A5029689594- Nanowire Synthesis and Applications
- Neuroscience and Neural Engineering
- Mass Spectrometry Techniques and Applications
- Surface Modification and Superhydrophobicity
- Silicon Nanostructures and Photoluminescence
- Advanced Memory and Neural Computing
- Advanced Proteomics Techniques and Applications
- Electrowetting and Microfluidic Technologies
- ZnO doping and properties
- Molecular Junctions and Nanostructures
- Conducting polymers and applications
- Lipid Membrane Structure and Behavior
- Microfluidic and Capillary Electrophoresis Applications
- Force Microscopy Techniques and Applications
- Analytical Chemistry and Chromatography
- Nanofabrication and Lithography Techniques
- Copper-based nanomaterials and applications
- Thin-Film Transistor Technologies
- Nerve injury and regeneration
- Diatoms and Algae Research
- Retinal Development and Disorders
- Advanced Chemical Sensor Technologies
- EEG and Brain-Computer Interfaces
- Anodic Oxide Films and Nanostructures
- Gas Sensing Nanomaterials and Sensors
Université Grenoble Alpes
2015-2024
Inserm
2010-2017
Clinatec
2015-2016
Centre Hospitalier Universitaire de Grenoble
2016
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2015-2016
Université Joseph Fourier
2016
Lund University
2012-2015
CEA Grenoble
2015
CEA LETI
2015
Laboratoire de physique des Solides
2015
Abstract Brain–computer interfaces and neural prostheses based on the detection of electrocorticography (ECoG) signals are rapidly growing fields research. Several technologies currently competing to be first reach market; however, none them fulfill yet all requirements ideal interface with neurons. Thanks its biocompatibility, low dimensionality, mechanical flexibility, electronic properties, graphene is one most promising material candidates for interfacing. After discussing operation...
The electrode material is a key element in the design of long-term neural implants and neuroprostheses. To date, ideal offering high longevity, biocompatibility, low-noise recording stimulation capabilities remains to be found. We show that 3D-nanostructured boron doped diamond (BDD), an innovative consisting chemically stable with aspect ratio structure obtained by encapsulation carbon nanotube template within two BDD nanolayers, allows cell attachment, survival neurite extension. Further,...
This paper reports on the use of silicon nanowires (SiNWs), easily prepared in a single step by chemical etching crystalline HF/AgNO3 aqueous solution, as highly sensitive substrate for laser desorption/ionization mass spectrometry (LDI-MS) analysis. The SiNWs' diameter and length depend etchant concentration dissolution time. Optimized LDI consists with an average range 20−100 nm 2.5 μm length. optimized surface morphology coupled to controlled chemistry allowed significant LDI-MS...
Interfacing nanowires and living cells is highly interesting in various fields including biomedical implants, biosensors or drug delivery. Vertically aligned silicon nanowire (SiNW) arrays prepared by the stain etching technique were investigated this study. Chemical modification with octadecyltrichlorosilane (OTS) led to formation of superhydrophobic SiNW surface a contact angle around 160°. A micropatterned superhydrophilic/superhydrophobic was fabricated using standard optical lithography...
We have established long-term cultures of postnatal retinal cells on arrays gallium phosphide nanowires different geometries. Rod and cone photoreceptors, ganglion bipolar survived the substrates for at least 18 days in vitro. Glial were also observed, but these did not overgrow neuronal population. On nanowires, neurons extended numerous long branched neurites that expressed synaptic vesicle marker synaptophysin. The longest (4 μm long) allowed a greater attachment neurite elongation our...
We present for the first time an electrowetting on dielectric (EWOD) microfluidic system coupled to a surface-assisted laser desorption-ionization (SALDI) silicon nanowire-based interface mass spectrometry (MS) analysis of small biomolecules. Here, transfer analytes has been achieved specific locations SALDI followed by their subsequent without use organic matrix. To achieve this purpose, device comprising digital and patterned superhydrophobic/superhydrophilic nanowire was developed. The...
