A5083396067- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Advanced Memory and Neural Computing
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Muscle activation and electromyography studies
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neuropharmacology Research
- Electromagnetic Fields and Biological Effects
- Molecular Communication and Nanonetworks
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience of respiration and sleep
- 3D Printing in Biomedical Research
- Circadian rhythm and melatonin
- Atomic and Subatomic Physics Research
- Neuroendocrine regulation and behavior
- Advanced NMR Techniques and Applications
- Electron Spin Resonance Studies
- Stress Responses and Cortisol
- Quantum-Dot Cellular Automata
New York University
2018-2025
Neurosciences Institute
2018-2025
NYU Langone Health
2019-2025
University of Michigan
2018-2024
Neuroscience Institute
2023
University of Szeged
2018-2020
Flatiron Health (United States)
2019
Flatiron Institute
2019
Transcranial electric stimulation is a non-invasive tool that can influence brain activity; however, the parameters necessary to affect local circuits in vivo remain be explored. Here, we report rodents and human cadaver brains, ~75% of scalp-applied currents are attenuated by soft tissue skull. Using intracellular extracellular recordings rats, find at least 1 mV/mm voltage gradient neuronal spiking subthreshold currents. We designed an 'intersectional short pulse' method inject...
Abstract The combination of in vivo extracellular recording and genetic-engineering-assisted optical stimulation is a powerful tool for the study neuronal circuits. Precise analysis complex neural circuits requires high-density integration multiple cellular-size light sources electrodes. However, inevitably introduces artifact. We present minimal-stimulation-artifact (miniSTAR) μLED optoelectrodes that enable effective elimination A multi-metal-layer structure with shielding layer...
Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intra- extra-cellular electrophysiological recordings. Genetically-identified classes neurons are optically manipulated, though the versatility optogenetics would be increased if independent control distinct neural populations could achieved on a sufficient spatial temporal resolution. We report scalable multi-site optoelectrode design that simultaneous optogenetic two spatially...
High-yield electrophysiological extracellular recording in freely moving rodents provides a unique window into the temporal dynamics of neural circuits. Recording from unrestrained animals is critical to investigate brain activity during natural behaviors. The use and implantation high-channel-count silicon probes represent largest cost experimental complexity associated with such recordings making recoverable reusable system desirable. To address this, we have designed tested novel 3D...
Abstract Dynamic interactions within and across brain areas underlie behavioral cognitive functions. To understand the basis of these processes, activities distributed local circuits inside a behaving animal must be synchronously recorded while inputs to are precisely manipulated. Even though recent technological advances have enabled such large‐scale recording capabilities, development high‐spatiotemporal‐resolution modulation techniques accompany those recordings has lagged. A novel neural...
BackgroundNotwithstanding advances with low-intensity transcranial electrical stimulation (tES), there remain questions about the efficacy of clinically realistic electric fields on neuronal function.ObjectiveTo measure magnitude and their effects firing rate hippocampal neurons in freely moving rats, to establish calibrated computational models current flow.MethodsCurrent flow were field measures motor cortex (n=2 anesthetized rats) hippocampus. A Neuropixels 2.0 probe 384 channels was used...
The ability to deliver flexible biosensors through the toughest membranes of central and peripheral nervous system is an important challenge in neuroscience neural engineering. Bioelectronic devices implanted dura mater thick epineurium would ideally create minimal compression acute damage as they reach neurons interest. We demonstrate that a three-dimensional diamond shuttle can be easily made with vertical support ultra-compliant polymer microelectrodes (4.5-µm thick) epineurium. has 54%...
During physiological conditions, brain temperature fluctuates approximately 3°C between sleep and active waking. Here, we show that features of hippocampal ripples, including the rate occurrence, peak frequency, duration are correlated with variations. Focal bidirectional manipulation in CA1 region awake rodents ripple frequency can be altered direction expected from correlational observations, implying plays a significant role.
Abstract Flexible implantable neurointerfaces show great promise in addressing one of the major challenges neurotechnology, namely loss signal connected to unfavorable probe tissue interaction. The authors here how multilayer polyimide probes allow high‐density intracortical recordings be combined with a reliable long‐term stable interface, thereby progressing toward chronic stability neurotechnology. could record 10–60 single units over 5 months consistent peak‐to‐peak voltage at dimensions...
