A5064182892- Diet and metabolism studies
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Diet, Metabolism, and Disease
- Clinical Nutrition and Gastroenterology
- Gastroesophageal reflux and treatments
- Pregnancy and Medication Impact
- Muscle metabolism and nutrition
- Glycogen Storage Diseases and Myoclonus
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Bipolar Disorder and Treatment
- Effects and risks of endocrine disrupting chemicals
- Regulation of Appetite and Obesity
- Digestive system and related health
- Vitamin D Research Studies
Kempenhaeghe
2011-2020
Maastricht University Medical Centre
2015-2020
Matthew's Friends
2020
Johns Hopkins University
2020
Rush University Medical Center
2020
University of Toronto
2020
Maastricht University
2014-2017
In-Q-Tel
2012-2016
Japan External Trade Organization
2016
Summary Ketogenic dietary therapies ( KDTs ) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline management children on KDT was published, focusing topics patient selection, pre‐ counseling and evaluation, diet choice attributes, implementation, supplementation, follow‐up, side events, discontinuation. It has been...
Objective To evaluate the efficacy and tolerability of ketogenic diet (KD) during first 4 months a randomized controlled trial (RCT) in refractory epilepsy patients aged 1–18 years. Methods Children adolescents with epilepsy, not eligible for surgery, were included. Following 1 month at baseline, to either KD or care as usual (CAU).Primary outcome is proportion least 50% reduction seizure frequency months. Secondary outcomes are mean percentage baseline seizures, severity, side effects....
<h3>Objective</h3> To evaluate current clinical practices and evidence-based literature to establish preliminary recommendations for the management of adults using ketogenic diet therapies (KDTs). <h3>Methods</h3> A 12-topic survey was distributed international experts on KDTs in consisting neurologists dietitians at medical institutions providing with epilepsy other neurologic disorders. Panel responses were tabulated by authors determine common disparate between compare these KDT children...
Summary: Purpose: This study aimed at investigating the cognitive and mood effects of lamotrigine (LTG) versus valproate (VPA) placebo (PBO). Methods: By studying in healthy volunteers, it is possible to separate genuine LTG from improvements, caused by better seizure control. The used a pretest–posttest comparison 50 mg LTG, 900 VPA, or PBO double‐blind single‐dummy parallel‐group design with 30 volunteers. Study duration was 12 days (with last control on day 13). Outcome measures included...
The ketogenic diet (KD) is increasingly used for the treatment of refractory epilepsy. aim this study was to evaluate possible adverse effects on cognition, behavior, psychosocial adjustment, and quality life in school-aged children adolescents.Fifteen subjects were assessed before initiation. After approximately 6 months, 11 patients (73%) reassessed. We a combination individually administered psychological tests parent report questionnaires.Five 15 had seizure reduction more than 50%....
Epilepsy is a neurological disorder, characterized by recurrent unprovoked seizures which have high impact on the individual as well society whole. In addition to economic burden, epilepsy imposes substantial burden patients and their surroundings. Patients with uncontrolled depend heavily informal care health professionals. About 30% of suffer from drug-resistant epilepsy. The ketogenic diet can be treatment last resort, especially for children. beneficial effect has been proven, but...
Summary Objectives To gain insight into the cost‐effectiveness of ketogenic (KD) diet compared with care as usual (CAU) in children and adolescents intractable epilepsy, we conducted an economic evaluation from a societal perspective, alongside randomized controlled trial. Methods Participants tertiary epilepsy center were KD (intervention) group or CAU (control) group. Seizure frequency, quality adjusted life years (QALYs), health costs, production losses parents patient, family costs...
Summary: Introduction: Neurocognitive complaints may interfere with long‐term antiepileptic drug (AED) treatment and are an important issue in clinical practice. Most data about drug‐induced cognitive problems derived from highly controlled short‐term trials. We analyzed such for the two most commonly used AEDs a setting using patient perceived as primary outcome measure. Method: All patients of epilepsy center Kempenhaeghe that received topiramate (TPM) or levetiracetam (LEV) introduction...
To evaluate prospectively the influence of cyclic oral contraceptive (OC) use on lamotrigine (LTG) serum levels when used in combination therapy.Women with epilepsy using LTG valproate (VPA; n=7), carbamazepine (CBZ; n=3) or oxcarbazepine (OXC; n=1) were evaluated during two periods 28 days OC use, monitoring antiepileptic drug (AED) every other day dried blood spot sampling method. Results compared women monotherapy and OCs (n=12). Pharmacokinetic analysis was performed NONMEM software.Mean...