A5038624020- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- Telomeres, Telomerase, and Senescence
- Pluripotent Stem Cells Research
- Viral Infectious Diseases and Gene Expression in Insects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Xenotransplantation and immune response
- Lymphatic System and Diseases
- Colorectal Cancer Treatments and Studies
- Memory and Neural Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Renal and related cancers
- Genetic Mapping and Diversity in Plants and Animals
- Birth, Development, and Health
- Cancer Genomics and Diagnostics
- Genetics, Aging, and Longevity in Model Organisms
- Genetic factors in colorectal cancer
- Sperm and Testicular Function
- Neural dynamics and brain function
University of Helsinki
2019
Jagiellonian University
2014-2019
Czech Academy of Sciences
2017
Czech Academy of Sciences, Institute of Physiology
2017
University of Freiburg
2014
Institute of Animal Science
2007-2012
The mechanisms that regulate the strength of synaptic transmission and intrinsic neuronal excitability are well characterized; however, promote disease-causing neural network dysfunction poorly defined. We generated mice with targeted neuron type–specific expression a gain-of-function variant neurotransmitter receptor for glycine (GlyR) is found in hippocampectomies from patients temporal lobe epilepsy. In this mouse model, GlyR terminals glutamatergic cells or parvalbumin-positive...
Vascular endothelial growth factor-C (VEGF-C) acts primarily on cells, but also non-vascular targets, for example in the CNS and immune system. Here we describe a novel, unique VEGF-C form human reproductive system produced via cleavage by kallikrein-related peptidase 3 (KLK3), aka prostate-specific antigen (PSA). KLK3 activated specifically efficiently through at novel N-terminal site. We detected seminal plasma, sperm liquefaction occurred concurrently with activation, which was enhanced...
The objective of the present work was to study effect a nonsteroidal aromatase inhibitor (fadrozole) on proliferation, estradiol production, expression and telomerase activity (TA) in pig granulosa cells (GC) from small (1-2 mm) large (5-7 follicles. were treated with fadrozole for 48 h 72 basal FSH-stimulated conditions. Fadrozole caused decrease (P < 0.05) 3H-thymidine incorporation derived follicles mm). proliferative potential small-follicle GC significantly higher 0.01) under all...
Stem Cell Characteristics of Ovarian Granulosa Cells - Review Recently increasing interest in stem cells mammalian ovary has been observed. Potential somatic for the follicular theca and ovarian surface epithelium have demonstated. On other hand, despite intensive research, difinitive evidence cell characteristics granulosa is still to be found. Elucidation properties may important implications both from scientific clinical point view. The aim this work review current knowledge about...
1. Stem Cell Characteristics of Ovarian Granulosa Cells - Review Ewa Chronowska Annals Animal Science CrossRef
The aim of the present work was to determine relative transcript abundance oestrogen receptor alpha (ERα) and beta (ERβ) gene in long-term cultures (up 18 days) pig granulosa cells (GC) obtained from small (1-2 mm; SF-GC) large (5-7 LF-GC) follicles.GC were cultured presence 10% foetal calf serum (FCS) one following growth factors: leukaemia inhibitory factor (LIF), basic fibroblast (bFGF), or stem cell (SCF).The investigated genes measured by real time PCR (RT-PCR).In comparison with...