Abstract Electric fields used in clinical trials with transcranial direct current stimulation (tDCS) are small, magnitudes that have yet to demonstrate measurable effects preclinical animal models. We hypothesized weak will nevertheless produce sizable effects, provided it is applied concurrently behavioral training, and repeated over multiple sessions. tested this here a rodent model of dexterous motor-skill learning. developed preparation allows concurrent during the performance...
Abstract Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization rodents, their application as biomarkers to track and treat dysfunction humans is limited by coarse spatial sampling, interference from interictal epileptiform discharges (IEDs), lack of consensus on human SPW-R localization morphology. We demonstrate that mouse hippocampal share spatial, spectral temporal features, which clearly...
Abstract Implantable active dense CMOS neural probes unlock the possibility of spatiotemporally resolving activity hundreds single neurons in multiple brain circuits to investigate dynamics. Mapping dynamics with anatomical structures spanning several millimeters, however, remains challenging. Here, a probe advancing lateral sampling for mapping intracortical (both LFPs and spikes) awake, behaving mice from an area >4 mm 2 is demonstrated. By taking advantage SiNAPS technology modularity,...
Brain states fluctuate between exploratory and consummatory phases of behavior. These state changes affect both internal computation the organism’s responses to sensory inputs. Understanding neuronal mechanisms supporting their switching requires experimental control behavioral shifts collecting sufficient amounts brain data. To achieve this goal, we developed ThermoMaze, which exploits animal’s natural warmth-seeking homeostatic By decreasing floor temperature selectively heating unmarked...
Electric fields used in clinical trials with transcranial direct current stimulation (tDCS) are small, magnitudes that have yet to demonstrate measurable effects preclinical animal models. We hypothesized weak will nevertheless produce sizable effects, provided it is applied concurrently behavioral training, and repeated over multiple sessions. tested this here a rodent model of dexterous motor-skill learning. developed preparation allows concurrent during the performance pellet-reaching...
We report a miniaturized, minimally invasive high-density neural recording interface that occupies only 1.53 mm2 footprint for hybrid integration of flexible probe and 256-channel integrated circuit chip. To achieve such compact form factor, we developed custom flip-chip bonding technique using anisotropic conductive film analog circuit-under-pad in tiny pitch 75 μm. enhance signal-to-noise ratios, applied reference-replica topology can provide the matched input impedance signal reference...
Abstract Over recent decades, optogenetics has become a pivotal technique for elucidating the functionality of neuronal circuits in living organisms. By genetically modifying specific cells within targeted tissues to respond particular optical stimuli, researchers can achieve precise activation or inhibition these cells. This capability enables detailed investigations neural circuitry with unprecedented accuracy. However, there is rising need hardware that supports bidirectional control...
<title>Abstract</title> Implantable active dense CMOS neural probes unlock the possibility of spatiotemporally resolving activity hundreds single neurons in multiple brain circuits to investigate dynamics. Mapping dynamics with anatomical structures spanning several millimeters, however, remains challenging. Here, we demonstrate first probe for mapping intracortical (both LFPs and spikes) awake, behaving mice from an area >4 mm2. By taking advantage modularity our SiNAPS technology,...
Extracellular recordings in freely moving animals allow the monitoring of brain activity from populations neurons at single-spike temporal resolution. While state-of-the-art electrophysiological recording devices have been developed recent years (e.g., µLED and Neuropixels silicon probes), implantation methods for probes rats mice not advanced substantially a decade. The surgery is complex, takes time to master, involves handling expensive valuable animal subjects. In addition, chronic...
Abstract As the use of Radio Frequency (RF) technologies increases, impact RF radiation on neurological function continues to receive attention. Whether can modulate ongoing neuronal activity by non-thermal mechanisms has been debated for decades. However, interactions between radiated energy and metal-based neural probes during experimentation could activity, making interpretation results difficult. To address this problem, we modified a miniature 1-photon Ca 2+ imaging device record...
Abstract Flexible intracortical neural probes have drawn attention for their enhanced longevity in high-resolution recordings due to reduced tissue reaction. However, the conventional monolithic fabrication approach has met significant challenges in: (i) scaling number of recording sites electrophysiology; (ii) integrating other physiological sensing and modulation; (iii) configuring into three-dimensional (3D) shapes multi-sided electrode arrays. We report an innovative self-assembly...