A5082881744- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Pain Management and Treatment
- Atomic and Subatomic Physics Research
- Spatial Neglect and Hemispheric Dysfunction
- Migraine and Headache Studies
- Platelet Disorders and Treatments
- Neural and Behavioral Psychology Studies
- Botulinum Toxin and Related Neurological Disorders
- Fractal and DNA sequence analysis
- Advanced Memory and Neural Computing
- Stroke Rehabilitation and Recovery
- Neurobiology of Language and Bilingualism
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Music Perception
- Natural Compound Pharmacology Studies
Neuroscience Institute
2025
NYU Langone Health
2013-2025
Epilepsy Foundation
2019-2025
New York University
2015-2025
Center for Neuro-Oncology
2025
Indiana University School of Medicine
2024
Pulmonary and Critical Care Associates
2024
Daiichi Sankyo (United States)
2024
Qilu Hospital of Shandong University
2018-2022
Neurosciences Institute
2021-2022
Transcranial electric stimulation aims to stimulate the brain by applying weak electrical currents at scalp. However, magnitude and spatial distribution of fields in human are unknown. We measured potentials intracranially ten epilepsy patients estimated across entire leveraging calibrated current-flow models. When stimulating 2 mA, cortical reach 0.8 V/m, lower limit effectiveness animal studies. individual whole-head anatomy is considered, predicted field magnitudes correlate with recorded...
Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current (tACS) can entrain enhance rhythms related to memory, but the evidence from non-invasive recordings remained inconclusive. Here, we measure endogenous spindle theta intracranially during low-frequency tACS find no stable entrainment of power non-REM sleep, nor resting...
Sensory input arrives in continuous sequences that humans experience as segmented units, e.g., words and events. The brain's ability to discover regularities is called statistical learning. Structure can be represented at multiple levels, including transitional probabilities, ordinal position, identity of units. To investigate sequence encoding cortex hippocampus, we recorded from intracranial electrodes human subjects they were exposed auditory visual containing temporal regularities. We...
Memory consolidation is hypothesized to involve the distribution and restructuring of memory representations across hippocampal cortical regions. Theories suggest that, through extended hippocampal–cortical interactions, ensembles come represent more integrated, or overlapping, traces that prioritize commonalities related memories. Sleep processes, particularly fast sleep spindles, are thought support consolidation, but evidence for this relationship has been mostly limited retention...
Abstract Objective To describe seizure outcomes in patients with medically refractory epilepsy who had evidence of bilateral mesial temporal lobe (MTL) onsets and underwent MTL resection based on chronic ambulatory intracranial EEG (ICEEG) data from a direct brain‐responsive neurostimulator (RNS) system. Methods We retrospectively identified all at 17 centers were treated the RNS System using leads, whom an was subsequently performed. Presumed lateralization routine presurgical approaches...
Abstract Slow oscillations and spindle activity during non-rapid eye movement sleep have been implicated in memory consolidation. Closed-loop acoustic stimulation has previously shown to enhance slow improve verbal associative memory. We assessed the effect of closed-loop a daytime nap on virtual reality spatial navigation task 12 healthy human subjects randomized within-subject crossover design. show robust enhancement oscillation sleep. However, no effects behavioral performance were...
Abstract We describe the spatiotemporal course of cortical high-gamma activity, hippocampal ripple activity and interictal epileptiform discharges during an associative memory task in 15 epilepsy patients undergoing invasive EEG. Successful encoding trials manifested significantly greater hippocampus frontal regions. cued recall sustained compared to failed responses. Hippocampal rates were successful retrieval trials. Interictal associated with 15% decreased odds remembering (95% confidence...
To characterize dementia-induced changes in visual art production.Although case studies show altered artistic production some patients with neurodegenerative disease, no case-controlled have quantified this phenomenon across groups of patients.Forty-nine subjects [18 Alzheimer 9 frontotemporal dementia (FTD), semantic (SD), 15 healthy older controls (NC)] underwent formal neuropsychologic testing visuospatial, perceptual, and creative functioning, produced 4 drawings. Subjective elements...
Sleep spindles have been implicated in memory consolidation and synaptic plasticity during NREM sleep. Detection accuracy latency automatic spindle detection are critical for real-time applications.Here we propose a novel deep learning strategy (SpindleNet) to detect sleep based on single EEG channel. While the majority of methods used off-line applications, our method is well suited online applications.Compared with other methods, SpindleNet achieves superior speed, as demonstrated two...
Abstract Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization rodents, their application as biomarkers to track and treat dysfunction humans is limited by coarse spatial sampling, interference from interictal epileptiform discharges (IEDs), lack of consensus on human SPW-R localization morphology. We demonstrate that mouse hippocampal share spatial, spectral temporal features, which clearly...
In studies comparing clinical practice to evidence-based standards, researchers have found that quality of care is inconsistently provided different segments the population in both developing and developed countries. To test hypothesis varies widely within countries, we conducted a prospectively designed evaluation for three common conditions: diarrhoea, tuberculosis prenatal care. Five countries participated study: China, Philippines, Mexico, El Salvador India. Within each country,...
Abstract Immune thrombocytopenia (ITP) is an autoimmune disorder, in which megakaryocyte dysfunction caused by reaction can lead to thrombocytopenia, although the underlying mechanisms remain unclear. Here, we performed single-cell transcriptome profiling of bone marrow CD34 + hematopoietic stem and progenitor cells (HSPCs) determine defects megakaryopoiesis ITP. Gene expression, cell-cell interactions, transcriptional regulatory networks varied HSPCs ITP, particularly immune cell...
To use arterial spin labeling (ASL) to compare cerebral blood flow (CBF) patterns in minimally conscious state (MCS) patients with those normal controls an observational study design.Subjects meeting MCS criteria and were identified. A pseudocontinuous ASL sequence was performed subjects the resting awake state. Multiple CBF values for 10 predetermined regions of interest sampled average calculated compared between subjects.Ten identified, ages ranging from 26 54 years. Four met received...
Patients presenting with left-sided FTLD syndromes sometimes develop a new preoccupation art, greater attention to visual stimuli, and increased creativity. We describe the case of 53-year-old, right-handed man history bipolar disorder who presented language behavior impairments characteristic FTLD, then developed motor symptoms consistent second diagnosis amyotrophic lateral sclerosis. Though patient had never created art before, he compulsion for painting beginning at earliest stages his...