A5087588950- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Ion channel regulation and function
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- RNA regulation and disease
- Neural dynamics and brain function
- Barrier Structure and Function Studies
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Pharmacological Effects and Toxicity Studies
- Autoimmune Neurological Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- Neurogenesis and neuroplasticity mechanisms
- RNA modifications and cancer
- Infant Health and Development
- Neurological disorders and treatments
- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Genomics and Rare Diseases
- Human-Animal Interaction Studies
- Ion Transport and Channel Regulation
- Pediatric Pain Management Techniques
- Retinal Development and Disorders
- Adenosine and Purinergic Signaling
Tufts University
2022-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2022
Universitätsklinikum Erlangen
2022
Albert Einstein College of Medicine
2018
Charité - Universitätsmedizin Berlin
2012-2017
Yeshiva University
2017
Boğaziçi University
2011-2016
Istanbul University
2005
We tested the hypothesis that interstitial albumin can contribute to pharmacoresistance, which is common among patients with focal epilepsies. These often present an open blood-brain barrier (BBB), resulting in diffusion of drug-binding into brain space.Seizure-like events (SLEs) induced by 100 μm 4-aminopyridine (4-AP) were monitored using extracellular field potential recordings from acute rat entorhinal cortex-hippocampus slices. Effects standard antiepileptic drugs (phenytoin, valproic...
Peri-infarct opening of the blood-brain barrier may be associated with spreading depolarizations, seizures, and epileptogenesis as well cognitive dysfunction. We aimed to investigate mechanisms underlying neural network pathophysiology in barrier-dysfunctional hippocampus. Photothrombotic stroke within rat neocortex was increased intracranial pressure, vasogenic edema, peri-ischemic dysfunction that included ipsilateral Intrahippocampal recordings revealed electrographic seizures first week...
Neuroactive steroids (NAS), which are synthesized in the brain from progesterone, exert potent effects on behavior and used to treat postpartum depression, yet how these compounds induce sustained modifications neuronal activity ill-defined. Here, we examined efficacy of NAS for membrane progesterone receptors (mPRs) δ ε, members a family GPCRs progestins that expressed CNS. increase PKC via G q activation mPRδ with EC50s between 3-11nM. In contrast, they activate s mPRε potentiate PKA...
Summary Objective The need for alternative pharmacologic strategies in treatment of epilepsies is pressing about 30% patients with epilepsy who do not experience satisfactory seizure control present treatments. In temporal lobe ( TLE ) even up to 80% are pharmacoresistant, and surgical resection the ictogenic tissue only possible a minority patients. this study we investigate purinergic modulation drug‐resistant seizure‐like events SLE s) human cortex slices. Methods Layer V/ VI field...
Abstract Objective Memory impairment is common in patients with temporal lobe epilepsy and seriously affects life quality. Chronic stress a recognized cofactor can also impair memory function. Furthermore, increased cortisol levels have been reported patients. Animal models suggested that aggravating effects of on synaptic plasticity were mediated via glucocorticoids. The aim this study was, therefore, to investigate the effect glucocorticoid receptor (GR) modulation human cortex Methods We...
Statins provide strong clinical benefits via reducing stroke deaths, and they are also considered for tumor reduction chemo-sensitization. High dose atorvastatin in adults (80 mg daily, approx. 1 mg/kg) is proven to afford greater protection against cardiac deaths than does a standard lipid-lowering coronary syndrome. For cancer trials, mega doses up 30 mg/kg have been used short term treatments but neither high nor mega-dose of has tested long safety. This may be special concern, since some...
Abstract Sharp wave-ripples (SWRs) are hippocampal oscillations associated with memory consolidation. The subiculum, as the output structure, ensures that representations transferred correctly to consolidating neocortical regions. Because patients temporal lobe epilepsy often develop deficits, we hypothesized epileptic networks may disrupt subicular SWRs. We therefore investigated impact of experimentally induced status epilepticus (SE) on SWRs and contributing pyramidal neurons using...
C-terminal Binding Protein 1 (CTBP1) is a ubiquitously expressed transcriptional co-repressor and membrane trafficking regulator. A recurrent de novo c.991C>T mutation in CTBP1 leads to expression of p.R331W causes hypotonia, ataxia, developmental delay, tooth enamel defects syndrome (HADDTS), rare early onset neurodevelopmental disorder. We generated hESCs lines with heterozygote homozygote using CRISPR/Cas9 genome editing validated them for genetic integrity, off-target mutations,...