A5030432524- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Schizophrenia research and treatment
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Sleep and related disorders
- Diet and metabolism studies
- ECG Monitoring and Analysis
- Bipolar Disorder and Treatment
- Blind Source Separation Techniques
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Cardiac electrophysiology and arrhythmias
- Diabetes Treatment and Management
- Non-Invasive Vital Sign Monitoring
- Nonlinear Dynamics and Pattern Formation
- Metabolism and Genetic Disorders
- Parkinson's Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Restless Legs Syndrome Research
Eindhoven University of Technology
2014-2024
Kempenhaeghe
2015-2024
GGZ Drenthe
2006-2021
CURE International UK
2020
Signal Processing (United States)
2017-2019
Maastricht University Medical Centre
2018-2019
Stichting Epilepsie Instellingen Nederland
2018
Leiden University Medical Center
2018
Indiana University – Purdue University Indianapolis
2016
Indiana University School of Medicine
2016
Summary: Purpose: This study addressed whether cognitive impairment in children with epilepsy is caused by disease‐related stable factors, such as the type of epilepsy, or acute effects paroxysmal epileptic activity EEG discharges. We studied a nonselected group short nonconvulsive seizures, these seizures may elude detection and therefore persist over longer period. In this group, diagnostic issue to differentiate between combined several epilepsy‐related factors on cognition. Methods: All...
We treated 24 patients with narcolepsy for 4 weeks gammahydroxybutyrate (GHB), 60 mg/kg/night, in a randomized double-blind placebo-controlled cross-over trial. Both clinical and polysomnographic criteria were used to assess the results. Compared placebo, GHB reduced daily number of hypnagogic hallucinations (from 0.87 0.28; p = 0.008), daytime sleep attacks 2.27 1.40; 0.001) severity subjective sleepiness 1.57 1.24 on 0-4 scale; 0.028). The cataplexy was from 1.26 at baseline 0.56 after...
Impaired metacognition is associated with difficulties in the daily functioning of people psychosis. Metacognition can be divided into four domains: Self-Reflection, Understanding Other's Mind, Decentration, and Mastery. This study investigated whether Metacognitive Reflection Insight Therapy (MERIT) used to improve metacognition.This a randomized controlled trial. Patients active condition (n = 35) received forty MERIT sessions, control group treatment as usual. Multilevel...
<h3>Objective</h3> To develop and prospectively evaluate a method of epileptic seizure detection combining heart rate movement. <h3>Methods</h3> In this multicenter, in-home, prospective, video-controlled cohort study, nocturnal seizures were detected by (photoplethysmography) or movement (3-D accelerometry) in persons with epilepsy intellectual disability. Participants >1 monthly major wore bracelet (Nightwatch) on the upper arm at night for 2 to 3 months. Major tonic-clonic, generalized...
Educational difficulties or even severe cognitive deterioration is seen in many childhood epilepsy syndromes. Many of those deficits are related directly to the brain disorder underlying syndrome. However, other types epilepsy, epileptic seizures and/or epileptiform activity can be dominant factor. This especially unknown for more "subtle" short nonconvulsive seizure types. For this reason, we analyzed a new cohort children.A cross-sectional study 188 children with epilepsy....
Summary People with epilepsy need assistance and are at risk of sudden death when having convulsive seizures ( CS ). Automated real‐time seizure detection systems can help alert caregivers, but wearable sensors not always tolerated. We determined algorithm settings investigated performance a video to detect in residential care setting . The calculates power the 2‐6 Hz range relative 0.5‐12.5 group velocity signals derived from video‐sequence optical flow. A threshold was found using training...
Summary: Purpose: This study aimed at investigating the cognitive and mood effects of lamotrigine (LTG) versus valproate (VPA) placebo (PBO). Methods: By studying in healthy volunteers, it is possible to separate genuine LTG from improvements, caused by better seizure control. The used a pretest–posttest comparison 50 mg LTG, 900 VPA, or PBO double‐blind single‐dummy parallel‐group design with 30 volunteers. Study duration was 12 days (with last control on day 13). Outcome measures included...
The use of antipsychotics is associated with metabolic side effects, which put patients schizophrenia or related disorders at risk for cardiovascular morbidity. high interindividual variability in antipsychotic-induced abnormalities suggests that genetic makeup a possible determinant. In this cross-sectional study, we investigated whether genotypes the HTR2C receptor are syndrome using antipsychotics. Patients were identified from disease management program. program, patients' blood...
Summary Purpose: [18F]‐Fluoro‐ d ‐deoxyglucose positron emission tomography (FDG‐PET) is an expensive, invasive, and not widely available technique used in the presurgical evaluation of temporal lobe epilepsy. We assessed its added value to decision‐making process relation other commonly tests. Methods: In a retrospective study large series consecutive patients referred national Dutch epilepsy surgery program between 1996 2002, contribution FDG‐PET, magnetic resonance imaging (MRI),...
In a previous study, we found an association between 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) polymorphisms and the occurrence of metabolic syndrome in patients using antipsychotics. current set out to replicate our findings another sample explore pooled analysis both samples influence effect individual Data for this cross-sectional study came from 2 different samples, original (n = 112) replication 164). Primary end point was prevalence as classified by modified version National...
Summary Purpose: Learning and behavioral difficulties often occur in benign childhood epilepsy with centrotemporal spikes (BCECTS). In recent years, several electroencephalogram (EEG) characteristics have been related to the occurrence of learning problems. Methods: From 28 children medical, school psychological reports were present rated according a 4‐point scale for educational impairment (Part 1). Thirty 24‐h EEG recordings reanalyzed spike frequency, presence atypical criteria, nondipole...
Recent advances in miniaturization of ultra-low power components allow for more intelligent wearable health monitors. The development and evaluation a wireless electrocardiogram (ECG) monitor to detect epileptic seizures from changes the cardiac rhythm is described. ECG data are analyzed by embedded algorithms: robust beat-detection algorithm combined with real-time seizure detector. In its current implementation, proposed prototype 52× 36× 15mm 3 , has an autonomy one day. Based on...
In preparation for a multicenter randomized controlled trial, pilot study was conducted investigating the feasibility and acceptance of shortened version (12 vs. 40 sessions) an individual metacognitive psychotherapy (Metacognitive Reflection Insight Therapy [MERIT]). Twelve participants with diagnosis schizophrenia were offered 12 sessions MERIT. Effect sizes calculated changes from baseline to treatment end capacity measured by Metacognition Assessment Scale-Abbreviated. Nine twelve...
Automated seizure detection and alarming could improve quality of life potentially prevent sudden, unexpected death in patients with severe epilepsy. As currently available systems focus on tonic-clonic seizures, we want to detect a broader range types, including tonic, hypermotor, clusters seizures.In this multicenter, prospective cohort study, the nonelectroencephalographic (non-EEG) signals heart rate accelerometry were measured during night undergoing diagnostic video-EEG examination....