A5085479657- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Neural dynamics and brain function
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Drug Transport and Resistance Mechanisms
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Ion Transport and Channel Regulation
- Sleep and Wakefulness Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Botulinum Toxin and Related Neurological Disorders
- Cardiac electrophysiology and arrhythmias
- Neurosurgical Procedures and Complications
- Nicotinic Acetylcholine Receptors Study
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced NMR Techniques and Applications
- EEG and Brain-Computer Interfaces
- Intracranial Aneurysms: Treatment and Complications
- Adenosine and Purinergic Signaling
- Transcranial Magnetic Stimulation Studies
- Cholinesterase and Neurodegenerative Diseases
New York University
2022-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2023
NYU Langone Health
2023
Universitätsklinikum Erlangen
2021-2022
University Hospital Bonn
2016-2021
University of Bonn
2016
Charité - Universitätsmedizin Berlin
2011-2015
University of Münster
2011
Medizinische Hochschule Hannover
2011
Abstract Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results from intracerebral haemorrhage, and early delayed cerebral ischaemia. The prospective, observational, multicentre, cohort, diagnostic phase III trial, DISCHARGE-1, primarily investigated whether the peak total spreading depolarization-induced depression duration of a recording day during neuromonitoring (delayed duration) indicates ipsilateral infarction. Consecutive patients (n = 205) who required...
We tested the hypothesis that interstitial albumin can contribute to pharmacoresistance, which is common among patients with focal epilepsies. These often present an open blood-brain barrier (BBB), resulting in diffusion of drug-binding into brain space.Seizure-like events (SLEs) induced by 100 μm 4-aminopyridine (4-AP) were monitored using extracellular field potential recordings from acute rat entorhinal cortex-hippocampus slices. Effects standard antiepileptic drugs (phenytoin, valproic...
Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but also present other neurological diseases, such as Alzheimer's disease (AD). Understanding the role IEDs have on hippocampal circuit is important for our understanding of cognitive deficits seen and AD. We characterize compare human from microwire recording with those AD transgenic mice implanted multilayer silicon probes. Both local field potential features...
Abstract Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization rodents, their application as biomarkers to track and treat dysfunction humans is limited by coarse spatial sampling, interference from interictal epileptiform discharges (IEDs), lack of consensus on human SPW-R localization morphology. We demonstrate that mouse hippocampal share spatial, spectral temporal features, which clearly...
Experimental and clinical evidence suggests that prolonged spreading depolarizations (SDs) are a promising target for therapeutic intervention in stroke because they recruit tissue at risk into necrosis by protracted intracellular calcium surge massive glutamate release. Unfortunately, unlike SDs healthy tissue, resistant to drugs such as N-methyl-d-aspartate-receptor antagonists. This drug resistance of SD low perfusion areas may be due the gradual rise extracellular potassium before onset....
Summary Purpose: Adenosine is considered an endogenous anticonvulsant. However, much less known about the putative effects of its precursor, ATP, on epilepsy. Therefore, we tested whether ATP and receptors are able to modulate epileptiform activity in medial entorhinal cortex rat. Methods: Recurrent discharges (REDs) were induced by elevating extracellular potassium concentration combined with application bicuculline brain slices from naive pilocarpine‐treated chronic epileptic rats. Field...
Abstract Objective Memory impairment is common in patients with temporal lobe epilepsy and seriously affects life quality. Chronic stress a recognized cofactor can also impair memory function. Furthermore, increased cortisol levels have been reported patients. Animal models suggested that aggravating effects of on synaptic plasticity were mediated via glucocorticoids. The aim this study was, therefore, to investigate the effect glucocorticoid receptor (GR) modulation human cortex Methods We...
Glutamate is the most important excitatory neurotransmitter in brain. The ability to assess glutamate release and re-uptake with high spatial temporal resolution crucial understand involvement of this primary both normal brain function different neurological disorders. Real-time imaging transients by fluorescent nanosensors has been accomplished rat slices. We performed for first time single-wavelength nanosensor human cortical slices obtained from patients who underwent epilepsy surgery....
Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but also present other neurological disease, such as Alzheimer's Disease (AD). Understanding the role IEDs have on hippocampal circuit is important for our understanding of cognitive deficits seen and AD. We characterize compare human from microwire recording with those AD transgenic mice implanted multi-layer silicon probes. Both local field potential features...
Abstract Aim The aim of this study was to re‐evaluate risk factors for post‐ICH epilepsy (PICHE) and examine the impact surgical hematoma evacuation on development after ICH. Background purpose Epilepsy is a common complication intracerebral hemorrhage (ICH). Information still scarce role ICH remains uncertain. Methods We retrospectively included patients with spontaneous treated in our hospital 2006–2019. Patients' medical records were analyzed. In addition, mailed questionnaires telephone...
Abstract Sharp wave-ripples (SWRs) are hippocampal oscillations associated with memory consolidation. The subiculum, as the output structure, ensures that representations transferred correctly to consolidating neocortical regions. Because patients temporal lobe epilepsy often develop deficits, we hypothesized epileptic networks may disrupt subicular SWRs. We therefore investigated impact of experimentally induced status epilepticus (SE) on SWRs and contributing pyramidal neurons using...