A5074814194- Multiple Sclerosis Research Studies
- Epilepsy research and treatment
- Childhood Cancer Survivors' Quality of Life
- Neuroscience and Neuropharmacology Research
- Autoimmune and Inflammatory Disorders Research
- Neurological disorders and treatments
- Peripheral Neuropathies and Disorders
- Pharmacological Effects and Toxicity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Cerebral Palsy and Movement Disorders
- Health, Environment, Cognitive Aging
- Neonatal and fetal brain pathology
- Vestibular and auditory disorders
- Family Support in Illness
- Alzheimer's disease research and treatments
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Traffic and Road Safety
- Bacterial Infections and Vaccines
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Genomic variations and chromosomal abnormalities
- Child Nutrition and Feeding Issues
- Adolescent and Pediatric Healthcare
University at Buffalo, State University of New York
2004-2019
Buffalo BioLabs
2014
Jacobs Institute
2007-2013
The Milton H. Erickson Foundation
2012
Women & Children's Hospital of Buffalo
2011
Rosalind Franklin University of Medicine and Science
2005-2008
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well those clinically isolated syndrome 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. had a mean 14.8 ± 2.6 years age an average disease duration 1.9 2.2 years. A total 65 (35%) 8 (18%) met criteria for impairment. The most frequent areas involved fine motor coordination...
Summary: Purpose: To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral contralateral hippocampus, temporal extratemporal lobe regions unilateral epilepsy (TLE). Methods: In total, 34 subjects with left (n = 15) or right 19) TLE were compared 65 healthy controls. Regions interest included hippocampus as well temporal, frontal, parietal, occipital gray white matter. Clinical markers neurodevelopmental insult (initial precipitating...
There is considerable interest in the assessment of executive function (EF) pediatric clinical populations but only a few well-standardized measures exist. We examined EF 53 children aged 8 to 18 years with recent onset epilepsy (31 males, 22 females) and 50 control (23 27 using Behavior Rating Inventory Executive Function (BRIEF) Delis-Kaplan System (D-KEFS). Thirty had localization-related 23 idiopathic generalized epilepsy; average duration 10 months (SD 4y 1mo) age 11 6 3y 6mo). The...
Background: Approximately one-third of those with pediatric-onset multiple sclerosis (MS) experience cognitive impairment. Less is known concerning their change in functioning over time. Objective: Changes function time were measured the largest pediatric cohort to date through US Network Pediatric MS Centers. Methods: A total 67 individuals ( n=62) or clinically isolated syndrome (CIS, n=5), ranging from 8–17 years age (mean age±standard deviation (SD)=14.37±2.02) completed initial and...
Fatigue and depression have been shown to be significant problems in children with multiple sclerosis. The rate at which these conditions occur other acquired demyelinating syndromes is unknown. In this cross-sectional study, the authors evaluated 49 disorders (multiple sclerosis acute disseminated encephalomyelitis) 92 healthy controls for and/or fatigue using Behavior Assessment System Children, Second Edition behavior mood rating scale Varni PedsQL Multidimensional Scale. parents of...
As many as 66% of systemic lupus erythematosus (SLE) patients have been reported to cognitive deficits. These deficits are often associated with information processing speed and working memory. Similarly, memory impairments the hallmark dysfunction in multiple sclerosis (MS). The Paced Auditory Serial Addition Test (PASAT) places high demands on Fisk Archibald, however, demonstrated that total score PASAT does not accurately reflect these processes. They found MS used a chunking strategy...
This study examined quantitative magnetic resonance volumes of the thalamus and hippocampus determined their relationship with cognitive function clinical seizure characteristics in a sample 46 unilateral temporal lobe epilepsy (TLE) subjects (20 left 26 right) 29 controls. The exhibited different patterns volume abnormality, associations characteristics, measures. Hippocampal reduction was primarily ipsilateral to focus, thalamic bilateral. Ipsilateral hippocampal significantly correlated...
Children with multiple sclerosis (MS) can suffer significant cognitive deficits. This study investigates the sensitivity and validity in pediatric MS of two visual processing tests borrowed from adult literature, Brief Visuospatial Memory Test-Revised (BVMTR) Symbol Digit Modalities Test (SDMT).To test hypothesis that is disproportionately impacted by comparing performance healthy controls on BVMTR SDMT.We studied 88 participants (43 MS, 45 controls) using a neuropsychological assessment...
The Brief Visuospatial Memory Test – Revised (BVMTR) and the Symbol Digit Modalities (SDMT) oral-only administration are known to be sensitive cerebral disease in adult samples, but pediatric norms not available. A demographically balanced sample of healthy control children (N = 92) ages 6–17 was tested with BVMTR SDMT. Multiple regression analysis (MRA) used develop controlled normative equations. This provided equations that were then construct adjusted z-scores for Trial 1, 2, 3, Total...
The National Multiple Sclerosis Society Consensus Neuropsychological Battery for Pediatric (NBPMS) was designed to detect cognitive impairment in children and adolescents with multiple sclerosis. One weakness of the battery is reliance on published manual-based normative samples varying size quality. These primary sources base interpretation discrete age bands, a practice which may be particularly problematic during periods rapid development childhood adolescence. A further impediment valid...
Pediatric-onset multiple sclerosis (POMS) is relatively rare, but as technology and neuroimaging advance, an increasing number of cases are identified, our understanding how (MS) impacts the developing brain improves. There consistent findings in literature highlighting impact MS other demyelinating diseases on cognitive functioning development. We also have a better POMS psychosocial functional outcomes daily living. This paper hopes to review associated with patients POMS, well explore...
Purpose: This is a prospective study of children with Lennox-Gastaut syndrome receiving clobazam as adjunctive therapy. pilot aims to examine medication effectiveness it relates seizure reduction, well improvement in parent-reported behavior and quality life (QOL). Methods: Ten patients aged 3-11 years were enrolled this 6-week, 4 phase study. Seizure frequency, QOL, Aberrant Behavior Checklist questionnaires evaluated at 0, 2, 6, 10 weeks during the Results: Patients showed on indices...
Pediatric-onset multiple sclerosis is relatively rare and research regarding disease characteristics in its infancy. Regardless, there are a growing number of studies finding early cognitive deficits this population. There some similarities outcomes to those seen the adult-onset population, but also several important differences. With specific regard functioning pediatric-onset sclerosis, evidence deficit nearly third patients, with impairment primarily areas processing speed, visual-spatial...
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the CNS. Its sequelae include both physical cognitive disability. Advances in neuropsychological testing screening have led to increased recognition impairment MS; more than half MS patients been found some degree impairment. Strong correlations between testing, brain atrophy other imaging techniques. These tools can aid comprehensive evaluation patients. Genetic markers, such as ApoE brain-derived neurotrophic...
OBJECTIVE: This study examined longitudinal changes in cognitive functioning among the pediatric multiple sclerosis (MS) population largest cohort to date representing U.S. Network of Pediatric MS Centers. BACKGROUND: is a rare variant adult-onset neurologic disease diagnosed under age 18 years, with an estimated frequency 0.5 1.0 per 100,000. Studies have found that approximately one-third children and adolescents some degree impairment. Less known concerning change over time, but initial...
OBJECTIVE: To characterize cognitive and behavioral functioning in children younger than 18 years of age with clinically isolated syndrome (CIS). BACKGROUND: Cognitive impairment is estimated to occur one third MS, but its frequency at the time first clinical event i.e. CIS, unknown. As occurs adults this disease stage, we hypothesized that impairments would also be identified pediatric CIS. DESIGN/METHODS: We evaluated 44 enrolled from six MS centers across USA. Participants completed a...