A5086381479- Epilepsy research and treatment
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Vagus Nerve Stimulation Research
- Diet and metabolism studies
- Nausea and vomiting management
- Palliative Care and End-of-Life Issues
- Attention Deficit Hyperactivity Disorder
- Glycogen Storage Diseases and Myoclonus
- Neurology and Historical Studies
- Neuroscience and Neuropharmacology Research
- Tuberous Sclerosis Complex Research
- Pathogenesis and Treatment of Hiccups
- Psychosomatic Disorders and Their Treatments
- Neurofibromatosis and Schwannoma Cases
- Polyomavirus and related diseases
- Peripheral Nerve Disorders
- Anesthesia and Sedative Agents
- Metabolism and Genetic Disorders
- Mental Health and Psychiatry
- Vascular Procedures and Complications
University of Colorado Denver
2016-2023
Saint Anthony College of Nursing
2023
University of Colorado Anschutz Medical Campus
2020-2021
Matthew's Friends
2020
Johns Hopkins University
2020
Rush University Medical Center
2020
University of Toronto
2020
Hospital of the University of Pennsylvania
2016
University of Colorado Hospital
2016
Penn Center for AIDS Research
2013
Abstract Objective The RNS System is a direct brain‐responsive neurostimulation system that US Food and Drug Administration–approved for adults with medically intractable focal onset seizures based on safety effectiveness data from controlled clinical trials. purpose of this study was to retrospectively evaluate the real‐world System. Methods Eight comprehensive epilepsy centers conducted chart review patients treated at least 1 year, in accordance indication use. Data included...
Abstract Objective To describe seizure outcomes in patients with medically refractory epilepsy who had evidence of bilateral mesial temporal lobe (MTL) onsets and underwent MTL resection based on chronic ambulatory intracranial EEG (ICEEG) data from a direct brain‐responsive neurostimulator (RNS) system. Methods We retrospectively identified all at 17 centers were treated the RNS System using leads, whom an was subsequently performed. Presumed lateralization routine presurgical approaches...
<h3>Objective</h3> To evaluate current clinical practices and evidence-based literature to establish preliminary recommendations for the management of adults using ketogenic diet therapies (KDTs). <h3>Methods</h3> A 12-topic survey was distributed international experts on KDTs in consisting neurologists dietitians at medical institutions providing with epilepsy other neurologic disorders. Panel responses were tabulated by authors determine common disparate between compare these KDT children...
Objective. Recently the FDA approved first responsive, closed-loop intracranial device to treat epilepsy. Because these devices must respond within seconds of seizure onset and not miss events, they are tuned have high sensitivity, leading frequent false positive stimulations decreased battery life. In this work, we propose a more robust detection model. Approach. We use Bayesian nonparametric Markov switching process parse EEG (iEEG) data into distinct dynamic event states. Each state is...
Fluorodeoxyglucose-positron emission tomography (FDG-PET) is an established, independent, strong predictor of surgical outcome in refractory epilepsy. In this study, we explored the added value quantitative [18F]FDG-PET features combined with clinical variables, including electroencephalography (EEG), [18F]FDG-PET, and magnetic resonance imaging (MRI) qualitative interpretations, to predict long-term seizure recurrence (mean post-op follow-up 5.85 ± 3.77 years).Machine learning predictive...
Clinical trials of a brain-responsive neurostimulator, RNS® System (RNS), excluded patients with vagus nerve stimulator, VNS® (VNS). The goal this study was to evaluate seizure outcomes and safety concurrent RNS VNS stimulation in adults drug-resistant focal-onset seizures.
Tuberous sclerosis complex (TSC) is a genetic disorder primarily characterized by the development of multisystem benign tumors. Epilepsy most common neurologic manifestation, affecting 80%-90% TSC patients. The diffuse structural brain abnormalities and multifocal nature epilepsy in pose diagnostic challenges when evaluating patients for surgery.We retrospectively reviewed safety experience efficacy outcomes five adult who were treated with direct brain-responsive neurostimulation (RNS...
Epilepsy surgery (ES) can improve seizure outcome. A prolonged duration of presurgical evaluation contributes to epilepsy-related morbidity and mortality. We introduced process changes decrease time (ET) increase ES numbers (excluding vagus nerve stimulation).The University Colorado Hospital patient database was searched for ESs between January 2009 May 2016. Measures reduce ET included (1) increasing care conference (PCC) frequency; (2) faster intracarotid amobarbital test (IAT) scheduling;...
Epilepsy represents a complex spectrum disorder, with patients sharing seizures as common symptom and manifesting broad array of additional clinical phenotypes. To understand this disorder treat individuals who live epilepsy, it is important not only to identify pathogenic mechanisms underlying epilepsy but also their relationships other health-related factors. Benchmarks Area IV focuses on the impact treatment quality life, development, cognitive function, aspects comorbidities that often...
Here we present a unique, but important seizure variant directly related to placement of subdural grids. Two distinct epileptogenic zones were identified, one which correlated with the patient's baseline seizures and separate zone associated atypical semiology localization. Inspection this at surgery revealed cortical deformation from grid itself. The patient underwent successful surgical resection primary zone, not that zone. She remains free two years following surgery. Recognition...
<h3>Objective:</h3> We assessed the clinical impact of Microburst-VNS in an early feasibility study. <h3>Background:</h3> Vagus nerve stimulation (VNS) therapy is established treatment for drug-resistant epilepsy. New settings called "microburst stimulation" (μVNS) with high-frequency bursts are hypothesized to be more tolerable and efficacious than standard VNS therapy. <h3>Design/Methods:</h3> This prospective, unblinded multicenter study aimed recruit 2 cohorts 20 VNS-naïve patients each,...