Neural cultures are very useful in neuroscience, providing simpler and better controlled systems than the vivo situation. tissue contains two main cell types, neurons glia, interactions between these essential for appropriate neuronal development. In neural cultures, glial cells tend to overgrow neurons, limiting access interrogation. There is therefore a pressing need improved that enable good separation when coculturing simultaneously, allowing one address unequivocally. Here, we used...
We report on the use of patterned superhydrophobic silicon nanowire surfaces for efficient, selective transfer biological molecules and nanoparticles. Superhydrophilic patterns are prepared using standard optical lithography. The resulting water-repellent surface allows material physisorption to superhydrophilic islands upon exposure an aqueous solution containing peptides, proteins, or
The article reports on the selective adhesion of Bacillus cereus spores patterned and heterogeneously wetted superhydrophobic silicon nanowires surfaces. Superhydrophilic patterns nanowire (SiNW) surfaces were prepared by a standard optical lithography technique. Exposure surface to suspension B. in water led their specific adsorption areas. Comparable results obtained hydrophobic/hydrophilic flat (Si) even though higher concentration was observed hydrophobic areas, as compared regions SiNW...
The paper reports on the optical properties of ZnO nanostructures elaborated a zinc foil substrate by simple chemical approach. doping type and density were evaluated using electrochemical impedance spectroscopy. XRD diffraction patterns Raman spectroscopy used to study structural evolution upon thermal annealing at 300 °C for 1 h in air. Their properties, probed low temperature photoluminescence room cathodoluminescence (CL), are correlated their electronic properties. luminescence nanorods...
The paper reports on the use of a titanium oxide (TiO2) nanotube layer as sensitive substrate for surface-assisted laser desorption–ionization mass spectrometry (SALDI-MS) peptides and small molecules. layers were prepared by electrochemical anodization foil. optimized TiO2 nanotubes morphology coupled to controlled surface chemistry allowed (D/I) peptide mixture (Mix1) with detection limit 10 femtomoles neurotensin peptide. performance D/I molecules was also tested sutent, tyrosine kinase...
Sensing and manipulating living cells using vertical nanowire devices requires a complete understanding of cell behavior on these substrates. Changes in function phenotype are often triggered by events taking place at the plasma membrane, properties which influenced local curvature. The topography can therefore be expected to greatly affect emphasizing importance studying membranes arrays. Here, we used supported phospholipid bilayers as model for biomembranes. We demonstrate formation fluid...
Limitations of silicon nanowire arrays produced using chemical etching for drug delivery.
Peptide microarrays are useful tools for the characterization of humoral responses against peptide antigens. The study post-translational modifications requires printing appropriately modified peptides, whose synthesis can be time-consuming and expensive. We describe here a method named "chips from chips", which allows probing presence antibodies directed toward antigens starting unmodified microarrays. chip concept is based on modification microspots by simple chemical reactions. (parent...
Introduction: Many invasive and noninvasive neurotechnologies are being developed to help treat neurological pathologies disorders. Making a brain implant safe, stable, efficient in the long run is one of requirements conform with neuroethics overcome limitations for numerous promising neural treatments. A main limitation low biocompatibility, characterized by damage implants create tissue their adhesion it. This partly linked friction over time due mechanical mismatch between soft more...
We used two methods, namely stamping and printing, to transfer arrays of epitaxial gallium phosphide (GaP) nanowires from their growth substrate a soft, biodegradable layer polycaprolactone (PCL). Using the method resulted in very inhomogeneous surface topography with wide distribution transferred nanowire lengths, whereas using printing an homogeneous over several mm2. PC12 cells were cultured on hybrid nanowire-PCL substrates realized exhibited increased attachment these substrates,...
Nanostructures grown or deposited on reflective substrates enable the visualization of fluorophores and assessment fluidity self-assembled bilayers surfaces.