A5023785597- Neuroscience and Neural Engineering
- Analytical Chemistry and Sensors
- 3D Printing in Biomedical Research
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Electrical and Bioimpedance Tomography
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Sensor and Energy Harvesting Materials
- Biosensors and Analytical Detection
- Advanced Chemical Sensor Technologies
- Microfluidic and Bio-sensing Technologies
- Graphene research and applications
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Carbon Nanotubes in Composites
- Photoreceptor and optogenetics research
- Body Composition Measurement Techniques
- Cardiac Ischemia and Reperfusion
- Gas Sensing Nanomaterials and Sensors
Universitat Autònoma de Barcelona
2014-2024
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2015-2024
Institut de Microelectrònica de Barcelona
2015-2024
Instituto de Salud Carlos III
2023-2024
STMicroelectronics (Czechia)
2023
Centro Nacional de Microelectrónica
2004-2022
Linköping University
2021
Centro de Investigación Biomédica en Red
2021
Consejo Superior de Investigaciones Científicas
1995-2018
Bioengineering Center
2017
Integrated inkjet-printed sensors in a liver-on-a-chip allow online oxygen monitoring, showing differential hepatocyte respiratory behaviour and an gradient.
While novel influential concepts in neuroscience bring the focus to local activities generated within a few tens of cubic micrometers brain, we are still devoid appropriate tools record and manipulate pharmacologically neuronal activity at this fine scale. Here designed, fabricated encapsulated microprobes for simultaneous depth recording drug delivery using exclusively polymer SU-8 as structural material. A tetrode- linear-like electrode patterning was combined first time with single double...
Abstract Brain–computer interfaces and neural prostheses based on the detection of electrocorticography (ECoG) signals are rapidly growing fields research. Several technologies currently competing to be first reach market; however, none them fulfill yet all requirements ideal interface with neurons. Thanks its biocompatibility, low dimensionality, mechanical flexibility, electronic properties, graphene is one most promising material candidates for interfacing. After discussing operation...
Abstract Conventional gut-on-chip (GOC) models typically represent the epithelial layer of gut tissue, neglecting other important components such as stromal compartment and extracellular matrix (ECM) that play crucial roles in maintaining intestinal barrier integrity function. These often employ hard, flat porous membranes for cell culture, thus failing to recapitulate soft environment complex 3D architecture mucosa. Alternatively, hydrogels have been recently introduced GOCs ECM analogs...
Establishing a reliable communication interface between the brain and electronic devices is of paramount importance for exploiting full potential neural prostheses. Current microelectrode technologies recording electrical activity, however, evidence important shortcomings, e.g. challenging high density integration. Solution-gated field-effect transistors (SGFETs), on other hand, could overcome these shortcomings if suitable transistor material were available. Graphene particularly attractive...
Abstract Measuring the spatiotemporal complexity of cortical responses to direct perturbations provides a reliable index brain's capacity for consciousness in humans under both physiological and pathological conditions. Upon loss consciousness, complex pattern causal interactions observed during wakefulness collapses into stereotypical slow wave, suggesting that bistability may play role. Bistability is mainly expressed form oscillations, default activity emerges from networks conditions...
This work presents a new microfluidic chip to facilitate multicellular interactions and cell barrier function monitoring in real time.
Transepithelial electrical resistance (TEER) measurements are regularly used in vitro models to quantitatively evaluate the cell barrier function.Although it would be expected that TEER values obtained with same type and experimental setup were comparable, reported literature show a large dispersion for unclear reasons.This work highlights possible error widely formula calculate TEER, which may erroneously assumed entire culture area contributes equally measurement.In this study, we have...
Self-powered sensors are analytical devices able to generate their own energy, either from the sample itself or surroundings. The conventional approaches rely heavily on silicon-based electronics, which results in increased complexity and cost, prevents broader use of these smart systems. Here we show that electrochromic materials can overcome existing limitations by simplifying device construction avoiding need for electronics entirely. Electrochromic displays be built into compact...
With a growing demand for the availability of inexpensive, simple, and rapid prototyped devices, prospect miniaturization reference electrodes using printing techniques becomes promising. A stable reusable full-inkjet-printed solid-state electrode (IPRE) was developed. The fully produced by consecutive inkjet several layers. Ag ink printed chlorinated NaClO printing, forming Ag/AgCl pseudoreference electrode. Then surface protection Cl–-saturated polyvinyl butyral membrane finally gave that...
Sensor arrays used to detect electrophysiological signals from the brain are paramount in neuroscience. However, number of sensors that can be interfaced with macroscopic data acquisition systems currently limits their bandwidth. This bottleneck originates fact that, typically, addressed individually, requiring a connection for each them. Herein, we present concept frequency-division multiplexing (FDM) neural by graphene sensors. We demonstrate high performance transistors as mixers perform...
Organs-on-a-chip (OoC) are cell culture platforms that replicate key functional units of tissues in vitro. Barrier integrity and permeability evaluation utmost importance when studying barrier-forming tissues. Impedance spectroscopy is a powerful tool widely used to monitor barrier real-time. However, data comparison across devices misleading due the generation non-homogenous field tissue barrier, making impedance normalization very challenging. In this work, we address issue by integrating...
Portal hypertension (PH) is a frequent and severe clinical syndrome associated with chronic liver disease. Considering the mechanobiological effects of hydrostatic pressure shear stress on endothelial cells, we hypothesised that PH might influence phenotype sinusoidal cells (LSECs) during disease progression. The aim this study was to investigate increased hydrodynamic LSECs identify endothelial-derived biomarkers PH.Primary were cultured under normal or within pathophysiological range (1...
This paper presents the design, fabrication, packaging and first test results of SU-8-based microneedles for neural applications. By use photolithography, sputtering bonding techniques, polymer needles with integrated microchannels electrodes have been successfully fabricated. The photolithography patterning fluidic channel in needle allows design multiple outlet ports at tip, minimizing possibility being blocked by tissue. Furthermore, flexibility reduces risk fracture tissue damage once is...