A5034406880- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Childhood Cancer Survivors' Quality of Life
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Antioxidant Activity and Oxidative Stress
- Acute Lymphoblastic Leukemia research
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Obesity, Physical Activity, Diet
- Folate and B Vitamins Research
- Hormonal and reproductive studies
- T-cell and B-cell Immunology
- Vitamin C and Antioxidants Research
- Nanoparticle-Based Drug Delivery
- Metabolism, Diabetes, and Cancer
- Intraperitoneal and Appendiceal Malignancies
- Epigenetics and DNA Methylation
- Lipid metabolism and disorders
- Occupational and environmental lung diseases
- Characterization and Applications of Magnetic Nanoparticles
Jagiellonian University
2019-2024
Collegium Medicum in Bydgoszcz
2021
The occurrence of childhood obesity is influenced by both genetic and epigenetic factors. FTO (FTO alpha-ketoglutarate dependent dioxygenase) a gene well-established connection with adiposity, while protooncogene PLAG1 (PLAG1 zinc finger) has been only recently linked to this condition. We performed cross-sectional study on cohort 16 obese (aged 6.6–17.7) 10 healthy 11.4–16.9) children. aim was evaluate the relationship between methylation expression aforementioned genes presence as well...
Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism genes encoding proteins engaged in folate metabolism pathway. aim current study to determine relationship between variants metabolism-related frequency toxicities HD-Mtx. Material Methods: A group 133 aged 1.5-18.1 years (median: 6.3) was treated accordance with ALL-IC-2002...
Adipokines and gastrointestinal tract hormones are important metabolic parameters, both epigenetic factors differential gene expression patterns may be associated with the alterations in their concentrations children. The function of FTO (FTO alpha-ketoglutarate dependent dioxygenase) regulation global rate is well described, whereas influence protooncogene PLAG1 (PLAG1 zinc finger) still not fully understood. A cross-sectional study on a group 26 children various BMI values (15.3-41.7;...
Patients who develop contrast-induced nephropathy (CIN) are at an increased short-term and long-term risk of adverse cardiovascular (CV) events. Our aim was to search for patient characteristics associated with changes in serum creatinine CIN incidence after each step two-stage coronary revascularization patients acute myocardial infarction (AMI) multivessel artery disease undergoing staged angioplasty during hospitalization AMI. We retrospectively analyzed medical records 138 without...
Metabolic disorders in children after hematopoietic stem cell transplantation (HSCT) are poorly characterized. However, it is known that dyslipidemia and insulin resistance particularly common these patients. We conducted a prospective study of 27 patients treated with HSCT to assess the possibility predicting abnormalities. measured gene expressions using microarray technique identify differences expression genes associated lipid metabolism before HSCT. In HSCT, total cholesterol levels...
Breast cancer (BC) is the most prevalent malignancy in women and researchers have strived to develop optimal strategies for its diagnosis management. Neoadjuvant chemotherapy (NAC), which reduces tumor size, risk of metastasis patient mortality, often also allows a de-escalation breast axillary surgery. Nonetheless, complete pathological response (pCR) achieved no more than 40% patients who underwent NAC. Dendritic cells (DCs) are professional antigen-presenting present microenvironment. The...
Background Breast cancer (BC) is the most commonly diagnosed malignant tumor in women. The disease and its subsequent treatment pose a serious burden on quality of life patients. Neoadjuvant chemotherapy (NAC) has become one crucial strategies for management BC. Since identification vitamin D receptor (VDR) mammary tissues, extensive mechanistic research been conducted function. expression VDR BC cells microenvironment could be new prognostic factor after NAC. Patients Methods This...
Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that generally indolent, however, could advance to invasive more than one-third cases if left untreated. Thus, there continuous research find DCIS characteristics would enable clinicians decide it be without intensive treatment. Neoductgenesis (i.e., formation the new duct improper morphology) promising, but still not sufficiently evaluated indicator future tumor invasiveness. We gathered data from 96 (histopathological,...
Ductal carcinoma in situ (DCIS) is the preinvasive form of breast cancer (BC). It disputed whether all cases DCIS require extensive treatment as overall risk progression to BC estimated at 40%. Therefore, crucial objective for researchers identify with significant transformation into BC. Dendritic cells (DC) are professional antigen presenting and such play a pivotal role formation immune that infiltrate tumors. The aim this study was investigate relationship between density DCs different...
Luminal A breast cancers are generally associated with low metastatic potential and good prognosis. However, there is a proportion of patients, who present metastases in lymph nodes. The aim our study was to determine the association between number positive nodes infiltrates tumor-associated cytotoxic CD8 + (CTLs), regulatory FOXP3 T cells (Tregs), as well other prognostic factors. Immunohistochemistry (IHC) for performed 87 formalin-fixed paraffin-embedded primary cancer tissues, cell...
Sudden cardiac arrest (SCA) is one of the most perilous complications acute myocardial infarction (AMI). For years, return spontaneous circulation (ROSC) has had to be achieved before patient could treated at catheterization laboratory, as simultaneous manual chest compression and angiography were mutually exclusive. Mechanical devices enabled resuscitation invasive percutaneous procedures. The aim was characterize poorer responders that would allow predict positive outcome such a treatment....
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Jaworek A, Łazarczyk Hałubiec P, Leończyk M, Staszewski F, Wojas-Pelc A. The history of pellagra. Dermatology Review/Przegląd Dermatologiczny. 2021;108(6):554-566. doi:10.5114/dr.2021.114610. APA Jaworek, A., Łazarczyk, Hałubiec, P., Leończyk, M., Staszewski, F., & Wojas-Pelc, (2021). Dermatologiczny, 108(6), 554-566. https://doi.org/10.5114/dr.2021.114610 Chicago Andrzej K., Agnieszka Przemysław Monika Filip...
Peritoneal mesothelioma is a rare neoplasm that associated with multiple diagnostic and therapeutic challenges. Therapeutic guidelines are scarce based on extrapolative data. Histopathological diagnosis difficult as neither the morphological finding nor immunohistochemical stains specific. The mainstay treatment for resectable disease cytoreductive surgery intraperitoneal chemotherapy being valuable addition. Treatment of non-resectable cases includes platinum-based chemotherapy, immune...
Hematopoietic stem cell transplantation (HSCT) is an effective treatment method used in many neoplastic and non-neoplastic diseases that affect the bone marrow, blood cells, immune system. The procedure associated with a risk of adverse events, mostly related to response after transplantation. aim our research was identify genes, processes cellular entities involved variety changes occurring allogeneic HSCT children by performing whole genome expression assessment together pathway enrichment...