sharply compared classical frequency sweeping technique. In addition, pre-depletion two-wavelength probe pulse proposed suppress distortion induced by EDFA. Experiments...
Biomass is a direct reflection of community productivity, and the allocation aboveground belowground biomass survival strategy formed by long-term adaptation plants to environmental changes. However, under global changes, patterns aboveground–belowground allocations their controlling factors in different types grasslands are still unclear. Based on data 182 grasslands, including 17 alpine meadows (AMs) 21 desert steppes (DSs), this study investigates spatial distribution proportion (BGBP)...
We report an enhanced recognition and redox-responsive reversible host-guest system based on ester-bearing calix[n]phenoxazines. The carbonyl groups, oriented toward the cavity, act as extra binding sites to enhance affinity, which is confirmed by NMR FTIR experiments single-crystal structure analysis. Due oxidizable nature of calix[n]phenoxazine, a redox-controlled response established. This research not only provides strategy affinity in calix-like macrocyclic arenes but also marks major...
A challenging selective intermolecular cross-coupling and homocoupling of aryl–aryl or aryl–alkyl diazo compounds has been accomplished via a copper system, which afforded tetrasubstituted olefins in moderate to high yields with good excellent Z-selectivity. This novel methodology enables rapid synthesis olefins, would find broad application accessing maleimide libraries nature products bioactive small molecules.
Abstract Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants concern. Host proteases, TMPRSS2 CTSL/CTSB cleave spike play a crucial role in two alternative pathways viral entry are characterized as promising pharmacological targets. Here, we identify compounds that show potent inhibition these proteases determine their complex...
Abstract A gold(I)‐catalyzed cross‐coupling of diazo compounds to afford tetrasubstituted alkenes has been developed by taking advantage a trivial electronic difference between two substrates. N‐heterocyclic‐carbene‐derived gold complex is the most effective catalyst for this transformation. Based on new strategy, gold(I)‐initiated benzannulation achieved through tandem reaction involving cross‐coupling, 6π electrocyclization, and oxidative aromatization.
Abstract Reported herein is the unprecedented gold‐catalyzed formal [4+1]/[4+3] cycloadditions of diazo esters with hexahydro‐1,3,4‐triazines, thus providing five‐ and seven‐membered heterocycles in moderate to high yields under mild reaction conditions. These reactions feature use a gold complex accomplish diverse annulations first example involvement metallo‐enolcarbene cycloaddition. It also utilization stable triazines as dipolar adducts carbene‐involved cycloadditions. Mechanistic...
A cobalt-catalyzed C–N bond formation between aryl diazonium salts and vinyl diazoacetates has been developed under relatively mild conditions. The N-arylpyrazoles have prepared in moderate to high yields a regiospecific way.
Abstract A highly selective, controllable and synthetically useful base‐promoted intramolecular detosylative cyclization of bis‐ N ‐tosylhydrazones has been achieved, affording N‐containing heterocycles cyclic olefins under transition‐metal‐free or gold‐catalyzed procedures, respectively. Moreover, an effective practical metal‐free approach to synthesize polycyclic aromatic compounds is also reported.
Abstract An unprecedented gold‐catalyzed ligand‐controlled cross‐coupling of diazo compounds by sequential selective denitrogenation and cyclization affords N‐substituted pyrazoles in a position‐switchable mode. This novel transformation features decomposition one moiety simultaneous preservation the other from two substrates. Notably, choice ancillary ligand to gold complex plays pivotal role on chemo‐ regioselectivity reactions.