To determine the independent effects of depression and anxiety on health-related quality life (HRQOL) in epilepsy as well relative explanatory power psychiatric comorbidity compared with demographic clinical variables (e.g., seizure frequency, severity, chronicity).Subjects (n = 87) temporal lobe completed self-report measures depression, anxiety, HRQOL, severity. Information was derived regarding subjects' duration, treatment. HRQOL status (QOLIE-89) examined relation to self-reported...

<b><i>Objective:</i></b> To characterize the nature and degree of cognitive morbidity in patients with chronic temporal lobe epilepsy compared healthy control subjects, determine association between duration morbidity, ascertain whether there are factors that moderate disorder impairment. <b><i>Methods:</i></b> Temporal (n = 96) 82) subjects were assessed a comprehensive neuropsychological battery. Test performances adjusted for age, gender, education transformed to common metric (<i>z</i>...

Abstract Objective First, to determine whether patients with chronic temporal lobe epilepsy have a different cognitive trajectory compared control subjects over prospective 4‐year interval; second, the proportion of who exhibit abnormal change and their profile demographic, clinical epilepsy, baseline quantitative magnetic resonance imaging characteristics; third, most vulnerable domains. Methods Participants (n = 46) attending tertiary referral clinic healthy 65) underwent...

Recent studies suggest that Attention Deficit Hyperactivity Disorder (ADHD) is a common comorbid condition in childhood epilepsy, but little known regarding the nature, frequency and timing of associated neurobehavioural/cognitive complications or underlying aetiology ADHD epilepsy. This investigation examined: (i) prevalence its subtypes; (ii) association with abnormalities academic, neuropsychological, behavioural psychiatric status (iii) paediatric Seventy-five children (age 8–18)...

The aim of this study was to characterize the distribution, timing, and risk factors for psychiatric comorbidity in children with recent onset epilepsy. Children aged 8 18 years epilepsy (&lt;1 year duration) idiopathic etiology ( n =53) a healthy comparison group =50) underwent structured diagnostic interview spectrum lifetime‐to‐date history comorbid disorder. There no significant difference between sex (31 males, 22 females vs 23 27 females) or mean age 12.7y [SD 3.3] 3.2]). exhibited an...

This study characterizes the rate of current Axis I DSM–IV disorders using a brief standardized psychiatric interview procedure, Mini International Neuropsychiatric Interview (v5.0) (MINI), and determined validity MINI diagnoses depressive episodes to research standard (Structured Clinical for Disorders [SCID]). One hundred seventy-four patients with chronic epilepsy from five tertiary medical centers were interviewed mood module SCID. Current evident in one-half sample (49%), prevalent...

Summary: Purpose: Major depression is a common psychiatric comorbidity in chronic epilepsy that frequently unrecognized and untreated. A variety of self‐report mood inventories are available, but their validity as well ability to detect major remains uncertain. The purpose this study was determine the two depressive symptom identify people with epilepsy. Methods: In total, 174 adult patients underwent standardized interview techniques [Mini International Neuropsychiatric Interview (MINI)...

Summary Purpose: To characterize patterns and determinants of normal abnormal cognitive development in children with new onset epilepsy compared to healthy controls. Methods: Longitudinal (2‐year) growth was examined 100 children, age 8–18 years, including controls (n = 48) 52). Cognitive maturation as a function the presence/absence two neurobehavioral comorbitiies (attention deficit hyperactivity disorder and/or academic problems) identified at time diagnosis. Groups were across...

There is considerable interest in the assessment of executive function (EF) pediatric clinical populations but only a few well-standardized measures exist. We examined EF 53 children aged 8 to 18 years with recent onset epilepsy (31 males, 22 females) and 50 control (23 27 using Behavior Rating Inventory Executive Function (BRIEF) Delis-Kaplan System (D-KEFS). Thirty had localization-related 23 idiopathic generalized epilepsy; average duration 10 months (SD 4y 1mo) age 11 6 3y 6mo). The...

Summary Objective Benign epilepsy with centrotemporal spikes ( BECTS ), the most common focal childhood epilepsy, is associated subtle abnormalities in cognition and possible developmental alterations brain structure when compared to healthy participants, as indicated by previous cross‐sectional studies. To examine natural history of , we investigated cognition, cortical thickness, subcortical volumes children new/recent onset controls HC ). Methods Participants were 8–15 years age,...

Aim To characterize the prospective trajectory of cognitive development in children with new or recent onset epilepsy from baseline to 5 6 years after diagnosis. Method Sixty‐nine (40 males, 29 females; age 8–18y), epilepsies underwent neuropsychological assessment shortly diagnosis (Wave 1), 2 2), and 3). Intelligence, academic achievement, language, executive function, psychomotor speed were evaluated. Sixty‐two (28 34 8–18) typical served as a comparison group at each time point. The data...

Abstract Objective To identify cognitive phenotypes in temporal lobe epilepsy (TLE) and test their reproducibility a large, multi‐site cohort of patients using both data‐driven clinically driven approaches. Method Four‐hundred seven with TLE who underwent comprehensive neuropsychological evaluation at one four centers were included. Scores on tests verbal memory, naming, fluency, executive function, psychomotor speed converted into z ‐scores based 151 healthy controls (HCs). For the method,...

Abstract Objective This study evaluated the diagnostic performance of a widely available cognitive screener, Montreal assessment (MoCA), to detect impairment in older patients (age ≥ 55) with epilepsy residing US, using International Classification Cognitive Disorders Epilepsy (IC‐CoDE) as gold standard. Methods Fifty adults focal completed MoCA and neuropsychological measures memory, language, executive function, processing speed/attention. The IC‐CoDE taxonomy divided participants into...

Background An exaggerated recency effect (ie, disproportionate recall of last‐presented items) has been consistently observed in the word list learning patients with Alzheimer's disease (AD). Our study sought to determine whether there were similar alterations serial position among asymptomatic persons at risk for AD as a result parental family history. Methods Subjects included 623 middle‐aged children (median, 53 years) and 157 control participants whose parents survived least age 70...

Summary Purpose: To characterize prospective neurodevelopmental changes in brain structure children with new and recent‐onset epilepsy compared to healthy controls. Methods: Thirty‐four controls (mean age 12.9 years) 38 new/recent‐onset idiopathic underwent 1.5 T magnetic resonance imaging (MRI) at baseline 2 years later. Prospective total cerebral lobar gray white matter volumes were within between groups. Results: volume comparable for the control groups, significant (p &lt; 0.0001)...

Adults with juvenile myoclonic epilepsy (JME) have subtle brain structural abnormalities in the frontothalamocortical network, poorer cognitive function, and worse long-term social outcomes, even when their seizures are controlled and/or remitted. The natural history of JME development structure cognition from onset has not been studied.The maturational trajectories were prospectively compared between 19 children new-onset first 2 years after diagnosis 57 healthy controls.Cognitive abilities...