A5045738939- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Genetics and Neurodevelopmental Disorders
- Memory Processes and Influences
- Epilepsy research and treatment
- Adipose Tissue and Metabolism
- Vagus Nerve Stimulation Research
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Phytoestrogen effects and research
- Cognitive Abilities and Testing
- Axon Guidance and Neuronal Signaling
- Neuroscience, Education and Cognitive Function
- Mast cells and histamine
- Vestibular and auditory disorders
- Adenosine and Purinergic Signaling
- Congenital heart defects research
Otto-von-Guericke University Magdeburg
2015-2024
Center for Behavioral Brain Sciences
2019-2023
Charité - Universitätsmedizin Berlin
2011-2017
Freie Universität Berlin
2014
Czech Academy of Sciences, Institute of Physiology
2010
Major depressive disorder (MDD) affects millions of individuals worldwide, leading to considerable social and economic costs. Despite advancements in pharmacological treatments, achieving remission remains a key challenge, with substantial number patients showing resistance existing therapies. This is often associated elevated levels proinflammatory cytokines, suggesting connection between inflammation, MDD pathophysiology, treatment efficacy. The observation increased immune activation...
The mechanisms that regulate the strength of synaptic transmission and intrinsic neuronal excitability are well characterized; however, promote disease-causing neural network dysfunction poorly defined. We generated mice with targeted neuron type–specific expression a gain-of-function variant neurotransmitter receptor for glycine (GlyR) is found in hippocampectomies from patients temporal lobe epilepsy. In this mouse model, GlyR terminals glutamatergic cells or parvalbumin-positive...
Parvalbumin-positive (PV) basket cells provide perisomatic inhibition in the cortex and hippocampus control generation of memory-related network activity patterns, such as sharp wave ripples (SPW-R). Deterioration this class fast-spiking interneurons has been observed neuropsychiatric disorders evidence from animal models suggests their involvement acquisition extinction fear memories. Here, we used mice with neuron type-targeted expression presynaptic gain-of-function glycine receptor RNA...
Abstract Cholinergic neuromodulation in the hippocampus controls salience of background context memory acquired presence elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells dentate gyrus mediate devaluation during Pavlovian fear conditioning. The adjustment is sensitive to reduction neuropeptide Y (NPY) expression via dominant negative CREB HIPP and acute blockage NPY-Y1 receptors We...
Sharp wave–ripple complexes (SPW-Rs) in the intact rodent hippocampus are characterized by slow field potential transients superimposed close to 200-Hz ripple oscillations. Similar events have been recorded hippocampal slices where SPW-Rs occur spontaneously or can be induced repeated application of high-frequency stimulation, a standard protocol for induction long-lasting long-term potentiation. Such stimulation is reminiscent protocols used induce kindling epilepsy and oscillations may...
Childhood trauma is a well‐described risk factor for the development of stress‐related psychopathology such as posttraumatic stress disorder or depression later in life. adversity can be modeled rodents by juvenile (JS) protocols, resulting impaired coping with stressful challenges adulthood. In current study, we investigated long‐lasting impact JS on expression molecular factors glutamate and γ‐aminobutyric acid (GABA) uptake turnover sublayers dentate gyrus (DG) using laser microdissection...
Summary Objective The need for alternative pharmacologic strategies in treatment of epilepsies is pressing about 30% patients with epilepsy who do not experience satisfactory seizure control present treatments. In temporal lobe ( TLE ) even up to 80% are pharmacoresistant, and surgical resection the ictogenic tissue only possible a minority patients. this study we investigate purinergic modulation drug‐resistant seizure‐like events SLE s) human cortex slices. Methods Layer V/ VI field...
Abstract Stressful experiences do not only cause peripheral changes in stress hormone levels, but also affect central structures such as the hippocampus, implicated spatial orientation, evaluation, and learning memory. It has been suggested that formation of memory traces is dependent on hippocampal gamma oscillations observed during alert behaviour rapid eye movement sleep. Furthermore, quiescent behaviour, sharp wave‐ripple ( SW ‐ R ) activity emerges. These events provide a temporal...
Epilepsies are multifaceted neurological disorders characterized by abnormal brain activity, e.g. caused imbalanced synaptic excitation and inhibition. The neural extracellular matrix (ECM) is dynamically modulated physiological pathophysiological activity critically involved in controlling the brain's excitability. We used different epilepsy models, i.e. mice lacking presynaptic scaffolding protein Bassoon at excitatory, inhibitory or all synapse types as genetic models for rapidly...
Bassoon is a large scaffolding protein of the presynaptic active zone involved in development terminals and regulation neurotransmitter release at both excitatory inhibitory brain synapses. Mice with constitutive ablation (Bsn) gene display impaired function, show sensory deficits develop severe seizures. To specifically study role forebrain synapses its relevance for control behavior, we generated conditional knockout (Bsn cKO) mice by through an Emx1 promoter-driven Cre recombinase. In...
Abstract Agents such as sertindole and astemizole affect heart action by inducing long‐ QT syndrome, suggesting that apart from their neuronal actions through histamine receptors, 5‐ HT 2 serotonin receptors D2 dopamine they also ether‐a‐go‐go channels particularly ‐related ( ERG ) potassium (K + channels, comprising the K v 11.1, 11.2 11.3 voltage‐gated currents. Changes in channel expression activity have been reported may be linked to schizophrenia [Huffaker, S.J., Chen, J., Nicodemus,...
Abstract Objective Memory impairment is common in patients with temporal lobe epilepsy and seriously affects life quality. Chronic stress a recognized cofactor can also impair memory function. Furthermore, increased cortisol levels have been reported patients. Animal models suggested that aggravating effects of on synaptic plasticity were mediated via glucocorticoids. The aim this study was, therefore, to investigate the effect glucocorticoid receptor (GR) modulation human cortex Methods We...
Abstract A traumatic childhood is among the most important risk factors for developing stress‐related psychopathologies such as posttraumatic stress disorder or depression later in life. However, despite proven role of astrocytes regulating transmitter release and synaptic plasticity, contribution astrocytic metabolism to stress‐induced currently not understood. In rodents, adversity can be modeled by juvenile exposure, resulting increased anxiety, impaired coping with adulthood. We describe...
A presynaptic active zone organizer protein Bassoon orchestrates numerous important functions at the zone. We previously showed that absence of exclusively in forebrain glutamatergic presynapses (BsnEmx1cKO) mice leads to developmental disturbances dentate gyrus (DG) affecting synaptic excitability, morphology, neurogenesis and related behaviour during adulthood. Here, we demonstrate hyperexcitability medial perforant path-to-DG (MPP-DG) pathway BsnEmx1cKO emerges adolescence is sustained...
Remembering the location of food is essential for survival. Rodents and humans employ mainly hippocampus-dependent spatial strategies, but when being stressed they shift to striatum-mediated stimulus-based strategies. To investigate underlying brain circuits, we tested mice with a heightened stress susceptibility due lack GABA-synthetizing enzyme GAD65 (GAD65-/- mice) in dual solution task. Here, GAD65-/- preferred locate reward an open field via proximal cue, while their wildtype...
Introduction: Phytoestrogens are non-steroidal estrogen analogues and found primarily in soy products. They have received increasing attention as dietary supplements for deficiency modulators of endogenous functions, including cognition emotion. In addition to modifying the levels circulating sex hormones, phytoestrogens also exert direct effects on androgen receptors brain thus effectively modulate neural circuit functions.Objective: The aim this study was investigate long-term low...