A5054414656- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Antioxidant Activity and Oxidative Stress
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Thyroid Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Cancer, Hypoxia, and Metabolism
- Birth, Development, and Health
- Eosinophilic Disorders and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- MicroRNA in disease regulation
Jagiellonian University
2016-2024
The occurrence of childhood obesity is influenced by both genetic and epigenetic factors. FTO (FTO alpha-ketoglutarate dependent dioxygenase) a gene well-established connection with adiposity, while protooncogene PLAG1 (PLAG1 zinc finger) has been only recently linked to this condition. We performed cross-sectional study on cohort 16 obese (aged 6.6–17.7) 10 healthy 11.4–16.9) children. aim was evaluate the relationship between methylation expression aforementioned genes presence as well...
Prostate cancer (PCa) is the most common malignancy in men. Although prognosis early stages good, treatment of advanced PCa remains a formidable challenge. Even after an initial response to hormone therapy or chemotherapy, recurrences are frequent and resistance any systemic common. β-Carotene (BC), plant-derived tetraterpene, known for its antioxidant capacity can modulate multiple cellular signaling pathways, potentially affecting androgen synthesis. We investigated influence BC (dissolved...
The main focus of the Genetic Analysis Workshop 19 (GAW19) is identification genes related to occurrence hypertension in cohort patients with type 2 diabetes mellitus (T2DM). aim our study was predict dynamics future incidence, based on gene expression profiles, systolic and diastolic blood pressure changes time, sex, baseline age, cigarette smoking status. We analyzed data made available GAW19 participants, which included profiles peripheral mononuclear cells (PBMCs) from diabetic members...
Endometrial cancer (EC) is treated according to the stage and prognostic risk factors. Most EC patients are in early stages they surgically. However some of them, including those with high grade (grade 3) intermediate groups may require adjuvant therapy. The goal study was find differences between grades based on an miRNA gene expression profile. Tumor samples from 24 1 (n = 10), 2 7), 3 7) were subjected profiling using next generation sequencing. results obtained validated profile 407...
Approximately 10% of thyroid nodules undergoing fine needle aspiration biopsy (FNAB) receive a suspicious for follicular neoplasm (SFN) classification. Currently, there is no diagnostic tool to preoperatively discriminate between adenoma (FA) and cancer (TC), most patients require surgery exclude malignancy.To characterize the micro-ribonucleic acid (miRNA) signature tumors assessed as SFN define circulating miRNA patterns distinguish FA from in with biopsied using FNAB.The study included...
Abstract Intratumor heterogeneity (ITH) results from accumulation of somatic mutations in the fractions successive cancer cell generations. We aimed to use deep sequencing investigate ITH colorectal tumors with particular emphasis on variants oncogenes (ONC) and tumor suppressor genes (TSG). Samples were collected 16 patients negative or positive lymph node status ( n = 8 each). deep‐sequenced a panel 56 cancer‐related central peripheral locations T3 size primary healthy mucosa. The region...
AMA Wątor G, Kołton-Wróż M, Wołkow P, et al. No differences in miRNA expression the stroma of ERG+ and ERG– prostate cancers. Polish Journal Pathology. 2024:272-277. doi:10.5114/pjp.2023.134304. APA Wątor, G., Kołton-Wróż, M., Wołkow, P., Bełch, Ł., Chłosta, & Szpor, J. (2024). Pathology, 272-277. https://doi.org/10.5114/pjp.2023.134304 Chicago Gracjan, Maria Paweł Łukasz Piotr Joanna Agnieszka Klimkowska 2024. "No cancers". Pathology: Harvard J., Klimkowska, A., Nejman, K., Józkowicz,...