A5101692563- Epilepsy research and treatment
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Hemispheric Asymmetry in Neuroscience
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- Diet and metabolism studies
- Neurological and metabolic disorders
- Vitamin D Research Studies
- Advanced Battery Technologies Research
- Neuroendocrine regulation and behavior
- Psychosomatic Disorders and Their Treatments
- Neurobiology of Language and Bilingualism
- Infectious Encephalopathies and Encephalitis
- Sleep and Wakefulness Research
- Cardiac electrophysiology and arrhythmias
- Climate Change and Health Impacts
- Radiation Effects in Electronics
- Cerebrospinal fluid and hydrocephalus
- Forensic Toxicology and Drug Analysis
- Vehicle emissions and performance
- Spinal Dysraphism and Malformations
Swedish Medical Center
2005-2022
Seattle University
2007-2022
Henry Ford Hospital
2020
Mayo Clinic
2020
Johns Hopkins University
2013-2020
Cleveland Clinic
2020
Neurosciences Institute
2007
Walsh University
2005
Beth Israel Deaconess Medical Center
2005
Howard Hughes Medical Institute
2005
<h3>Objective</h3> To prospectively evaluate safety and efficacy of brain-responsive neurostimulation in adults with medically intractable focal onset seizures (FOS) over 9 years. <h3>Methods</h3> Adults treated 2-year feasibility or randomized controlled trials were enrolled a long-term prospective open label trial (LTT) to assess safety, efficacy, quality life (QOL) an additional 7 Safety was assessed as adverse events (AEs), median percent change seizure frequency responder rate, QOL the...
Abstract Objective To describe seizure outcomes in patients with medically refractory epilepsy who had evidence of bilateral mesial temporal lobe (MTL) onsets and underwent MTL resection based on chronic ambulatory intracranial EEG (ICEEG) data from a direct brain‐responsive neurostimulator (RNS) system. Methods We retrospectively identified all at 17 centers were treated the RNS System using leads, whom an was subsequently performed. Presumed lateralization routine presurgical approaches...
To evaluate the prevalence and natural history of sleepiness following traumatic brain injury.This prospective cohort study used Sickness Impact Profile to in 514 consecutive subjects with injury (TBI), 132 non-cranial trauma controls, 102 trauma-free controls 1 month year after injury.Fifty-five percent TBI subjects, 41% 3% endorsed or more items (p < .001). One injury, 27% 23% 1% Patients were sleepier than at .02) but not injury. Brain-injured divided into injury-severity groups based on...
Diffusion-weighted imaging (DWI) can help to diagnose acute ischemic stroke. Other nonischemic disorders may show abnormal signals with DWI. The authors report two cases of Wernicke encephalopathy DWI signal changes in characteristic midline locations, one reduction apparent diffusion constant and without. abnormalities suggest early thiamine deficiency are useful diagnosing encephalopathy.
Clinical trials of a brain-responsive neurostimulator, RNS® System (RNS), excluded patients with vagus nerve stimulator, VNS® (VNS). The goal this study was to evaluate seizure outcomes and safety concurrent RNS VNS stimulation in adults drug-resistant focal-onset seizures.
On his second voyage of discovery, Captain James Cook charted much the South Pacific. The journey was long, from 1772 to 1775. During exploration, geographic, ethnographic, and scientific variety provided no shortage work for accompanying naturalists, astronomers, navigators, painters. Culinary discoveries included new species fish, many which were sketched, dressed, ultimately eaten. examined journals correspondence document clinical poisonings after ingestion two different fish. findings...
Summary: Objective: To demonstrate that seizure frequency in patients undergoing video EEG telemetry does not correlate with atmospheric pressure (AP) changes. Method: Historical automated AP data from weather stations the Seattle Metropolitan area were correlated to and type consecutive at our institution April 2005–April 2006. Daily maximum, minimum range of pressures daily number events (seizures, pseudoseizures, unknown) per patient. Alternatively, whether or occurred during a change...
This study aimed to investigate mirtazapine-induced changes in responsive neurostimulator (RNS) recordings a patient with epilepsy.Cortical detection/stimulation counts from an RNS implanted bitemporal epilepsy were matched mirtazapine use see if that drug altered hippocampal excitability.Mirtazapine decreased stability; when was held after washout period, DSC declined, but it retrialed, increased. Responsive system data helped design optimal and individualized medication regimen for our...
Abstract Background Skateboarders, snowboarders, and surfers all show stance preferences for which foot is forward while moving. We are unaware of other animals than humans with a preference, perhaps excepting Osprey, who fly their caught fish beneath them in foot‐forward stance. hypothesize there should be no difference between left forward, right back (conventional) versus (goofy) stances or holding unilateral foot. Online, publicly available, convenience images Osprey catching were...
Sex hormones can influence the timing and frequency of seizure activity. In addition, gender may age epilepsy onset hemispheric location focal epilepsy. Whether alters temporal lobe pathologies differentially is not clear. this study, we assess if neocortical or hippocampal from patients who underwent en bloc anteriomedial lobectomy (AMTR) for medically refractory differ by gender.Consecutive AMTR resections (n = 128), including tissues, were systematically studied. Cortical intracortical...
We sought to understand better the experience of seizures by studying differences in subjective being an earthquake between patients with epileptic (EP) and nonepileptic (NES) seizures.Forty-eight CCTV/EEG-documented EP or NES who were Seattle metropolitan area during February 28, 2001 Nisqually randomly selected for telephone interviews on their experiences, including whether they thought having a seizure event.Twenty-three percent spontaneously volunteered that initially as compared none...
Summary: Purpose: Several EEG‐based studies suggest that epileptiform activity originates from the left more than right hemisphere. In contrast, other pathophysiologies such as stroke lateralize relatively symmetrically. Study of focal slowing and EEG abnormalities allows assessment favoring well referral interpretation bias. Methods: The 1,331 consecutive adult reports were reviewed for discharges (EDs) nonepileptiform slowing. Side or EDs, interpreting electoencephalographer, whether...
To investigate if glucose levels influence seizure patterns.In a patient with RNS/NeuroPace implanted bi-temporally and type 1 diabetes mellitus, event times onset locations were matched to continuous tissue glucose.Left focal (LFS, n = 22) glucoses averaged 169 mg/dL, while right (RFS, 23) 131 mg/dL (p 0.03). LFS occurred at mean time 17:02 RFS 04:23. spread the contralateral side (n 19) more than 2).Seizure laterality vary of seizure.
Mortality associated with cannabis used for treatment of epilepsy is not well documented. We discuss two fatalities in the setting and self-determined therapy (SDTC). One patient had probable sudden unexpected death epilepsy, second was due to seizure-associated drowning. Both directed SDTC over conventional anti-seizure medications. Where recreational legal, decisions use are often self-directed independent physician advice risks, part because physicians may be aware risk SDTC. Further...
In 1810, two British ships, HMS <i>Triumph</i> and <i>Phipps</i>, salvaged a large load of elemental mercury from wrecked Spanish vessel near Cadiz, Spain. The bladders containing the soon ruptured. element spread about ships in liquid vapor forms. sailors presented with neurologic compromises: tremor, paralysis, excessive salivation as well tooth loss, skin problems, pulmonary complaints. events are reviewed context what was known inhalation.