A5013744561- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Advanced Memory and Neural Computing
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural Networks and Applications
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Image and Signal Denoising Methods
- Neuroscience of respiration and sleep
- CCD and CMOS Imaging Sensors
- Nicotinic Acetylcholine Receptors Study
- Cognitive Science and Mapping
- Insect behavior and control techniques
- Insect Utilization and Effects
- Analytical Chemistry and Sensors
- Cell Image Analysis Techniques
Ludwig-Maximilians-Universität München
2015-2025
LMU Klinikum
2024
Bernstein Center for Computational Neuroscience Munich
2016-2023
Munich Cluster for Systems Neurology
2015-2021
Oregon Health & Science University
2021
Deutsche Forschungsgemeinschaft
2021
University of Tübingen
2011-2014
Rutgers, The State University of New Jersey
2003-2014
Bernstein Center for Computational Neuroscience Tübingen
2014
TH Bingen University of Applied Sciences
2010
Both neocortical and hippocampal networks organize the firing patterns of their neurons by prominent oscillations during sleep, but functional role these rhythms is not well understood. Here, we show a robust correlation neuronal discharges between somatosensory cortex hippocampus on both slow fine time scales in mouse rat. Neuronal bursts deep cortical layers, associated with sleep spindles delta waves/slow rhythm, effectively triggered related to fast (ripple) oscillations. We hypothesize...
Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding representation and storage information. Here we describe development micro-machined silicon microelectrode arrays unit local field recordings. The two-dimensional probes with 96 or 64 sites provided high-density minimal tissue displacement damage. on-chip active circuit eliminated movement other artifacts greatly reduced weight headgear. precise geometry tips allowed estimation spatial...
Low intensity electric fields have been suggested to affect the ongoing neuronal activity in vitro and human studies. However, physiological mechanism of how weak electrical interact with intact brain is not well understood. We performed vivo extracellular intracellular recordings from neocortex hippocampus anesthetized rats behaving rats. Electric were generated by sinusoid patterns at slow frequency (0.8, 1.25 or 1.7 Hz) via electrodes placed on surface skull dura. Transcranial stimulation...
Rapid eye movement (REM) sleep has been considered a paradoxical state because, despite the high behavioral threshold to arousing perturbations, gross physiological patterns in forebrain resemble those of waking states. To understand how intrahippocampal networks interact during REM sleep, we used 96 site silicon probes record from different hippocampal subregions and compared activity exploration sleep. Dentate/CA3 theta gamma synchrony was significantly higher with active waking. In...
Although anatomical, lesion, and imaging studies of the hippocampus indicate qualitatively different information processing along its septo-temporal axis, physiological mechanisms supporting such distinction are missing. We found fundamental differences between dorsal (dCA3) ventral-most parts (vCA3) in both environmental representation temporal dynamics. Discrete place fields dCA3 neurons evenly covered all testing environments. In contrast, vCA3 (1) rarely showed continuous two-dimensional...
During development, formation of topographic maps in sensory cortex requires precise temporal binding thalamocortical networks. However, the physiological substrate for such synchronization is unknown. We report that early gamma oscillations (EGOs) enable spatiotemporal neonatal rat whisker system. Driven by a thalamic oscillator and initially independent cortical inhibition, EGOs synchronize neurons single barreloid corresponding barrel support plasticity at developing synapses. propose...
Network dynamics have been proposed as a mechanistic substrate for the information transfer across cortical and hippocampal circuits. However, little is known about mechanisms that synchronize coordinate these processes widespread brain regions during offline states. Here we address hypothesis breathing acts an oscillatory pacemaker, persistently coupling distributed circuit dynamics. Using large-scale recordings from number of subcortical in behaving mice, uncover presence intracerebral...
The phase of spikes hippocampal pyramidal cells relative to the local field theta oscillation shifts forward ("phase precession") over a full cycle as animal crosses cell's receptive ("place field"). linear relationship between and travel distance within place is independent animal's running speed. This invariance phase-distance likely be important for coordinated activity space coding, yet mechanism responsible it not known. Here we show that at faster speeds are active fewer cycles but...
A thorough knowledge of the intrinsic circuit properties entorhinal cortex (EC) and temporal dynamics these circuits support is essential for understanding how information exchanged between hippocampus neocortex. Using intracellular extracellular recordings in anesthetized rat anatomical reconstruction single cells, we found that EC5 EC2 principal neurons form large axonal networks mainly within their layers, interconnected by more vertically organized axon trees EC3 pyramidal cells....
Two thin-film microelectrode arrays with integrated circuitry have been developed for extracellular neural recording in behaving animals. An eight-site probe simultaneous and stimulation has designed that includes on-chip amplifiers can be individually bypassed, allowing direct access to the iridium sites electrical stimulation. The on-probe a gain of 38.9 dB, an upper-cutoff frequency 9.9 kHz, input-referred noise 9.2 /spl mu/V /sub rms/ from 100 Hz 10 kHz. low-frequency cutoff amplifier is...
Abstract Graphene active sensors have demonstrated promising capabilities for the detection of electrophysiological signals in brain. Their functional properties, together with their flexibility as well expected stability and biocompatibility raised them a building block large-scale sensing neural interfaces. However, order to provide reliable tools neuroscience biomedical engineering applications, maturity this technology must be thoroughly studied. Here, we evaluate performance 64-channel...
Abstract Implantable active dense CMOS neural probes unlock the possibility of spatiotemporally resolving activity hundreds single neurons in multiple brain circuits to investigate dynamics. Mapping dynamics with anatomical structures spanning several millimeters, however, remains challenging. Here, a probe advancing lateral sampling for mapping intracortical (both LFPs and spikes) awake, behaving mice from an area >4 mm 2 is demonstrated. By taking advantage SiNAPS technology modularity,...
Sensor arrays used to detect electrophysiological signals from the brain are paramount in neuroscience. However, number of sensors that can be interfaced with macroscopic data acquisition systems currently limits their bandwidth. This bottleneck originates fact that, typically, addressed individually, requiring a connection for each them. Herein, we present concept frequency-division multiplexing (FDM) neural by graphene sensors. We demonstrate high performance transistors as mixers perform...
Using silicon-based recording electrodes, we recorded neuronal activity of the dorsal hippocampus and dorsomedial entorhinal cortex from behaving rats. The neurons were classified as principal interneurons based on monosynaptic interactions wave-shapes. hippocampal interactions, wave-shapes burstiness. data set contains recordings 7,736 (6,100 neurons, 1,132 interneurons, 504 cells that did not clearly fit into either category) obtained during 442 sessions 11 rats (a total 204.5 hours) while...
Natural vision requires circuit mechanisms which process complex spatiotemporal stimulus features in parallel. In the mammalian forebrain, one signature of activation is fast oscillatory dynamics, reflected local field potential (LFP). Using data from Allen Neuropixels Visual Coding project, we show that visual naturalistic stimuli induce mouse primary cortex (V1) retinotopically specific oscillations various frequency bands and V1 layers. Specifically, layer 4 (L4) narrowband gamma was...
The coordinated activity between remote brain regions underlies cognition and memory function. Although neuronal oscillations have been proposed as a mechanistic substrate for the coordination of information transfer consolidation during sleep, little is known about mechanisms that support widespread synchronization relationship dynamics with other bodily rhythms, such breathing. Here we address this question using large-scale recordings from number structures, including medial prefrontal...